Lipids isolated from the cultivated red alga Chondrus crispus inhibit nitric oxide production

Banskota, Arjun H.; Stefanova, Roumiana; Sperker, Sandra; Lall, Santosh P.; Craigie, J. S.; Hafting, Jeff T.

doi:10.1007/s10811-013-0174-5

Cited by 50 publications

(54 citation statements)

References 26 publications

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“…SQMGs were never before reported in the lipidome of seaweeds from the genus Gracilaria . Glycolipids have already been identified for members of the Rhodophyta (red seaweeds), namely in the genus Gracilaria [21,30,40,41,42]. However, the majority of published works only identified a few species of glycolipids, either by using offline TLC–MS [30,40,42,43] or selected solvent extraction and MS analysis [15,20,29].…”

Section: Resultsmentioning

confidence: 99%

“…Accordingly, polar lipids isolated from red algae have demonstrated strong anti-inflammatory activity, even higher when compared with pure 20:5( n -3) FA isolated from the same extracts [43], suggesting that the polar lipid itself may contribute to the anti-inflammatory activity. In the cases of Chondrus crispus and Palmaria palmata (Linnaeus) Weber & Mohr, 1805, the polar lipids such as glycolipids and phospholipids showed NO inhibitory activity through downregulation of inducible nitric oxide synthase (iNOS) [20,21,57]. Moreover, extracts rich in glycolipids bearing high proportions of PUFA, isolated from the red seaweeds Palmaria palmata , Porphyra dioica J. Brodie & L. M. Irvine, 1997, and Chondrus crispus , downregulated LPS-induced pro-inflammatory responses in human macrophages through the inhibition of IL-6 and IL-8 production, thus inferring their potential anti-inflammatory activity [15].…”

Section: Resultsmentioning

confidence: 99%

“…In what concern anti-inflammatory activities, Banskota et al reported that the extracts rich in MGDG and DGDG isolated from red seaweed Chondrus crispus inhibited NO production through downregulation of iNOS [21]. The enriched extract contained MGDG (20:5/20:5), MGDG (20:5/20:4), MGDG (18:4/16:0), MGDG (20:4/16:0), and MGDG (20:5/16:0) and the respective DGDG analogues.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies reported that polar lipids isolated from seaweeds can promote growth-inhibiting effects on human hepatocellular carcinoma cell lines (HepG2) [16] and thus can act as inhibitors of DNA polymerases with capability to inhibit tumor cell proliferation [17]. Moreover, they have been associated with anti-inflammatory properties through the inhibition of pro-inflammatory cytokines interleukin IL-6 and IL-8 production [15] and/or by the inhibition of nitric oxide (NO) production [18,19,20,21]. Lipid-based agents are therefore emerging molecules in therapeutics aimed to regulate inflammatory pathways or even impair downstream tumorigenic processes [22,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

et al. 2017

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The lipidome of the red seaweed Gracilaria sp., cultivated on land-based integrated multitrophic aquaculture (IMTA) system, was assessed for the first time using hydrophilic interaction liquid chromatography-mass spectrometry and tandem mass spectrometry (HILIC–MS and MS/MS). One hundred and forty-seven molecular species were identified in the lipidome of the Gracilaria genus and distributed between the glycolipids classes monogalactosyl diacylglyceride (MGDG), digalactosyl diacylglyceride (DGDG), sulfoquinovosyl monoacylglyceride (SQMG), sulfoquinovosyl diacylglyceride (SQDG), the phospholipids phosphatidylcholine (PC), lyso-PC, phosphatidylglycerol (PG), lyso-PG, phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatic acid (PA), inositolphosphoceramide (IPC), and betaine lipids monoacylglyceryl- and diacylglyceryl-N,N,N-trimethyl homoserine (MGTS and DGTS). Antiproliferative and anti-inflammatory effects promoted by lipid extract of Gracilaria sp. were evaluated by monitoring cell viability in human cancer lines and by using murine macrophages, respectively. The lipid extract decreased cell viability of human T-47D breast cancer cells and of 5637 human bladder cancer cells (estimated half-maximal inhibitory concentration (IC50) of 12.2 μg/mL and 12.9 μg/mL, respectively) and inhibited the production of nitric oxide (NO) evoked by the Toll-like receptor 4 agonist lipopolysaccharide (LPS) on the macrophage cell line RAW 264.7 (35% inhibition at a concentration of 100 μg/mL). These findings contribute to increase the ranking in the value-chain of Gracilaria sp. biomass cultivated under controlled conditions on IMTA systems.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

