Lipoma of the heart

Crockett, James E.; Decker, Donald; Reed, William; Dunn, Marvin; Léger, L

doi:10.1016/0002-9149(64)90084-0

Cited by 26 publications

(3 citation statements)

References 8 publications

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“…Additional findings in this patient of lipomatous hypertrophy of the interatrial septum and type IIa hyperlipidemia suggested a generalized syndrome of lipomatous infiltration into multiple tissues and hyperlipidemia. The lipomatous invasion of the myocardium noted in this case is a rare finding; cardiac lipomas are more usually well circumscribed and epicardially restricted (Crockett et al, 1964; Hananouchi and Goff, 1990; Kamiya et al, 1990; Eng et al, 1992; Burke and Virmani, 1996). The unusual lipomatous infiltration suggested that elaboration of the oncogenic etiology for the tumor might reveal novel mechanisms underlying epicardial cell growth.…”

Section: Discussionmentioning

confidence: 79%

A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis

Vaughan

Weremowicz

Goldstein

et al. 2000

Genes Chromosom. Cancer

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Cardiac lipomas occur infrequently but account for a significant portion of rare cardiac tumors. Common cutaneous lipomas have previously been associated with rearrangements of chromosome band 12q15, which often disrupt the high‐mobility‐group protein gene HMGIC. In this report, we describe the cytogenetic analysis of an unusual giant cardiac lipoma that exhibited myocardial invasion in a patient with a history of multiple lipomatosis (cutaneous lipoma, lipomatous gynecomastia, lipomatous hypertrophy of the interatrial septum, and dyslipidemia). Cytogenetic studies of cells derived from the cardiac lipoma demonstrated no abnormalities of chromosome 12, but did reveal a t(2;19)(p13;p13.2). A liposarcoma‐derived oncogene (p115‐RhoGEF) previously mapped to chromosome 19 and the low‐density lipoprotein receptor gene (LDLR) previously mapped to chromosome band 19p13 were evaluated to determine whether they were disrupted by this translocation. Fluorescence in situ hybridization analyses assigned p115‐RhoGEF to chromosome 19 in bands q13.2–q13.3 and mapped the LDLR to chromosome arm 19p in segment 13.2, but centromeric to the t(2;19) breakpoint. Thus, these genes are unlikely to be involved in the t(2;19)(p13;p13.2). Further studies of the regions of chromosomes 2 and 19 perturbed by the translocation in this unusual infiltrating cardiac lipoma will identify gene(s) that participate in adipocyte growth and differentiation and may provide insight into syndromes of multiple lipomatosis. Genes Chromosomes Cancer 28:133–137, 2000. © 2000 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 79%

A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis

Vaughan

Weremowicz

Goldstein

et al. 2000

Genes Chromosom. Cancer

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“…Half of the lipomas originate from the subendocardium, a quarter from the subpericardium and a quarter from the myocardium 6 7. Cardiac lipomas are often asymptomatic, unless the mass compromises cardiac function.…”

Section: Discussionmentioning

confidence: 99%

Incidental finding of giant pericardial lipoma

et al. 2016

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“…Lipomas can occur at any age, typically seen in fifth and sixth decades of life, and affects both genders equally ( 5 – 7 ). Cardiac lipomas can originate either from the subendocardium (approximately 50%), subpericardium (25%), or myocardium (25%) and maybe located more frequently in the left ventricle or right atrium ( 8 ). Clinical manifestations of cardiac lipomas depend on tumor size and location.…”

Section: Discussionmentioning

confidence: 99%

Cardiac lipoma

Ismail

Al-Khafaji

Mutyala

et al. 2015

Journal of Community Hospital Internal Medicine Perspectives

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Lipomas of the heart are encapsulated tumors that are composed primarily of mature fat cells. Cardiac lipomas can originate either from subendocardium (approximately 50%), subpericardium (25%), or from the myocardium (25%) and may be located more frequently in left ventricle or right atrium. We report a 74-year-old female who presented with dyspnea on exertion and was found to have 5×5 cm mass occupying most of the right atrium on a transesophageal echocardiogram.

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Lipoma of the heart

Cited by 26 publications

References 8 publications

A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis

A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis

Incidental finding of giant pericardial lipoma

Cardiac lipoma

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