Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model

Antunes, Fernando; Salvador, Armindo; Marinho, H. Susana; Alves, Ricardo; Pinto, Ruy E.

doi:10.1016/s0891-5849(96)00185-2

Cited by 131 publications

(92 citation statements)

References 114 publications

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“…Vitamin E is another example, as it is composed of tocopherol. Tocopherol induces several chain breaking reactions, including the reduction of peroxyl and alkoxyl radicals, reactions with carbon centred radicals and the addition of a tocopheroxyl itself to a peroxyl radical (Antunes et al 1996).…”

Section: Inhibitors For Oxidation Of Oilsmentioning

confidence: 99%

Low temperature oxidation of linseed oil: a review

et al. 2012

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This review analyses and summarises the previous investigations on the oxidation of linseed oil and the self-heating of cotton and other materials impregnated with the oil. It discusses the composition and chemical structure of linseed oil, including its drying properties. The review describes several experimental methods used to test the propensity of the oil to induce spontaneous heating and ignition of lignocellulosic materials soaked with the oil. It covers the thermal ignition of the lignocellulosic substrates impregnated with the oil and it critically evaluates the analytical methods applied to investigate the oxidation reactions of linseed oil. Initiation of radical chains by singlet oxygen ( 1 Δ g ), and their propagation underpin the mechanism of oxidation of linseed oil, leading to the self-heating and formation of volatile organic species and higher molecular weight compounds. The review also discusses the role of metal complexes of cobalt, iron and manganese in catalysing the oxidative drying of linseed oil, summarising some kinetic parameters such as the rate constants of the peroxidation reactions. With respect to fire safety, the classical theory of self-ignition does not account for radical and catalytic reactions and appears to offer limited insights into the autoignition of lignocellulosic materials soaked with linseed oil. New theoretical and numerical treatments of oxidation of such materials need to be developed. The self-ignition induced by linseed oil is predicated on the presence of both a metal catalyst and a lignocellulosic substrate, and the absence of any prior thermal treatment of the oil, which destroys both peroxy radicals and singlet O 2 sensitisers. An overview of peroxyl chemistry included in the article will be useful to those working in areas of fire science, paint drying, indoor air quality, biofuels and lipid oxidation.

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Section: Inhibitors For Oxidation Of Oilsmentioning

confidence: 99%

Low temperature oxidation of linseed oil: a review

et al. 2012

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“…Mitochondrial DNA is particularly sensitive to ROS because of the lack of histone protective system as is the case of nuclear DNA. These alterations result in mitochondrial dysfunction with (i) decreased ATP production (ROS injury on ETC) [16], (ii) membrane permeabilization (ROS injury on lipid membrane) [17], (iii) mtDNA rearrangements [18] leading to various mitochondrial diseases [19].…”

Section: How When and Why Are Ros Produced In Mitochondria?mentioning

confidence: 99%

Determination of mitochondrial reactive oxygen species: methodological aspects

Batandier

Fontaine

Kériel

et al. 2002

J Cellular Molecular Medi

139

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The generation of Reactive Oxygen Species (ROS) as by-products in mitochondria Electron Transport Chain (ETC) has long been admitted as the cost of aerobic energy metabolism with oxidative damages as consequence. The purpose of this methodological review is to present some of the most widespread methods of ROS generation and to underline the limitations as well as some problems, identified with some experiments as examples, in the interpretation of such results. There is now no doubt that besides their pejorative role, ROS are involved in a variety of cellular processes for the continuous adaptation of the cell to its environment. Because ROS metabolism is a complex area (low production, instability of species, efficient antioxidant defense system, several places of production…) bias, variances and limitations in ROS measurements must be recognized in order to avoid artefactual conclusions, and especially to improve our understanding of physiological and pathophysiological mechanisms of such phenomenon.

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“…From these values, taking into account the pKa of O~ and assuming that the contribution of O~ itself is negligible, we can roughly estimate that the partition coefficient of HO 2" is between 0.33 and 1. Other authors have estimated the partition coefficient for HO 2" at 1 (154). A partition coefficient of 1 would indicate that HO 2" is equally soluble in the membrane and the aqueous phase.…”

Section: The Rate Of 02; Production Controls Lifespan Independently Omentioning

confidence: 99%

“…HO 2" can initiate lipid peroxidation, reacting with a variety of polyunsaturated fatty acids (PU FAs) with rate constants of around k=103 M -~ s -1 (156)(157)(158). Using computational and mathematical models, it has been argued that HO 2" is the main cause of lipid peroxidation in the inner mitochondrial membrane in vivo (154). Although the rate constant for the reaction of HO 2" with PUFAs might not seem very large, the concentration of PUFAs is relatively high, so the reaction can be quite significant.…”

Section: The Rate Of 02; Production Controls Lifespan Independently Omentioning

confidence: 99%

The nature and mechanism of superoxide production by the electron transport chain: Its relevance to aging

Muller

2000

AGE

122

123

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Most biogerontologists agree that oxygen (and nitrogen) free radicals play a major role in the process of aging. The evidence strongly suggests that the electron transport chain, located in the inner mitochondrial membrane, is the major source of reactive oxygen species in animal cells. It has been reported that there exists an inverse correlation between the rate of superoxide/hydrogen peroxide production by mitochondria and the maximum longevity of mammalian species. However, no correlation or most frequently an inverse correlation exists between the amount of antioxidant enzymes and maximum longevity. Although overexpression of the antioxidant enzymes SOD1 and CAT (as well as SOD1 alone) have been successful at extending maximum lifespan in Drosophila, this has not been the case in mice. Several labs have overexpressed SOD1 and failed to see a positive effect on longevity. An explanation for this failure is that there is some level of superoxide damage that is not preventable by SOD, such as that initiated by the hydroperoxyl radical inside the lipid bilayer, and that accumulation of this damage is responsible for aging. I therefore suggest an alternative approach to testing the free radical theory of aging in mammals. Instead of trying to increase the amount of antioxidant enzymes, I suggest using molecular biology/ transgenics to decrease the rate of superoxide production, which in the context of the free radical theory of aging would be expected to increase longevity. This paper aims to summarize what is known about the nature and mechanisms of superoxide production and what genes are involved in controlling the rate of superoxide production.

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Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model

Cited by 131 publications

References 114 publications

Low temperature oxidation of linseed oil: a review

Low temperature oxidation of linseed oil: a review

Determination of mitochondrial reactive oxygen species: methodological aspects

The nature and mechanism of superoxide production by the electron transport chain: Its relevance to aging

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