Lipid Profile Abnormalities in Newly Diagnosed Primary Hypothyroidism in a Tertiary Care Centre of Western Nepal: A Descriptive Cross-sectional Study

Khatri, Prabin; Neupane, Aryan; Banjade, Ashish; Sapkota, Suman; Kharel, Smile; Chhetri, Ashmita; Sharma, Dipesh; Subedi, Saphal; Chhetri, Pradip

doi:10.31729/jnma.6809

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…The following studies provide some examples of the changes in lipid parameters seen with overt hypothyroidism [ 28 , 29 , 31 – 33 ]. In one study of 58 individuals presenting with overt hypothyroidism and a mean TSH of 42 mIU/L, 34.5% had high TC levels, 56.9% had high LDL-C levels, 69% had high TG levels, and 62.1% had low HDL-C levels [ 33 ]. Another study examined 268 patients presenting with primary hypothyroidism (mean TSH not provided) who were not receiving lipid-lowering therapy.…”

Section: Lipid Changes With Overt Hypothyroidismmentioning

confidence: 99%

Hypothyroidism, lipids, and lipidomics

Jonklaas

2023

Endocrine

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Purpose Hypothyroidism is a relatively common endocrine disorder and is well documented to be associated with lipid abnormalities. Methods A narrative review was conducted of studies describing the alterations in the lipid profile accompanying both subclinical and overt hypothyroidism. Results Lipid abnormalities are seen with TSH values in the upper end of the accepted reference range, as well as with subclinical and overt hypothyroidism. The degree of lipid derangement is generally proportional to the degree of TSH elevation. Other factors such as age, sex, and body mass index can also influence the pattern of the lipid abnormalities seen. The most robust finding with TSH elevation is increases in the low density lipoprotein cholesterol. Thyroid hormone treatment is efficacious in reversing the lipid abnormalities in both subclinical and overt hypothyroidism. Conclusion Given the association of lipid abnormalities with metabolic and cardiovascular disease, consideration of hypothyroidism as an important non-communicable disease may facilitate studies that test the hypothesis that thyroid hormone treatment to reverse hypothyroidism-associated lipid abnormalities may improve metabolic and cardiovascular outcomes.

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Section: Lipid Changes With Overt Hypothyroidismmentioning

confidence: 99%

Hypothyroidism, lipids, and lipidomics

Jonklaas

2023

Endocrine

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“…Leonidas H et al also showed that elevated TSH levels were associated with elevated LDL-C, LDL/HDL-C, and TC levels, and that TSH abnormalities were a risk factor for abnormal lipid metabolism [40]. Moreover, supplementation with thyroid hormone reversed the increase in lipid levels [41][42][43]. In this study, it was found that there was no signi cant difference in thyroid function in different iodine nutrition levels, and after adjusting for thyroid function, iodine nutrition was still observed to in uence blood lipids.…”

Section: Discussionmentioning

confidence: 99%

Lipid metabolism disturbances in papillary thyroid cancer patients and the relationship with iodine nutrition status

Zhai

Wang

Luo

et al. 2023

Preprint

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Objective: Cancer patients are frequently accompanied by problems in lipid metabolism. Uncertainty exists as to whether changes in serum lipids occur in patients with papillary thyroid cancer (PTC) and their relationship with iodine nutrition remains obscure. The aim of this study was to explore lipid metabolism disturbances in PTC patients and their relationship with iodine nutrition status. Methods: A total of 909 patients who were initially diagnosed with PTC and 183 patients who were initially diagnosed with benign thyroid nodules were enrolled in this study. The serum iodine concentration (SIC), the urine iodine concentration (UIC) and nine serum lipids indicators were measured. The generalized linear model (GLM) together with other statistical methods were used to determine whether there were differences in serum lipids between patients with PTC and those with benign thyroid nodules. Results: After adjusting for baseline information, triglycerides (TG) levels in the control group (4.29±1.21) were significantly higher than in the cancer group (1.59±1.25). The rate of abnormal thyroid function was significantly lower in the patients with PTC than in the patients with benign nodules. In the PTC patients, different clinicopathological features had an impact on thyroid function, as reflected by a significant increase in FT3 in PTC with lymph node metastases, a significant increase in TSH, TGAb, and TPOAb, and a significant decrease in FT4 in PTC with AITD. Correlation analysis revealed weak to moderate correlations between iodine nutritional status, thyroid function, and serum lipids. In benign thyroid nodule patients, LDL-C and ApoB values in patients with benign thyroid nodules were significantly higher in the high SIC group than in the adequate and deficient groups. In PTC patients. ApoE levels in the low UIC group were significantly higher than in the middle and high UIC groups. Mediating effects were used to analyze the effect of iodine nutrition on the serum lipids, it showed that the total and direct effects of iodine nutritional status on serum lipids were significant, and the mediating effect of thyroid function was not significant. Conclusion: TG levels in the control group were significantly higher than in the PTC group. Iodine nutritional status influences lipids, and an excess or deficient iodine nutrition increases the risk of dyslipidemia in patients with thyroid nodule. Iodine nutritional status had a direct effect on serum lipids.

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“…ApoAV is crucial to the control of TG. Levels of TGs may potentially be explained by decreased ApoAV activity in hypothyroidism [63].…”

Section: Tag/hdlmentioning

confidence: 99%

Different novel biomarkers involved in diagnosing hypothyroidism

Sharma

Kakadiya

2023

Egypt J Intern Med

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Hypothyroidism is a clinical condition caused by the deficiency of thyroid hormones that are T4 and T3 due to an increase in serum TSH level. The upper and lower limit of T4 and TSH helps to identify the disease. The metabolic pathways are important to know for diagnostic tests. By conducting different biochemical tests, a proper diagnosis can be performed when hypothyroidism is suspected clinically. Previously, many assays were performed just to detect the disease but recent tests are in both direct and indirect categories. Direct tests are purposely enough to detect the deficiency of thyroid hormones just like T3, T4, serum TSH, free-T4, free-T3, T4 resin uptake, free T4 index, T4 binding globulin, and anti-TPO. All these tests are performed considering the reference ranges of hormones and the discovery that lower and higher TSH readings, even within the standard range, could predict future hypothyroidism, respectively, while the connection is stronger for hypothyroidism, supports the significance of diagnosing moderate thyroid status problems. If needed, one can also consider the radiological test that is a radioactive iodine uptake test. Other biochemical tests are considered as indirect because these tests actually confirm other changes in the body due to hypothyroidism such as lipid profile tests (TC, TAG, HDL-C, TC/HDL-C, and TAG/HDL-C), cytokine tests (interleukin-6, TNF-α, visfatin, and leptin) and other regular tests like iron deficiency test, hemoglobin test, ferritin, and TIBC. This article carries brief information regarding all the tests mentioned above and their purpose of conduction in hypothyroidism disease.

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Lipid Profile Abnormalities in Newly Diagnosed Primary Hypothyroidism in a Tertiary Care Centre of Western Nepal: A Descriptive Cross-sectional Study

Cited by 6 publications

References 12 publications

Hypothyroidism, lipids, and lipidomics

Hypothyroidism, lipids, and lipidomics

Lipid metabolism disturbances in papillary thyroid cancer patients and the relationship with iodine nutrition status

Different novel biomarkers involved in diagnosing hypothyroidism

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