Lipoperoxidative Damage on Lead Exposure in Rat Brain and its Implications on Membrane Bound Enzymes

Sandhir, Rajat; Julka, Deepinder; Gill, Kiran Dip

doi:10.1111/j.1600-0773.1994.tb01077.x

Cited by 186 publications

(96 citation statements)

References 26 publications

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“…Our previous studies (Ercal et al 1996;Gurer et al 1998Gurer et al , 1999a as well as the present one support the hypothesis indicated by several other groups (Ribarov and Bochev 1982;Ito et al 1985;Monterio et al 1985Monterio et al , 1991Lawton and Donaldson 1991;Sandhir et al 1994;Solliway et al 1996) that Fig. 2.…”

Section: Discussionsupporting

confidence: 92%

Antioxidant Effect of Taurine Against Lead-Induced Oxidative Stress

Gürer

Özgüneş

Saygın

et al. 2001

Arch. Environ. Contam. Toxicol.

139

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Abstract. Oxidative stress is proposed as a molecular mechanism in lead toxicity, which suggests that antioxidants might play a role in the treatment of lead poisoning. The present study was designed to investigate whether taurine has a beneficial effect both on Chinese hamster ovary (CHO) cells and on Fisher 344 (F344) rats following lead exposure. Therefore, oxidative stress parameters (glutathione, malondialdehyde levels, catalase, and glucose-6-phosphate dehydrogenase [G6PD] activities) of lead-exposed CHO cells and F344 rats were determined following taurine treatment. Taurine was found to be effective in (1) increasing glutathione levels that had been diminished by lead; (2) reducing malondialdehyde levels, an end-product of lipid peroxidation; (3) decreasing catalase and erythrocyte G6PD activity, which had been increased by lead exposure; and (4) improving cell survival of CHO cells. However, taurine had no effect on blood and tissue lead levels when 1.1 g/kg/day taurine was administered to F344 rats for 7 days, following 5 weeks of lead exposure (2,000 ppm lead acetate). As a result, taurine seems to be capable of fortifying cells against lead-induced oxidative attack without decreasing lead levels. Therefore, administration of taurine, accompanied by a chelating agent, might increase its effectiveness in the treatment of lead poisoning.

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Section: Discussionsupporting

confidence: 92%

Antioxidant Effect of Taurine Against Lead-Induced Oxidative Stress

Gürer

Özgüneş

Saygın

et al. 2001

Arch. Environ. Contam. Toxicol.

139

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“…In general, ROS are involved in impairing the polyunsaturated fatty acids of the membrane phospholipids of the cells causing defects of cellular functions (Halliwell and Gutteridge, 1985). Pb exposure was also related with tissue oxidative damage in chicks (Donaldson and Leeming, 1984) and rats (Sandhir et al, 1994).…”

Section: Leadmentioning

confidence: 99%

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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The documents on Metallothioneins (MTs) in aquatic creatures, especially focusing on their function as biomarkers in environmental monitoring programmes, are vast and increasing. There are, however, few papers to summary the physiological role of MTs in aquatic organisms especially on development. The multifaceted roles of MTs include involvement in homeostasis, protection against heavy metals and oxidant damages, and metabolic regulation, sequestration and/or redox control. In this paper, we have collected published information on MTs in aquatic organisms-pisces, amphibians, mammals, etc., and analyzed their function in these aquatic animals. MTs have four main functions in aquatic vertebrate. They are respectively bioaccumulation of toxic metals and detoxification, homeostatic regulation of metals, protection against oxidative stress and neuroprotective mechanism. MTs separate in different tissues and they have various distributions in different tissues of aquatic vertebrate, including liver, gills, kidney, testes, and brain. MTs can be induced by a variety of environmental and physiological factors, among which, heavy metals are the main kind of MTs inducers in aquatic vertebrate. Here we pay more attention on the essential metals copper (Cu) and zinc (Zn) and the non-essential metals cadmium (Cd), silver (Ag), lead (Pb), and mercury (Hg).

