Lipid-Polymer Hybrid Nanocarriers as a Novel Drug Delivery Platform

Abstract

The main aim of my review to discuss the most prominent nanocarrier, “Lipid-Polymer Hybrid Nanoparticle” (LPHNPs) that overcomes the limitation of lipid and polymeric nanoparticles. That consists of polymeric core and lipid outer layer. The polymeric core encapsulates both hydrophilic and hydrophobic drugs and lipid shell provides a coat that gives a barrier to prevent drug leakage and easily penetrate into the skin. The LPHNPs has significant application in drug delivery, drug targeting, cancer treatment, brain drug delivery, multiple drug delivery, delivery of diagnostic imaging agent and Small interfering Ribonucleic acid (siRNA). This session is based on literature information in which LPHNPs were prepared by Two-step and Single-step method. Most of the researcher use the Single-step method by emulsification solvent evaporation and Nanoprecipitation method that are easy to prepare LPHNPs. The Polylactic Glycolic acid (PLGA), Poly € caprolactone, Chitosan, Alginate, Dextron, Sodium Alginate, etc used as polymeric core and Stearic Acid, Palmitic Acid, Cetyl Alcohol, Behenol Alcohol, etc used as lipid core. All results were analyzed by us according to the literature and authors’ expertise. The drug release depends on diffusion processes, followed by erosion, then swelling of the matrix. The lipid shell provides a biocompatible shield that acts as the phospholipid bilayer of skin and easily penetrates into the skin. That also capable to deliver the multidrug and diagnostic imaging agent for the treatment of cancer. The Lipid-Polymer Hybrid Nanoparticles are the most prominent nanocarrier for drug delivery. That is capable to deliver both Hydrophilic and Lipophilic drugs and show high bioavailability.

Focus on Niosomal–based Drug Delivery Systems for Nasal Route: Applications and Challenges

“…To optimize and improve nasal drug uptake, various drug delivery systems are under investigation. Lipidic-based nasal delivery systems like niosomes, liposomes, in-situ gel systems, cyclodextrins, microemulsions, and nanoemulsions [12][13][14], can be considered as one type of the most emerging drug delivery systems utilized in the nasal delivery route (fig. 2).…”

Skin Targeting of an Optimized Caffeine Nanostructured Lipid Carrier With Improved Efficiency Against Chemotherapy Induced Alopecia

“…Optimization of caffeine-loaded NLCs was achieved using 2 3 full factorial designs at two levels and three variables strategies (Design-ExpertV.10.0.5 software, State-Ease Inc., Minneapolis, USA). The drug concentration (1.5 and 3 % w/w), lipid type (O: G: stearic or (O: G: GMS) at a ratio of 15:15:70), and emulsifier type (Tween 80/transcutol HP and Cremophore EL/transcutol HP) were the independent variables.…”

“…Further investigation of the effects of several factors on the %EE of caffeine-loaded NLCs was carried out. The data was analyzed using 2 3 full factorial designs at two levels and three variables strategies.…”

“…These novel systems are different from the conventional ones in their structures (internal and external matrix). Different classes of nanocarriers such as solid lipid nanoparticles (SLNs), liposomes, transfersomes, NLCs, micro and nanoemulsion, niosomes, dendrimers, and invasomes were developed for topical applications [3]. They are formulated for the efficacious delivery of bioactive agents with unlike physical characters through the skin.…”

Formulation, Characterization and Optimization of Folic Acid-Tailored Daidzein Solid Lipid Nanoparticles for the Improved Cytotoxicity Against Colon Cancer Cells

“…Solid lipid nanoparticles (SLNs) will be developed to overcome these issues as they are biodegradable, offer low toxicity, low dosage requirement, overcome first-pass metabolism, enhance orally administered drug reaching into the systemic circulation, and exhibit sustained drug release at periodic intervals [8]. Active targeting of anticancer agents leverages specific interactions between receptors present abundantly on the surface of tumor cells and ligands attached to the polymer backbone [9]. This approach capitalises on the enhanced permeability and retention (EPR) effect and significantly improves the therapeutic index by facilitating receptor-mediated tumor-cell uptake [10,11].…”