Lipid Peroxidation and Mitochondrial Superoxide Dismutase-2 Gene in Adolescents with Essential Hypertension

Abstract

The study of LPO processes in adolescents of different races with essential hypertension revealed that Mongoloids exhibit oxidative stress by altering the level of the formation of diene conjugates, the primary LPO products. Caucasians increased the levels of both primary and end products of LPO, diene conjugates, and malondialdehyde. The revealed differences can be genetically determined because ethnic differences in the frequency of SOD2 gene Ala16Val polymorphism and its contribution to the biochemical phenotype were reported. The risk factors are Ala allele associated with increased MDA level for adolescent Caucasians and Val allele linked with decreased level of total antioxidant activity for adolescent Mongoloids.

Maternal protein restriction induced‐hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata

“…Thus, we suggest that dysfunction between ROS and antioxidant capacity may be more pronounced in the ventral medulla, which contributes, in part, to the development of sympathetic overactivation and hypertension observed in rats exposed to protein restriction during pregnancy and lactation. Interestingly, clinical studies have shown that lipid peroxidation (MDA levels) is augmented in blood of patients with essential hypertension, and at the same time, SOD and CAT activities are reduced in these patients …”

“…Interestingly, clinical studies have shown that lipid peroxidation (MDA levels) is augmented in blood of patients with essential hypertension, and at the same time, SOD and CAT activities are reduced in these patients. 40,41 Previous studies have suggested that oxidative stress in the dorsal medulla (or specifically in nucleus tractus solitarii), it may be associated with hypertension model in which there depression of the baroreflex. 14 Interestingly a recent study demonstrated that the hypertension in rat offspring subjected to perinatal protein malnutrition is not related to the baroreflex dysfunction.…”

Free radical oxidation: a pathophysiologist’s view

“…У под-ростков с лабильной артериальной гипертензией окислительный стресс формируется за счет ин-тенсификации процессов ПОЛ на стадии образо-вания кетодиенов (КД) и сопряженных триенов (СТ), а в группе со стабильной артериальной ги-пертензией -на стадии образования первичных продуктов -диеновых конъюгатов (ДК) и конеч-ных продуктов ПОЛ [68]. Значимыми явились также данные об ýтногенетической детерминиро-ванности окислительного стресса при формиро-вании ýссенциальной артериальной гипертензии у детей (в группе подростков-бурят коýффициент окислительного стресса оказался равным 2,60, что было ниже, чем у русских -5,31) [69].…”

Activity of Lipid Peroxidation Processes in Pregnant Women With Chronic Viral Hepatitis

“…Дисбаланс этой системы сопровождает или является причиной более двухсот заболеваний у человека [7,13].…”