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“…Ratos tratados com chumbo mostraram diminuição dos níveis séricos de glutationa (Alexander et al, 1986), composto que poderia estar envolvido nos mecanismos de defesa contra as espécies reativas de oxigênio geradas pelo chumbo. Índices de correlação positiva entre TBARS e concentração sangüínea de chumbo foram obtidos no grupo controle (r=0,602) e no de atiradores indoor (r=0,432), corroborando resultados obtidos em ratos tratados com chumbo (Sandhir et al, 1993;Neal et al, 1998;Adonaylo e Oteiza, 1999;Gurer et al, 1999), em trabalhadores de minas de chumbo (Ye et al, 1999) e em indivíduos com concentrações sangüíneas de chumbo superiores a 35µg/dL (Jiun e Hsien, 1994). O chumbo inibe a biossíntese do heme, resultando num acúmulo de ALA, que, em pH fisiológico, autoxida-se, levando à formação de radical superóxido (O (Halliwell e Gutteridge, 2000).…”

Section: Resultsunclassified

Avaliação do estresse oxidativo e contaminação por chumbo em praticantes de tiro esportivo

Montano¹,

Soares²,

Salvador³

2003

Acta Sci. Health Sci.

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RESUMO. O chumbo, metal utilizado na fabricação de munições, pode depletar a glutationa e gerar espécies reativas de oxigênio capazes de desencadear reações de peroxidação lipídica. Neste trabalho, avaliou-se uma possível correlação entre chumbo e estresse oxidativo em praticantes de tiro esportivo nas modalidades ao ar livre, indoor e não-atiradores. A concentração de chumbo sangüínea foi determinada por absorção atômica, a peroxidação lipídica pela concentração dos produtos de reação com o ácido tiobarbitúrico (TBARS) e a capacidade antioxidante total foi avaliada utilizando-se o kit Total Antioxidant Status (RANDOX  ). Os resultados mostraram que 12,5% dos atiradores ao ar livre e 20,8% indoor apresentaram valores sangüíneos de chumbo acima dos considerados normais para grupos não-expostos. Os valores de TBARS mostraram-se significativamente maiores nos praticantes de tiro. A capacidade antioxidante total medida no soro dos indivíduos dos três grupos amostrados não se mostrou alterada.Palavras-chave: chumbo, peroxidação lipídica, praticantes de tiro. ABSTRACT. Oxidative stress evaluation and lead contamination in marksmen.Lead is a toxic metal used in munitions. Recent studies have shown indications of oxidative stress in mice treated with lead acetate. Our work had the goal of evaluating the possible correlation of lead and oxidative stress in human outdoor and indoor marksmen. The lead concentration was measured by atomic absorption. Oxidative stress was accessed through the reaction products with tiobarbituric acid (TBARS) and the total antioxidant capacity was appraised using Total Antioxidant Status (RANDOX  ). The results show that 12,5% of the outdoor and 20,8% of the indoor marksmen present lead values over what is considered normal in non-exposed groups. TBARS were significantly higher for marksmen than for the control group. No statistically significant differences in the total serum antioxidant capacity were observed in individuals tested.Key words: lead, lipid peroxidation, marksmen. IntroduçãoO chumbo é um metal não-essencial para o homem e altamente tóxico, mesmo em baixas concentrações (Roy e Rossmann, 1992; Larini, 1993; Kerper e Hinkle, 1997; Erdahl et al., 1999). É amplamente utilizado na fabricação de baterias, tubulações, tintas e munições (Fairfax, 1997) e seus efeitos tóxicos podem estar associados a exposição aguda a altas doses ou à exposição crônica a baixas concentrações desse elemento. Em vista disso, trabalhadores de muitas indústrias são regularmente monitorados quanto à exposição crônica a este metal.A contaminação por chumbo pode ocorrer tanto por inalação e ingestão quanto pela pele (Mayer e Wilson, 1998). Os praticantes de tiro esportivo estão sujeitos à contaminação por chumbo quando o esporte é praticado ao ar livre e também em ambiente fechado, tornando-se particularmente importante em stand indoor devido à deficiência de ventilação. Nas munições, o chumbo está presente na forma de estifinato de chumbo, que sofre volatilização no momento do disparo da arma, podendo ser ...

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Lipoperoxidative Damage on Lead Exposure in Rat Brain and its Implications on Membrane Bound Enzymes

Cited by 186 publications

References 26 publications

Antioxidant Effect of Taurine Against Lead-Induced Oxidative Stress

Antioxidant Effect of Taurine Against Lead-Induced Oxidative Stress

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Avaliação do estresse oxidativo e contaminação por chumbo em praticantes de tiro esportivo

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