Lipid peroxides in the serum of asphyxiated neonates

Ramy, Nermin; Sharany, W Al; Mohamed, Mohamed A.; Madani, Hanan; Saleh, Eman A.; Aly, Hany

doi:10.1038/jp.2016.97

Cited by 5 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rodent models have shown abundant formation of LPOs in the brain after HI, and the serum levels of malondialdehyde, which is an end-product of lipid peroxidation, increase in neonates after HI (El Bana et al, 2016). Serum LPO concentrations increase significantly in asphyxiated infants, and this correlates with the clinical grading of hypoxic–ischemic encephalopathy and mortality (Ramy et al, 2016). The level of LPO, as well as the severity of cell damage, can be reduced by the iron chelator DFO (Peeters-Scholte et al, 2003; Rathnasamy et al, 2011).…”

Section: Neonatal Brain Injurymentioning

confidence: 99%

The Potential Role of Ferroptosis in Neonatal Brain Injury

Shi

Wang

et al. 2019

Front. Neurosci.

View full text Add to dashboard Cite

Ferroptosis is an iron-dependent form of cell death that is characterized by early lipid peroxidation and different from other forms of regulated cell death in terms of its genetic components, specific morphological features, and biochemical mechanisms. Different initiation pathways of ferroptosis have been reported, including inhibition of system X c - , inactivation of glutathione-dependent peroxidase 4, and reduced glutathione levels, all of which ultimately promote the production of reactive oxygen species, particularly through enhanced lipid peroxidation. Although ferroptosis was first described in cancer cells, emerging evidence now links mechanisms of ferroptosis to many different diseases, including cerebral ischemia and brain hemorrhage. For example, neonatal brain injury is an important cause of developmental impairment and of permanent neurological deficits, and several types of cell death, including iron-dependent pathways, have been detected in the process of neonatal brain damage. Iron chelators and erythropoietin have both shown neuroprotective effects against neonatal brain injury. Here, we have summarized the potential relation between ferroptosis and neonatal brain injury, and according therapeutic intervention strategies.

show abstract

Section: Neonatal Brain Injurymentioning

confidence: 99%

The Potential Role of Ferroptosis in Neonatal Brain Injury

Shi

Wang

et al. 2019

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…They were relatively few, with just two orders, eight families, and ten species represented in six species of Dipera belonging to four families, four species of Coleoptera belonging to three families. In a similar study, ten arthropod species and 7 families were detected on the rabbit and rat carcasses in Egypt (35). This observation may be attributable to the small size of the corpse, which could be quickly devoured by the early invader arthropods, depriving later colonizer species of the opportunity to colonize resulting in faster decomposition and shorter postmortem period (36).…”

Section: Discussionmentioning

confidence: 87%

Identification of Forensically Important Insects on Atrazine-Intoxicated Rat Carcasses at Different Decomposition Stages Dur-Ing Summer Season

Saber,

Hassanen,

Anter

et al. 2021

SVR

View full text Add to dashboard Cite

This study was designed to assess the effect of atrazine, the most commonly used herbicide in Egypt, on the decay process of intoxicated rat carrions and their associated forensically important insects during the summer season. Six Sprague-Dawley rats were assigned into groups. Cervical dislocation was used for killing the 1st group, and served as the control, whereas atrazine intoxication was utilized to kill the 2nd group. Control carcasses decomposed quickly, taking only 19 days to reach the skeletal stage. Decay of atrazine-intoxicated carrions was delayed since they reached the skeletal stage in 30 days. In addition, a delay in the colonization of insect fauna for atrazine-intoxicated carcasses was observed. The predominant necrophagous arthropods involved in the decomposition process were the orders Diptera and Coleoptera. The insect family Calliphoridae was the first to colonize the corpses and persisted until the beginning of the advanced decay stage. The results revealed that atrazine affected the succession pattern of carrion-feeding insects. In the control group, Dipteran insects were the most dominant insects (57.14%), and then Coleopteran insects were the following ones (42.85%). While the atrazine-intoxicated group showed 42.85% for insects of order Diptera and 57.14% for Coleoptera. This work suggested that the atrazine intoxication affected the decomposition process of rat carrions and their related arthropod fauna during the summer season, which could aid in the future forensic investigations of suspected pesticide poisoning.

show abstract

“…Similarly, lipid peroxidation (LPO) concentrations measured by ELISA may correlate with severity of encephalopathy, Apgar score, and initial blood pH. Additionally, LPO concentrations were higher in infants with asphyxia who died compared to those who survived [88]. LPO elevation had 89% sensitivity, 96% specificity, 96% PPV, and 90% NPV for the diagnosis of neonatal hypoxic-ischemic encephalopathy [89].…”

Section: Mechanisms and Therapeutic Targeting Of Ferroptosis In Hibimentioning

confidence: 99%

Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury

Peeples

Genaro-Mattos

2022

IJMS

View full text Add to dashboard Cite

Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic brain injury (HIBI). This review summarizes the current literature regarding the different ferroptotic pathways, how they may be activated after neonatal HIBI, and which current or investigative interventions may attenuate ferroptotic cell death associated with neonatal HIBI.

show abstract

Lipid peroxides in the serum of asphyxiated neonates

Abstract: LPO was increased and correlated with severity of asphyxia as well as with mortality. Further studies are warranted to examine whether it is only a marker for outcome or a contributor in the pathogenesis of hypoxic-ischemic brain injury.

Cited by 5 publications

References 22 publications

The Potential Role of Ferroptosis in Neonatal Brain Injury

The Potential Role of Ferroptosis in Neonatal Brain Injury

Identification of Forensically Important Insects on Atrazine-Intoxicated Rat Carcasses at Different Decomposition Stages Dur-Ing Summer Season

Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury

Contact Info

Product

Resources

About