Lipoic acid nanoforms based on phosphatidylcholine: production and characteristics

Shchelkogonov, V. A.; Alyaseva, S. O.; Lotosh, N. Yu.; Baranova, O. A.; Чеканов, А. В.; Solov’eva, E. Yu.; Камышинский, Р. А.; Василов, Р. Г.; Шастина, Н. С.; Korepanova, E. A.; Аносов, А. А.; Селищева, А. А.

doi:10.1007/s00249-019-01415-x

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…The authors proposed that the slower release from nanoemulsions could be attributed to their multiple-layer structure, whereas liposomes, being primarily single-layered particles, facilitated a faster release. Thus, nanoemulsions might represent a more suitable formulation for α-lipoic acid, prolonging the drug’s action [ 102 ].…”

Section: Enhancement Of α-Lipoic Acid Properties and Activity When En...mentioning

confidence: 99%

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

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α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, and targeted delivery. Nanoformulations of α-lipoic acid can significantly enhance its solubility and absorption, making it more bioavailable. While α-lipoic acid can be prone to degradation in its free form, encapsulation within nanoparticles ensures its stability over time, and its release in a controlled and sustained manner to the targeted tissues and cells. In addition, α-lipoic acid can be combined with other compounds, such as other antioxidants, drugs, or nanomaterials, to create synergistic effects that enhance their overall therapeutic benefits or hinder their potential cytotoxicity. This review outlines the advantages and drawbacks associated with the use of α-lipoic acid, as well as various nanotechnological approaches employed to enhance its therapeutic effectiveness, whether alone or in combination with other bioactive agents. Furthermore, it describes the engineering of α-lipoic acid to produce poly(α-lipoic acid) nanoparticles, which hold promise as an effective drug delivery system.

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Section: Enhancement Of α-Lipoic Acid Properties and Activity When En...mentioning

confidence: 99%

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

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Liposomes as a Targeted Delivery System of Drugs (Review)

Горбик

Shprakh

Козлова

et al. 2021

Rossijskij bioterapevtičeskij žurnal

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Liposomal targeted drug delivery makes it possible to achieve effective concentration in the target cell under various pathological conditions. The main advantage of liposomal particles is their biodegradability and immunological neutrality, which improves the safety profile of drugs. The review provides information on the composition of liposomes: the main component of the liposomal membrane is phospholipids, which provide its strength and protect from mechanical impacts. Liposomal particles are distinguished by the size and number of bilayer membranes, also secreted liposomes with a non‑lamellar organization. The composition and size of liposomes are selected depending on the purpose, including excipients in the membrane that affect the properties and functions of liposomes, including the rate of release of the components, the affinity of liposomes for the target tissue, etc. The review considers the main methods for obtaining liposomes and the features of their use, advantages and disadvantages. The creation of liposomes that are sensitive to various external or internal physicochemical factors makes it possible to realize drugs effects, localize the site of its action and reduce the number and severity of side effects. Currently, liposome‑based drugs are successfully used in various fields of medicine – dermatology, cardiology, oncology, neurology, etc. The most active condact preclinical and clinical studies of liposomal drugs for the treatment of malignant neoplasms. Particular attention is paid to the work of Russian researchers in the field of targeted drug delivery. It is shown that today liposomes are an open for study and improvement system for targeted drug delivery.

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Encapsulation of Alpha-Lipoic Acid in Functional Hybrid Liposomes: Promising Tool for the Reduction of Cisplatin-Induced Ototoxicity

et al. 2022

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In this study, in order to address the drawback of cisplatin (CDDP)-induced ototoxicity, we propose a straightforward strategy based on the delivery of a sulfur-based antioxidant, such as lipoic acid (LA), to HEI-OC1 cells. To this aim, hybrid liposomes (LA@PCGC) with a spherical shape and a mean diameter of 25 nm were obtained by direct sonication of LA, phosphatidylcholine and a gelatin-curcumin conjugate in a physiological buffer. LA@PCGC were found to be stable over time, were quickly (i.e., by 1 h) taken up by HEI-OC1 cells, and guaranteed strong retention of the bioactive molecule, since LA release was less than 20%, even after 100 h. Cell viability studies showed the efficiency of LA@PCGC for stabilizing the protective activity of LA. Curcumin residues within the functional liposomes were indeed able to maintain the biological activity of LA, significantly improving (up to 2.19-fold) the viability of HEI-OC1 cells treated with 5 μM CDDP. Finally, LA@PCGC was incorporated within an alginate-based injectable hydrogel carrier to create a formulation with physical chemical features suitable for potential ear applications.

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Lipoic acid nanoforms based on phosphatidylcholine: production and characteristics

Cited by 3 publications

References 15 publications

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Liposomes as a Targeted Delivery System of Drugs (Review)

Encapsulation of Alpha-Lipoic Acid in Functional Hybrid Liposomes: Promising Tool for the Reduction of Cisplatin-Induced Ototoxicity

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