Lipoblastoma presenting as a rapidly growing paravertebral mass and masquerading as myxoid liposarcoma on fine needle aspiration cytology

Selvi, Subramanian Kalaivani; Pradhan, Prita; Ganesh, Rajesh Nachiappa; Gochhait, Debasis; Barwad, Adarsh

doi:10.1002/dc.23435

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Lipoblastomas are the second commonest pediatric adipocytic tumors after lipomas. Magnetic resonance imaging is the modality of choice for evaluation of tumor extension and planning of excision [ 11 , 15 – 17 , 19 , 26 – 28 ]. Majority are 5 cm or less in size.…”

Section: Main Textmentioning

confidence: 99%

Lipoblastoma: a clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature

et al. 2018

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ObjectiveLipoblastoma is a rare neoplasm that occurs mostly in infants and children. Although benign, it has a tendency for local recurrence.ResultsClinical and pathological features of 23 cases of lipoblastoma described. Patients’ age ranged from 8 months to 18 years with mean and median age 4.1 and 2.5 years, respectively. Male:female ratio was 2.8:1. Most common sites were lower extremities (9 cases), followed by abdominal cavity and retroperitoneum (4 cases), and scrotum/groin (3 cases). Grossly, 22 tumors were well circumscribed and multi nodular. All cases showed lobules composed of adipocytes and lipoblasts with intervening fibrous septa and fine vascular network. Myxoid change, capsule formation and septation were seen in all cases. Zonation was seen in 2 cases. Follow-up was available in 14 out of 23 patients. Of these, 13 were alive and free of disease with no evidence of any recurrent lesion. One patient with a mediastinal infiltrating lipoblastoma experienced 4 recurrences. Lipoblastoma is a benign adipocytic neoplasm of infants and young children. Correlation of clinical and histological features helps in reaching a correct diagnosis. Owing to a high recurrence rate following incomplete resection, a complete resection is essential. Prognosis is excellent after complete resection.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3153-8) contains supplementary material, which is available to authorized users.

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Section: Main Textmentioning

confidence: 99%

Lipoblastoma: a clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature

et al. 2018

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“…Previous reports of FNA of lipoblastoma have also highlighted similar myxoid change and delicate capillary network as important morphological features . By contrast, the presence of uni‐/multi‐vacuolated lipoblasts can lead to an over‐diagnosis of myxoid liposarcoma …”

Section: Discussionmentioning

confidence: 94%

Fine needle aspiration cytology of paediatric soft tissue tumours highlighting challenges in diagnosis of benign lesions and unusual malignant tumours

et al. 2019

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Introduction The type of soft tissue lesions seen in children differs from that seen in adults. The role of fine needle aspiration (FNA) cytology in their diagnosis is not well documented. Aim To study the cytopathological spectrum of paediatric soft tissue tumours to highlight uncommon benign and malignant lesions and the challenges in their diagnosis. Methods A 3‐year retrospective audit of all paediatric soft tissue FNA cytology cases from 2015 to 2017 was performed. Smears were reviewed along with cell block immunocytochemistry and follow‐up histopathology of resected specimens wherever available. Results A total of 127 cases were reviewed, which included 72 benign and 55 malignant soft tissue tumours. Uncommon lesions described herein are myxoid fibrohistiocytic tumour, myxoma, lipoblastoma, Bednar tumour, malignant extra‐renal rhabdoid tumour and desmoplastic small round cell tumour. Histopathology confirmation was available in 25 cases, out of which 16 cases were completely concordant. In eight cases, all benign diagnoses, histopathology provided more accurate subtyping than FNA. These included cases of lipoblastoma, myxoma and spindle cell haemangioma. Conclusion FNA cytology of paediatric soft tissue tumours is accurate in classifying lesions as benign or malignant which helps in treatment planning. Immunocytochemistry performed on cell blocks is useful for subtyping malignant lesions.

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“…The most common symptom is a painless mass. 2 Magnetic resonance imaging (MRI) is an important tool for determining the anatomical extent, tissue involvement, and composition of tumors and designing a treatment strategy. The best surgical treatment is a complete resection including the edge of the tumor and long-term follow-up is recommended in case of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Atypical location of lipoblastoma in a 5-year-old girl

Dong

Sun

et al. 2023

Arch Argent Pediat

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We reported a perineal lipoblastoma in a 5-year-old girl located in the right labia mayor. The lesion gradually increased within 6 months. Ultrasound and magnetic resonance imaging (MRI) showed a limited solid heterogenous tumor with fatty component. After it had been surgically removed, the anatomopathological examination confirmed that it was a lipoblastoma.Lipoblastoma is a rare benign mesenchymal tumor of infancy and early childhood. Symptoms vary depending on localization; signs of compression of adjacent organs may be seen. This type of unusual soft tissue tumors occurred most often in under 3 years old. The localization of lipoblastomas is predominantly in the extremities but may be also found in other sites including the head and neck, trunk, mediastinum, kidney, mesentery, retropritoneum and perineum. The suspicion should be considered according to ultrasound and MRI findings.

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Lipoblastoma presenting as a rapidly growing paravertebral mass and masquerading as myxoid liposarcoma on fine needle aspiration cytology

Cited by 7 publications

References 9 publications

Lipoblastoma: a clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature

Lipoblastoma: a clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature

Fine needle aspiration cytology of paediatric soft tissue tumours highlighting challenges in diagnosis of benign lesions and unusual malignant tumours

Atypical location of lipoblastoma in a 5-year-old girl

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