Lipid profile: causal relationship on cognitive performance in multiple sclerosis?

Hernández-Ledesma, Ana Laura; Rodríguez-Méndez, Adriana Jheny; Vidal, Lilia Susana Gallardo; García-Gasca, Teresa; Alatorre-Cruz, Julia María; García‐Solís, Pablo; Reyes, Julián López; Solís-Sainz, Juan Carlos

doi:10.1007/s11033-020-06011-3

Cited by 13 publications

(2 citation statements)

References 46 publications

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“…Metabolic alterations, including dyslipidemia, have already been suggested in this disease. Recent published data show that MS patients with a similar age range to the present sample (between 40 and 55 years) also had at-the-limit or above recommended TC and LDL levels [10,13,44,45]. The altered regulation of lipid metabolism in MS may be partly due to nutritional habits, which negatively influences the disease as already seen in a previous publication for this same group of patients [46].…”

Section: Discussionsupporting

confidence: 79%

Lipid Profile in Multiple Sclerosis: Functional Capacity and Therapeutic Potential of Its Regulation after Intervention with Epigallocatechin Gallate and Coconut Oil

de la Rubia Ortí,

Platero Armero,

Cuerda-Ballester

et al. 2023

Foods

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Background: Multiple sclerosis (MS) patients present dyslipidemia and functional disability. Epigallocatechin gallate (EGCG) and coconut oil have been shown to be effective against dyslipidemia. Objective: To analyze the relationship between lipid profiles, fat consumption, and functional disability in patients with MS after administering EGCG and coconut oil. Methods: A four-month pilot study was conducted on 45 MS patients, divided into an intervention group (IG) and a control group (CG). The IG received 800 mg of EGCG and 60 mL of coconut oil. Lipid profiles were measured before and after the intervention, along with other data such as dietary habits, inflammatory markers, and functional capacity. Results: Dyslipidemia did not correlate with the patients’ fat consumption. After the intervention, triglycerides (TG) levels were lower in IG compared to CG. This decrease was positively correlated with an improvement in functional disability (determined by the Expanded Disability Status Scale (EDSS)) and negatively with high-density cholesterol (HDL) and apolipoprotein A1. Significant and positive correlations were observed between EDSS and C-reactive protein (CRP) in the IG. These changes in the IG could be related to body fat decrease, whose percentage shows a positive correlation with CRP and TG levels, and a negative correlation with HDL levels. Conclusions: Patients with MS present a certain type of dyslipemia not associated with their nutritional habits. The administration of EGCG and coconut oil seems to decrease blood TG levels, which could explain the functional improvements.

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Section: Discussionsupporting

confidence: 79%

Lipid Profile in Multiple Sclerosis: Functional Capacity and Therapeutic Potential of Its Regulation after Intervention with Epigallocatechin Gallate and Coconut Oil

de la Rubia Ortí,

Platero Armero,

Cuerda-Ballester

et al. 2023

Foods

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“…These data suggest how much the symptom fatigue can influence the psychosocial and cognitive aspect of MS patients. Although, the observed increase in the lipid profile might indicate that apparently the administration of the two nutritional supplements did not affect the cognitive impairment of the patients [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

Pasquale¹,

Francesco²,

Shevchenko

et al. 2021

Medical Sciences

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Despite recent advances in immune-modulatory drugs, pharmacological therapies have been proven ineffective in severe presentations of multiple sclerosis (MS), including secondary progressive MS. At present, therapeutic interventions’ performance is primarily focused on ameliorating symptoms to improve the patient’s quality of life (QOL). Among complementary treatments, nutrition has been considered a decisive factor to control symptoms and enhance the wellness of MS patients. Although no special diets are associated with MS, the impact of diet and dietary supplements on the course of progressive forms of the disease has been studied during the last few years. Fatigue is among the most common and disabling symptoms reported by MS patients. Fatigue has been defined in the Multiple Sclerosis Council for Clinical Practice Guidelines (MSCCPG, 1998) as a “subjective lack of physical and/or mental energy that the individual perceives as an interference with habitual and desired activities”. This study aimed to compare the psychometric functioning of the “Fatigue Severity Scale” (FSS) and the “Modified Fatigue Impact Scale” (MFIS) in our sample of people with MS. Specifically, during chronic treatment, the change in these two parameters with two vitamin-rich dietary supplements (Citozym® and Ergozym®) was evaluated. The impact of these nutritional supplements revealed differences in antioxidant and anti-inflammatory parameters among the volunteers in the treatment group, with a subsequent improvement in fatigue. In conclusion, the results obtained have confirmed the effectiveness of complementary nutritional therapies, evaluated essentially based on hematological biomarkers, through which it is possible to act on disability to improve the QOL of MS patients.

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Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

Jellinger

2024

J Neural Transm

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Lipid profile: causal relationship on cognitive performance in multiple sclerosis?

Cited by 13 publications

References 46 publications

Lipid Profile in Multiple Sclerosis: Functional Capacity and Therapeutic Potential of Its Regulation after Intervention with Epigallocatechin Gallate and Coconut Oil

Lipid Profile in Multiple Sclerosis: Functional Capacity and Therapeutic Potential of Its Regulation after Intervention with Epigallocatechin Gallate and Coconut Oil

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

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