Lipid peroxidation end products in patients with acute coronary syndrome

et al. 2018

IJBM

The aim of this research was to study the blood levels of protein oxidation products and superoxide dismutase (SOD) activity and their relationship with lipid profile parameters in patients with coronary heart disease (CHD). In CHD patients, against a background of low SOD activity, the protein carbonyl content (PCC) level was significantly higher than in the control group. In addition, significant correlations were found between the indices of PCC, SOD activity, and lipid profile parameters.

Section: Resultsmentioning

confidence: 99%

Markers of Oxidative Stress in Patients with Coronary Heart Disease

Kotova¹,

et al. 2018

IJBM

“…(3)(4)(5)(6) In CHD, a decrease in intracellular protection against reactive oxygen species, primarily due to a decrease in the level of SOD-the key enzyme of the antioxidant system-has been demonstrated by a number of researchers. (7) The imbalance between pro-oxidants and antioxidants leads to oxidative damage of proteins-an early indicator of the cell damage, (8,9) including the endothelium.In contrast to their inherent harms, ROS also function as signaling molecules, inducing stress tolerance mechanisms. OS can be responsible for the increased expression of HSPs.…”

Section: Introductionmentioning

confidence: 99%

Predictors of Coronary Atherosclerosis: HSP70, Markers of Oxidative Stress and Endothelial Dysfunction

Kotova¹,

et al. 2019

IJBM

The aim of this study was to evaluate the role of HSP70, and markers of oxidative stress and endothelial dysfunction, as determinants of the severity of coronary atherosclerosis. The study revealed significant differences between patient groups with and without coronary atherosclerosis in terms of HSP70, superoxide dismutase, total homocysteine (tHcy) and markers of oxidative modification of proteins. Significant correlations between Gensini score, lipid profile parameters and studied markers were determined. The results of multiple linear regression analysis allow us to consider the levels of HSP70, tHcy, LDL-C and ketone derivative of 2.4-dinitrophenylhydrazine as factors associated with the risk of coronary atherosclerosis.

“…(5) The imbalance between pro-oxidants and antioxidants leads to oxidative damage of proteins-an early indicator of the cell damage. (6,7) Oxidants induce the posttranslational modification of proteins. (8) Peroxide treatment of rat cardiac myocytes rapidly induces phosphorylation of Hsp27, which increases the activity of Hsp27.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Indices of Oxidative Stress, Endothelial Dysfunction and Chaperone Activity and the Severity of Coronary Atherosclerosis

Kotova¹,

et al. 2018

IJBM

The aim of this research was to study the relationship between the indices of oxidative stress, endothelial dysfunction and chaperone activity of proteins with the severity of coronary atherosclerosis. In patients with coronary heart disease, we found gender-related differences in the severity of coronary atherosclerosis. Significant differences in the indices of oxidative stress, endothelial dysfunction and chaperone activity were revealed depending on the severity of coronary atherosclerosis and the type of atherosclerotic lesion. The determination of studied parameters can serve as a good indicator of the severity of coronary atherosclerosis.