et al. 2017

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“…Galactolipids as shown were responsible for the anti-tumour promoting activity of jute, a well-known medicinal vegetable in North Africa and Asia [63]. Intensive study of algae showed that their GL also exhibit different biological activity, for example, anti-tumour [64] [65], anti-inflammatory [66] [67], antiviral [26], and antibacterial [25] [68] activities that continues to attract attention to these substances. As shown previously, the GL contents in S. pallidum were close enough in March and in August [43].…”

Section: Seasonal Changes In Contents Of Lipids Classesmentioning

confidence: 99%

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health

Gerasimenko¹,

Logvinov²

2016

OJMS

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The present study describes the content of total lipids (TL), the main components of polar and neutral lipids (NL) and photosynthetic pigments (PSP) in edible seaweed Sargassum pallidum (Ochrophyta) from the Sea of Japan, Russia, in different months of the year, taking into account life cycle. Special attention was paid to the fatty acids (FAs) of total lipids as well as the accumulation of important polyunsaturated fatty acids (PUFAs) in glyceroglycolipids (GL) and reserve lipids in the seasonal cycles of growth. The content of TL strongly varied in the course of a year. The major lipid components were GL (20.3% -36.4%) and NL (19.8% -30.6%), while phospholipids (PL) were present in negligible amounts (3.2% -6.9%). Significant seasonal variations were observed in content all classes of lipids. The PUFAs prevailed in total lipids and the content of n-6 PUFAs was higher than n-3 PUFAs on all stages of life with the exception of vegetation period. Monogalactosyldiacylglycerols (MGDG) and digalactosyldiacylglecerols (DGDG) were rich in PUFAs and n-3 PUFAs were dominated among them independently of stages of growth. Saturated fatty acids (SFA) were dominated in sulfoquinovosyldiacylglycerols (SQDG). Triacylglycerols (TAG) and diacylglycerols (DAG) contained many PUFAs, especially n-6 PUFAs. Significant concentration 20:3 n-6 was in the triacylglycerols. The concentration of chlorophylls and carotenoids was increased with the growth and maturation of S. pallidum and reached maximum in period of highest day length and water temperature. The content of pigments decreased with the onset of short days and decreasing water temperatures. Nutritional value and benefit for health of human this alga were evaluated. The n-6/n-3 PUFAs ratio, nutritional quality index (atherogenic and thrombogenic indices, and ratio between hypocholesterolemic and hypercholesterolemic fatty acids) were low, suggesting a high nutritional value of S. pallidum throughout the year.

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Algal Derived Functional Lipids and their Role in Promoting Health

Terme

Chénais

Fournière

et al. 2021

Recent Advances in Micro and Macroalgal Processing

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Algae are organisms with an enormous biodiversity and contain manifold fatty acid molecular structures and ratios. This chapter presents information about the structure and distribution of fatty acids in algae whether microalgae or macroalgae. The parameters affecting lipid and fatty acid contents as well as distribution are also discussed. Methods for isolation and purification of fatty acids from algae to obtain highly pure fatty acid or fatty acid fractions with good overall yields are presented. Algal fatty acids are known as sources of bioactive compounds for health promotion and wellness. Lipid fractions and fatty acids act as actives or additives for cosmeceutical applications. For health promotion, preventive effects of n-3 polyunsaturated fatty acids on cardiovascular disease, metabolic syndrome and cancer are discussed. The role of n-3 fatty acids in cancer therapy and antiviral activities of lipids are also exposed. Furthermore, potential commercial application domains and concepts are discussed in this chapter.

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Lipids isolated from the cultivated red alga Chondrus crispus inhibit nitric oxide production

Cited by 50 publications

References 26 publications

Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health

Algal Derived Functional Lipids and their Role in Promoting Health

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Lipids isolated from the cultivated red alga Chondrus crispus inhibit nitric oxide production

Cited by 50 publications

References 26 publications

Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga &lt;i&gt;Sargassum pallidum&lt;/i&gt;: The Potential for Health

Algal Derived Functional Lipids and their Role in Promoting Health

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Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health