Lipids and atherosclerosis

Halpern, M. J.

doi:10.1016/0098-2997(95)00004-6

Cited by 10 publications

(4 citation statements)

References 785 publications

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“…However, not only the concentration of cholesterol in the blood is of importance, but also the lipoprotein profile. Numerous epidemiological and clinical trials have demonstrated a negative correlation between serum high-density lipoprotein (HDL) cholesterol levels and the development of atherosclerosis (7). We have shown previously that a genetic factor affecting basal serum HDL cholesterol level is located on LG VI, near Est-2 and Es-1 (32).…”

Section: Discussionmentioning

confidence: 99%

Mapping of microsatellite loci and association of aorta atherosclerosis with LG VI markers in the rabbit

Korstanje

Gillissen

Kodde

et al. 2001

Physiological Genomics

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Twenty-three rabbit microsatellites were extracted from the EMBL nucleotide database. Nine of these markers, together with nine earlier published microsatellite markers, were found to be polymorphic between the AX/JU and IIIVO/JU inbred strains. By using an F(2) intercross we could integrate five markers into the rabbit linkage map. One anonymous microsatellite marker could be assigned to chromosome 1, and one microsatellite marker, located within the metallothionein-1 gene, could be added to linkage group VI (LG VI). Three microsatellite markers (one anonymous, one located within the PMP2 gene, and one located within the FABP6 gene) constitute a new linkage group (LG XI). We also measured the degree of dietary cholesterol-induced aorta atherosclerosis in the F(2) animals. A significant cosegregation was found between the degree of aorta atherosclerosis and the allelic variation of the biochemical marker Est-2 on LG VI in male rabbits. This association was not found in female rabbits.

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Section: Discussionmentioning

confidence: 99%

Mapping of microsatellite loci and association of aorta atherosclerosis with LG VI markers in the rabbit

Korstanje

Gillissen

Kodde

et al. 2001

Physiological Genomics

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“…Hypercholesterolaemia is recognised as a major and independent risk factor of atherosclerosis and CVD ( 2 ) . About 60–70 % of plasma cholesterol is present in the LDL fraction ( 3 ) . Plasma LDL-cholesterol (LDL-C) crosses the endothelial barrier and reaches the vascular subendothelial intima, whereby promoting monocyte/macrophage differentiation.…”

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confidence: 99%

Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats

et al. 2011

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In the present study, we aimed to examine the effects of soya oligosaccharides (SOS) and soya oligopeptides (SOP) on blood lipid levels, release of vasoactive substances, antioxidant activity and faecal bile acid (FBA) excretion in rats fed a high-fat diet (HFD). Male SpragueDawley rats were evenly divided into five groups according to diets as follows: regular diet (control), HFD, HFD enriched with 2 % of SOS (SOS), HFD enriched with 3 % of SOP (SOP) and HFD enriched with 2 % SOS and 3 % SOP (SOSP). The results showed that SOS and SOP significantly reduced plasma total cholesterol, LDL-cholesterol and TAG, whereas HDL-cholesterol concentration was significantly increased. Furthermore, SOS and SOP reduced plasma apoB, apoE and the apoB:apoAI ratio, whereas apoAI was significantly increased. Moreover, SOS and SOP also reduced plasma thromboxane A 2 (TXA 2 ) and the TXA 2 :prostacyclin (PGI 2 ) ratio, whereas plasma PGI 2 and nitric oxide were significantly increased. In addition, SOS and SOP significantly reduced serum and liver malondialdehyde concentrations and increased FBA excretion. However, we did not observe obvious influences of SOS and SOP on superoxide dismutase activities in the liver of HFD-fed rats. The combination of 2 % SOS and 3 % SOP showed a more marked effect than SOS or SOP alone in improving the lipid profile, release of vasoactive substances and increasing FBA excretion (P,0·05). In summary, SOS and SOP might help prevent atherosclerosis through improving abnormal blood lipid levels, regulating vasoactive substances and protecting against oxidative stress.

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“…With the accelerating pace of globalization, the demand for cyclohexanone, which is an important industrial solvent widely used in oil paint, pesticide, dye, aviation fuel and so on, is increasing [1][2][3][4][5][6] . However, it will discharge massive wastewater in the production process of cyclohexanone, and the effluent contains hazardous materials such as cyclohexanone and cyclohexane which can harm the vessel of human body resulting in coagulation necrosis of viscera and brain [7][8][9][10][11][12]. It may bring harm to human health and destroy ecological environment if the wastewater has not been disposaled effectively [13][14][15][16][17][18][19][20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Removal Efficiency of Hazardous Material in Cyclohexanone Production Wastewater Applying Anaerobic Upflow Bed Filter

Liu

2010

AMR

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The cyclohexanone production wastewater includes hazardous material such as cyclohexanone and cyclohexane which can harm the vessel of human body resulting in coagulation necrosis of viscera and brain. Our experiment choosed the cyclohexanone production wastewater to be investigated, and used the self-made anaerobic upflow bed filter (UBF) to deal with it. We try to find the optimal operational parameters which can make the degradation of hazardous materials maximizing. The COD removal efficiency was decreasing with the COD of influent’s increasing in starting stage, the shock load made the microbe in UBF can’t adapt the high VLR temporarily. In the running stage, the anaerobic sludge in UBF was incompact and the settleability of sludge was not very well. As the UBF running, the granular sludge shaped up greatly, the COD removal efficiency kept on 80%. The result showed that the UBF reactor was valid for hazardous material in cyclohexanone production wastewater.

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Lipids and atherosclerosis

Cited by 10 publications

References 785 publications

Mapping of microsatellite loci and association of aorta atherosclerosis with LG VI markers in the rabbit

Mapping of microsatellite loci and association of aorta atherosclerosis with LG VI markers in the rabbit

Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats

Removal Efficiency of Hazardous Material in Cyclohexanone Production Wastewater Applying Anaerobic Upflow Bed Filter

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