Lipid Peroxidation and Antioxidant Defence System in Patients with Active or Inactive Behçet's Disease

Abstract

To evaluate plasma lipid peroxidation and enzymatic and non-enzymatic antioxidant systems in patients with Behçet's disease, plasma malondialdehyde levels and total antioxidant status, erythrocyte superoxide dismutase and whole blood glutathione peroxidase activities were studied in 15 patients with active disease and in 30 with inactive disease, and compared with 20 age-matched healthy control subjects. Plasma malondialdehyde levels were significantly higher in patients with active Behçet's disease than in patients with inactive disease, who had significantly higher levels than control subjects. The plasma total antioxidant status of both groups of patients was significantly lower than that of controls. Furthermore, whole blood glutathione peroxidase activity was significantly lower in patients with active versus inactive Behçet's disease. There were no significant differences in erythrocyte superoxide dismutase levels between the groups. In conclusion, there is an increase in oxidative stress in Behçet's disease. Despite this stress, the antioxidant system is deficient and inadequate, especially in patients who are in an active phase of the disease.

Decreased Total Antioxidant Response and Increased Oxidative Stress in Behcet's Disease

“…In BD, TAS levels have been reported to decrease (Orem et al 2002;Sandikci et al 2003;Buldanlioglu et al 2005), except for one study (Bekpinar et al 2005). Similarly, in the present study, TAR level was lower in the BD group, and it was correlated with the activity of CP and the level of SH.…”

Could Mean Platelet Volume Be Used as A Marker for Oral Aphthae and Activity of Behçet’s Disease?

“…Our findings confirm that inflammation plays a role in the pathology of Behçet's disease and are consistent with the CRP results of Sandıkcı et al (5). The values of fibrinogen levels and sedimentation rate, which are other markers of inflammation, were revealed to be higher in all Behçet's disease patients than in the control group patients.…”

Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

“…We detec ted that the LDL-C le vels of inac ti ve, ac ti ve and to tal pa ti ent gro ups we re sig ni fi cantly hig her in com pa ri son to those of the con trol gro up. Our findings on li pid le vels are com pa tib le with that of San dik ci, 5 Mi ta mu ra, 35 Orem 24,36,37 and Cham bers 38 et al In BD, as a re sult of an in cre a se in TG and LDL-C le vels, li pids and li pop ro te ins ex po sed to oxi da ti ve stress de ve lop li pid pe ro xi da ti on pro ducts. The re fo re, this may be the res pon sib le fac tor of endot he li al dysfunc ti on in BD.…”

“…5,[24][25][26] Be ing a mul ti func ti o nal pro inf lam ma tory cyto ki ne re gu la ting im mu ne res pon se, IL-6 is pro duced by mo nocy tes, epit he li al cells and fib rob lasts and it ca u ses poly clo nal B cell ac ti va ti on, hypergam mag lo bu li ne mi a and T cell ac ti va ted au to an tibody pro duc ti on. 27,28 It was po in ted out that the sec re ti on of acu te pha se re ac tants en han ces the pro li fe ra ti on and dif fe ran ti a ti on of the cells.…”

“…Ge ne tic factors, infec ti on, im mu nog lo bu lins, im mu ne-comp le xes, an ti bo di es and oxi da ti ve stress ha ve be en al le ged as the ca u ses of BD. [3][4][5] Eve rek li og lu et al and Bul danli og lu et al, po in ted out that nit ric oxi de le vels were in cre a sed in BD pa ti ents and this increase was as so ci a ted to ac ti va ti on of the di se a se. 6,7 Cyto ki nes are low-mo le cu lar-we ight bi o ac tive poly pep ti des func ti o ning in in ter cel lu lar commu ni ca ti ons.…”