Lipoblast: Morphologic Features and Diagnostic Value

Hisaoka, Masanori

doi:10.7888/juoeh.36.115

Cited by 25 publications

(15 citation statements)

References 23 publications

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“…Lipoblasts are conceptually an immature or precursor form of adipocytes and are essentially identified in neoplastic conditions (12). Traditionally, great emphasis has been placed on the identification of lipoblasts as a diagnostic marker for liposarcoma (10).…”

Section: Discussionmentioning

confidence: 99%

“…The nucleus of a lipoblast may be pushed aside by a single large lipid vacuole, resulting in a signet-ring configuration, or it may remain centrally located with small indentations caused by multiple, small vacuoles, resulting in an appearance similar to that of sebaceous cells or adrenal spongiocytes. In addition to the above typical lipoblast characteristics, atypical or giant forms having large, irregular or multiple nuclei may be present (12).…”

Section: Definitionsmentioning

confidence: 99%

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Infiltration characteristics and influencing factors of retroperitoneal liposarcoma: Novel evidence for extended surgery and a tumor grading system

Wang

et al. 2018

BST

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This study sought to evaluate the infiltration tendency of retroperitoneal liposarcoma (RPLS) from a new pathological angle by exploring the infiltration characteristics, which could provide helpful information to facilitate surgical decision-making and prognosis prediction. Concurrently, we aim to identify significant indicators of infiltration. A total of 61 consecutive patients with RPLS at our institution were retrospectively analyzed. All patients received extended surgery. The tumor infiltration characteristics and influencing factors were studied based on the pathological diagnosis. Univariate and multivariate analyses of organ infiltration (OI) and surrounding fat infiltration (SFI) were performed. OI was found in 95 (28.5%) resected organs from 39 (60.7%) patients, and SFI was found in 119 (35.7%) resected organs from 47 (77%) patients. The tumor infiltrated the serosal layer of 13 organs (13/37, 35.1%), the muscularis layer of 18 organs (18/37, 48.6%) and the submucosa of 6 organs (6/37, 16.2%). The percentage of lipoblasts and the rates of necrosis and mitosis were all significantly higher in high-grade tumors (dedifferentiated, round cell, and pleomorphic). A high lipoblast percentage (≥ 20%) was the only independent risk factor for OI. A recurrent tumor and a high-grade tumor were independent risk factors for SFI. In conclusion, RPLS has a high infiltration tendency, such that it frequently infiltrates organs and surrounding fat tissue. Therefore, extended resection of the tumor and the adjacent organs is recommended. The percentage of lipoblasts was associated with the tumor grade and infiltration characteristics; thus, lipoblast percentage may become a new grading factor for RPLS.

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Section: Discussionmentioning

confidence: 99%

Section: Definitionsmentioning

confidence: 99%

Infiltration characteristics and influencing factors of retroperitoneal liposarcoma: Novel evidence for extended surgery and a tumor grading system

Wang

et al. 2018

BST

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“…Histopathological ndings in the multivariate analysis showed that lipoblasts were statistically signi cant for the diagnosis of ALT/WDLS. Traditionally, lipoblasts have been emphasized as a histopathological nding in the diagnosis of liposarcoma [36]. However, lipoblasts are also observed in benign lipogenic tumors such as spindle cell/pleomorphic lipoma.…”

Section: Discussionmentioning

confidence: 99%

A scoring system combining clinical, radiological, and histopathological examinations for differential diagnosis between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma

Asano

Miwa

Yamamoto

et al. 2021

Preprint

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Background: Preoperative differential diagnosis between atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLS) and lipoma is important to determine the appropriate resection margin. However, since their radiological and histopathological findings are similar, it may be difficult to make a differential diagnosis. In this study, we evaluated the diagnostic accuracies of clinical, radiological, and histopathological examinations for diagnosing ALT/WDLS and developed a new combined scoring system.Methods: Eighty-nine ALT/WDLS and 56 lipomas were included and their clinical characteristics, magnetic resonance imaging (MRI) findings, histological findings by hematoxylin and eosin (HE) staining were investigated, and compared between ALT/WDLS and lipoma. Then, univariate analyses and multivariate logistic regression analyses were performed for the findings, and a combined scoring system consisted of predictive factors of ALT/WDLS was developed. Results: The univariate and multivariate logistic regression analyses revealed that tumor location (lower extremity), deep site, and size (>11cm), thick septa (>2mm), enhancement of septa or nodular lesions on MRI, and lipoblasts in HE staining were significantly different for the diagnosis of ALT/WDLS. Based on the six predictive factors, we developed a combined scoring system (total 0–16 points, the cutoff was 9 points). The mean score of ALT/WDLS was significantly higher than lipoma (11.9 vs. 5.6, p<0.0001). The area under the curve was 0.945, and sensitivity was 87.6% and specificity was 91.1% by the receiver operating characteristics curve.Conclusions: We developed a new combined scoring system based on comprehensive examinations that excluded examination which requires special equipment and reagents such as fluorescence in situ hybridization (FISH), and this can be used in many medical institutions. The diagnostic accuracy of ALT/WDLS was high and it may be useful for preoperative diagnosis and surgical plan.

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“…Chung and Enzinger described infiltration into the surrounding skeletal muscle and lesser lobulation as important features differentiating lipoblastomatosis from typical lipoblastoma (8). Lipoblast is a unique mesenchymal cell that ranges in morphology from an immature fat cell resembling fibroblast to a mature fat cell with lipid droplets throughout its cytoplasm (9). There are many histomorphological mimics of lipoblasts which pose difficulty in making the correct diagnosis (Table 1) (9).…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Congenital Perineal Lipoma-like Lipoblastoma

et al. 2019

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Introduction: Adipocytic tumors and its variants are common neoplasms of adults; however, they are rarely seen in paediatric age group, too. Lipoblastoma typically occurs in children and are diagnosed by the presence of a multivacuolated lipoblast. However, things get complicated when one has to search for these lipoblasts in a background of classical lipoma. As a result, such cases are misdiagnosed and managed inappropriately. We report the first case of a congenital lipoma like lipoblastoma with an unusual presentation.Case Presentation: A 10-day-old male was admitted to the Paediatric Surgery Outpatient Department with a mass in his perianal region since birth. On examination, the mass was nontender, pedunculated, and located at the margin of the anal opening. A provisional clinical diagnosis of anal tag was made, and swelling was excised. Grossly, we received a skin covered soft tissue mass measuring 1.2cm in diameter. The cut section was yellow and had a soft to firm consistency. Histopathological examination showed a well-delineated moderately cellular lesion comprising of lobules of adipocytes in varying stages of maturation; large number of mature adipocytes and few interspersed multivacuolated lipoblasts. A final diagnosis of lipomalike lipoblastoma was made. Conclusion:Lipoma-like lipoblastoma can be seen as a congenital mass and at unusual sites like the perianal region. An accurate diagnosis of this entity is essential for appropriate management. Histopathology is the gold standard for diagnosis and calls for increased awareness.

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Lipoblast: Morphologic Features and Diagnostic Value

Cited by 25 publications

References 23 publications

Infiltration characteristics and influencing factors of retroperitoneal liposarcoma: Novel evidence for extended surgery and a tumor grading system

Infiltration characteristics and influencing factors of retroperitoneal liposarcoma: Novel evidence for extended surgery and a tumor grading system

A scoring system combining clinical, radiological, and histopathological examinations for differential diagnosis between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma

Congenital Perineal Lipoma-like Lipoblastoma

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