Lipoic Acid Functionalized Silver Nanoprisms for Colorimetric Sensing of γ‐Aminobutyric Acid, Selenite and Myoglobin

Abstract

Silver nanoprisms (AgNPRs) are synthesized by silver nitrate through chemical reduction method using sodium borohydride and hydrogen peroxide. AgNPRs were functionalized with lipoic acid (LA) and successfully integrated with UV‐visible spectrophotometry for simultaneous detection of multiple biomarkers such as γ‐aminobutyric acid (GABA), selenite, and myoglobin. The as‐prepared LA‐AgNPRs exhibited surface plasmon resonance (SPR) characteristic peak at 660 nm. The SPR band of LA‐AgNPRs was blue‐shifted to 439, 390, and 479 nm upon the addition of GABA, selenite, and myoglobin, respectively. The limits of detection are 6.32, 0.35 and 20.40 nM for GABA, selenite, and myoglobin, respectively. The LA‐AgNPRs sensor displays potential prospect to detect three biomarkers GABA, selenite, and myoglobin in biofluid samples.