Lipid peroxidation mediated the association of urinary 1-bromopropane metabolites with plasma glucose and the risk of diabetes: A cross-sectional study of urban adults in China

Yang, Shijie; Zhou, Min; Wang, Bin; Ge, Minghua; Wang, Xing; Yuan, Jing; Chen, Weihong

doi:10.1016/j.jhazmat.2019.121889

Cited by 10 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Understanding causal mechanisms in observational studies is challenging and even more difficult given the complexity and long latency period of cancer. Although mediation analysis has been applied in social and epidemiological research for decades to understand causal pathways and biological mechanisms, surprisingly, its use in environmental and exposure epidemiology has been relatively infrequent. ,− Although the results of our mediation analyses were not significant at a 95% CI cutoff point and should be interpreted with caution, they suggested that the potential long-term carcinogenic effect of β-HCH exposure might be partially mediated by alterations in local redox balance. This might also be the case for other highly correlated POPs, such as HCB and PCBs, although confidence intervals were larger and more imprecise.…”

Section: Discussionmentioning

confidence: 75%

Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

Mustieles

Pérez-Carrascosa

León

et al. 2021

Environ. Sci. Technol.

View full text Add to dashboard Cite

We aimed to assess the relationships among the adipose tissue’s (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003–2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT’s oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.

show abstract

Section: Discussionmentioning

confidence: 75%

Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

Mustieles

Pérez-Carrascosa

León

et al. 2021

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…1-bromopropane is a solvent in adhesive, degreasing, cleaning, and automobile care products and can also be used as an intermediate in pharmaceuticals and insecticides production; it enters the human body through inhalation and dermal contact, and to a lesser extent, through digestion [ 27 , 28 ]. 1-Bromopropane causes oxidative stress and oxidative damage via glutathione depletion through conjugation as well as via downregulation of glutathione peroxidase expression [ 27 , 29 ]. Yet, we found the association between urinary 1-bromopropane metabolite and FEV 1 % predicted only in participants with cotinine levels indicative of SHS exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Yet, we found the association between urinary 1-bromopropane metabolite and FEV 1 % predicted only in participants with cotinine levels indicative of SHS exposure. Prior epidemiological studies conducted on occupational settings with high 1-bromopropane exposure levels reported associations with adverse respiratory outcomes [ 27 ]. In one of the rare studies on 1-bromopropane and respiratory outcomes conducted in general populations, urinary metabolite levels of this chemical were associated with reduced FEV 1 and FVC volumes among 3259 Chinese adults [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Urinary Volatile Organic Compound Metabolites Are Associated with Reduced Lung Function in U.S. Children and Adolescents

Mendy,

Burcham,

Merianos

et al. 2024

Toxics

View full text Add to dashboard Cite

(1) Background: Volatile organic compounds (VOCs) are indoor pollutants absorbed by inhalation. The association of several VOCs with lung function in children and adolescents is unknown. (2) Methods: We analyzed 505 participants, 6–17-year-olds from the 2011–2012 National Health and Nutrition Examination Survey. Multiple linear regression models were fitted to estimate the associations of VOC metabolites with spirometry outcomes adjusting for covariates. (3) Results: Urinary metabolites of xylene, acrylamide, acrolein, 1,3-butadiene, cyanide, toluene, 1-bromopropane, acrylonitrile, propylene oxide, styrene, ethylbenzene, and crotonaldehyde were all detected in ≥64.5% of participants. Forced expiratory volume in 1 s (FEV1) % predicted was lower in participants with higher levels of metabolites of acrylamide (β: −7.95, 95% CI: −13.69, −2.21) and styrene (β: −6.33, 95% CI: −11.60, −1.07), whereas the FEV1 to forced vital capacity (FVC) ratio % was lower in children with higher propylene oxide metabolite levels (β: −2.05, 95% CI: −3.49, −0.61). FEV1 % predicted was lower with higher crotonaldehyde metabolite levels only in overweight/obese participants (β: −15.42, 95% CI: −26.76, −4.08) (Pinteraction < 0.001) and with higher 1-bromopropane metabolite levels only in those with serum cotinine > 1 ng/mL (β: −6.26, 95% CI: −9.69, −2.82) (Pinteraction < 0.001). (4) Conclusions: We found novel associations of metabolites for acrylamide, propylene oxide, styrene, 1-bromopropane and crotonaldehyde with lower lung function in children and adolescents.

show abstract

1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway

Wu,

Jin,

Liu

et al. 2025

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

Lipid peroxidation mediated the association of urinary 1-bromopropane metabolites with plasma glucose and the risk of diabetes: A cross-sectional study of urban adults in China

Cited by 10 publications

References 42 publications

Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

Urinary Volatile Organic Compound Metabolites Are Associated with Reduced Lung Function in U.S. Children and Adolescents

1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway

Contact Info

Product

Resources

About