Lipidomic analysis reveals the efficiency of Eclipta prostrata on diet-induced nonalcoholic fatty liver disease in rats

Hussein, Noha Said; Helmy, Azza Salah; Sherif, Naglaa M.; Ghanem, Hassan Z.; Ibrahim, Nabaweya A.; Gendy, Abdel Nasser G. El; Abdel-Hamid, Abdel-Hamid Z.

doi:10.1016/j.jpba.2018.11.060

Cited by 12 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, Cer plays an important role in the occurrence and progression of NAFLD. Our results reveal that several Cer species are markedly increased in the WD group, which is consistent with the results of other studies 24,50. HBG administration effectively reversed the abnormal liver levels of several SLs, particularly those belonging to the Cer/AS, Cer/ AP, Cer/ADS, HexCer/NS, and SHexCer classes.…”

supporting

confidence: 93%

“…23 Lipidomics analysis also demonstrated the effect of Eclipta prostrata extract on NAFLD in rats, revealing that chitosan oligosaccharide dramatically decreased the levels of toxic hepatic lipids, including TGs and FFAs. 24 These results suggest that it may be possible to use lipidomics to examine the distribution of lipids in biofluids and tissues, uncover and identify the structures of various lipid species, and to measure differences in lipids between different biological samples. 27 However, there are presently no reports on the use of lipidomics to investigate the efficacy of BG, or to clarify lipid biomarkers related to the biological activities of BG in preventing NAFLD.…”

Section: ■ Introductionmentioning

confidence: 97%

“…Lipidomics provides a powerful methodology by which lipid composition can be determined, and unique lipid biomarkers associated with many metabolic diseases (i.e., diabetes, cardiovascular diseases, and NAFLD) can be identified at a molecular level . An analysis of lipidomic changes could provide valuable information regarding the biological activities of functional foods or natural medicines. − In addition, these methods can be used for disease diagnosis in human studies (or animal experiments), and for investigating the effects of therapeutic interventions . Previous lipidomic analyses revealed that NAFLD is associated with an abnormal increase of major lipids [e.g., free fatty acid (FFA), diacylglycerols, and triacylglycerol (TG)] in human and mouse livers. , …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hepatic Lipidomics Analysis Reveals the Ameliorative Effects of Highland Barley β-Glucan on Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice

Liu

Chen

Xie

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is characterized by marked imbalances in lipid storage and metabolism. Because the beneficial health effects of cereal β-glucan (BG) include lowering cholesterol and regulating lipid metabolism, BG may alleviate the imbalances in lipid metabolism observed during NAFLD. The aim of our study was to investigate whether BG from highland barley has an effect on western diet-induced NAFLD in mice. Using lipidomics, we investigated the underlying mechanisms of BG intervention, and identified potential lipid biomarkers. The results reveal that BG (300 mg/kg body weight) significantly alleviated liver steatosis. Lipidomics analysis demonstrated that BG also altered lipid metabolic patterns. We were able to identify 13 differentially regulated lipid species that may be useful as lipid biomarkers. Several genes in the hepatic lipid and cholesterol metabolism pathways were also modulated. These findings provide evidence that BG ameliorates NAFLD by altering liver lipid metabolites and regulating lipid metabolism-related genes.

show abstract

supporting

confidence: 93%

Section: ■ Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatic Lipidomics Analysis Reveals the Ameliorative Effects of Highland Barley β-Glucan on Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice

Liu

Chen

Xie

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…The TGs consist of a glycerol backbone to which three acylated FAs are attached (Yuan et al, 2021;Wang et al, 2022). The positions of FA attachment are, respectively, named by stereospecific numbers, sn-1, sn-2, and sn-3 in sequence from top to bottom, and the stereospecific positions of individual FAs are key to determine the fate of the TG metabolism (Hussein et al, 2019;He et al, 2021). Therefore, the location of FAs on the glycerol backbone is of importance for fish to use lipids (Liu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Lipidomics is a mass spectrometry-based technology, which enables to accurately detect the complete lipid profile, functions, and structures within a tissue; thus, it is a tool to investigate metabolic dysfunction associated with metabolic diseases, such as fatty liver, diabetes, and cardiovascular diseases (Hussein et al, 2019;Liu et al, 2019;He et al, 2021). Nevertheless, there are few reports on the role of lipid molecules in the fish lipid metabolism based on lipidomics.…”

Section: Introductionmentioning

confidence: 99%

Lipidomic Profiling Reveals the Reducing Lipid Accumulation Effect of Dietary Taurine in Groupers (Epinephelus coioides)

Bai

Wang

Niu

et al. 2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

A lipidomic analysis was conducted to provide the first detailed overview of lipid molecule profiles in response to dietary lipid and taurine and associations of liver lipid-lowering effects of dietary taurine with lipid molecular species and the positional distributions of fatty acids in the liver of juvenile orange-spotted groupers (Epinephelus coioides). The results indicated that the liver was more sensitive to varied dietary lipid and taurine contents than the muscle with regard to lipid molecules. A total of 131 differential lipid molecules (DLMs) were observed in the liver of groupers when dietary taurine was increased from 0 to 1% at 15% lipid, among which all the up and down-regulated DLMs are phospholipids (PLs) and triglycerides (TGs), respectively. The liver content of TGs containing 18:2n-6 attached at the sn-2 and sn-3 positions on the glycerol backbone increased with increasing dietary lipid from 10 to 15% but decreased with increasing dietary taurine from 0 to 1%. Therefore, dietary taurine can not only reduce lipid accumulation through decreasing the contents of TGs containing 18:2n-6 at the sn-2 and sn-3 positions but also enhance the anti-inflammatory capacity and health status of groupers. This study will also provide a new insight into the function of taurine in farmed fish.

show abstract

Regulation of SIRT1-TLR2/TLR4 pathway in cell communication from macrophages to hepatic stellate cells contribute to alleviates hepatic fibrosis by Luteoloside

Xiu¹,

Zhao²,

Wang³

et al. 2023

Acta Histochemica

View full text Add to dashboard Cite

Lipidomic analysis reveals the efficiency of Eclipta prostrata on diet-induced nonalcoholic fatty liver disease in rats

Cited by 12 publications

References 24 publications

Hepatic Lipidomics Analysis Reveals the Ameliorative Effects of Highland Barley β-Glucan on Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice

Hepatic Lipidomics Analysis Reveals the Ameliorative Effects of Highland Barley β-Glucan on Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice

Lipidomic Profiling Reveals the Reducing Lipid Accumulation Effect of Dietary Taurine in Groupers (Epinephelus coioides)

Regulation of SIRT1-TLR2/TLR4 pathway in cell communication from macrophages to hepatic stellate cells contribute to alleviates hepatic fibrosis by Luteoloside

Contact Info

Product

Resources

About