Lipoprotein (a) Level Among Patients with Type 2 Diabetes Mellitus and Prediabetes in Comparison with Healthy Controls

Abdullah, Barhav Issa; Salih, Sherwan Ferman

doi:10.25271/sjuoz.2023.11.1.996

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Our current study showed that there was an increase in the levels of urea, creatinine, microalbuminuria, and a decrease in the glomerular filtration rate (GFR) in the diabetic groups compared to the control group 24 . Hyperinsulinemia indicates a strong positive association between the level of blood sugar with urea and creatinine.…”

Section: Discussionmentioning

confidence: 58%

التنبؤ المبكر بالاعتلال الكلوي لمرضى عراقين مصابين بالسكري النوع الثاني بدلالة تقييم بعض العوامل البيوكيمائية ذات الصلة

Ibrahim,

Ghudhaib,

Allawi

2024

Baghdad Sci.J

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Type 2 diabetes mellitus (T2DM) is a complex disease, which affects many organs besides the pancreas such as the kidney, liver, brain and eye. Due to hyperglycemia at long periods and uncontrolled on diabetes with presence of other risk factors, diabetes complications could occurr. Diabetes complications include microvascular and macrovascular complications that target the kidneys. The aim of this study is to predict early fibrosis of the renal glomeruli and tubules by evaluating the levels of angiotensin-converting enzyme -2(ACE-2), connective tissue growth factor (CTGF) and some relevant biochemical factors in patients with type 2 diabetes. The study included 120 male and female ranging in age 30-65 years old, they were subdivided into three groups according to ACR criteria include normoalbuminuria, microalbuminuria, macroalbuminuria (30 patients for each group) and 30 healthy people served as the control group, who visited Baghdad Teaching Hospital / Medical City and Al-Yarmouk Teaching Hospital, at the period between December 2021 and May 2022. Lipid profile, FBS, urea levels were estimated using calorimetric techniques. ACE-2, CTGF levels were determined using the ELISA technique. The results showed significant differences between groups of patients and control group for (CTGF), (ACE-2) levels were found to be significant increase in patients’ groups than healthy control. Also, the results showed that both fasting blood sugar (FBS) and hemoglobin A1c (HbA1C) were significantly increased in patients’ groups compared to healthy group. Furthermore, estimated glomerular filtration rate (eGFR) revealed high significant differences among all the studied groups, as well as albumin to creatinine ratio (ACR) which showed high significant differences among the three patients’ groups which represents the basic criteria for classification of patient groups. On the basis of the obtained results in this study, it can be concluded that each of ACE-2 and CTGF markers can be applied as early reliable prognosticated factors for detection disease progression.

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Section: Discussionmentioning

confidence: 58%

التنبؤ المبكر بالاعتلال الكلوي لمرضى عراقين مصابين بالسكري النوع الثاني بدلالة تقييم بعض العوامل البيوكيمائية ذات الصلة

Ibrahim,

Ghudhaib,

Allawi

2024

Baghdad Sci.J

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“…(HOMA-IR) is a widely used method for measuring insulin resistance. It was derived from the following formula: HOMA-IR = [fasting glucose] (mg/dl) × [fasting insulin] (μU/ml)/405 (Abdullah & Salih, 2023). .…”

Section: Materials and Methodologymentioning

confidence: 99%

Evaluation of Thyroid Function Markers in Type 2 Diabetic Patients in Relation to Insulin Resistance

Othman,

Kakey

2023

SJUOZ

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Diabetes mellitus (DM) and thyroid disorders are both caused by endocrine abnormalities, and both have been shown to have a reciprocal influence and frequently coexist. Hence, the current study aims to detect the thyroid functions markers among patients with Type 2 diabetes (T2DM). In this research study, 90 enrolled participants aged 40 to 60 years were taken as samples for the study. There were 66 with T2DM and 24 who were non diabetic healthy individual. All individuals were investigated in terms of age, gender, diabetes duration, glycemic control (HbA1c), fasting blood glucose (FBG), diabetic complications, Body mass index (BMI), waist circumference (WC), and family history of DM. Samples were to assess serum thyroid hormones (TSH, FT3 and FT4), HbA1c, FBG, and insulin levels. The study's findings showed higher glucose incidence, hyperinsulinemia and higher insulin resistance (IR) in diabetic patients. Additionally, it has been noted that T2DM patients have low TSH concentrations and elevated blood concentrations of FT4 and FT3 than controls. Moreover, there was a highly significant correlation between serum FT4 and FT3 with values of FBG, insulin and IR. Also, a significant association between WC with insulin and Homa – Ir was noted. In conclusion, the diabetic patients showed significant relations with thyroid functions status.

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“…Lipoprotein(a) (Lp(a)) is a variant of LDL and considered as an independent risk factor for CVD, as a study demonstrated that cardiovascular disorder risk increases proportionally with increasing Lp(a) levels [ 4 ]. Moreover, Lp(a) is highly associated with impaired glucose metabolism [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Lipoprotein and Apolipoprotein Ratios With Glycemic Levels in Individuals With Prediabetes: A Case-Control Study

Salih

2024

Cureus

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Background: Prediabetes is defined as a hyperglycemic state between normal glucose metabolism and diabetes mellitus. It is also recognized as a predisposing factor for cardiovascular disease. Apolipoprotein is a constituent of lipoproteins, and its ratio levels (ApoB/ApoA1 ratio) are considered an independent risk factor for cardiovascular diseases. This study aimed to evaluate the apolipoprotein ratio (ApoB/ApoA1 ratio) and lipoprotein ratio (low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio) in prediabetes in relation to glycemic levels and establish the association between apolipoprotein and lipoprotein ratios in prediabetic individuals and their glycemic levels. Methodology: A case-control study was conducted among 150 participants, 75 with prediabetes and 75 apparently healthy individuals (with no prediabetes or diabetes), from January 1, 2023 to December 30, 2023. The parameters involved are fasting serum glucose, insulin, blood HbA1c%, HDL-C, LDL-C, apolipoprotein A, apolipoprotein B, and lipoprotein(a) (Lp(a)), measured using different principles. Results: Prediabetes was more predominant in males (58.7%), particularly those aged over 40 years (74.7%). The mean Lp(a) (46.18±11.66 mg/dl), LDL-C/HDL-C ratio (1.74±0.96), and ApoB/ApoA ratio (1.10±0.62) were significantly higher among prediabetic individuals. Moreover, these ratios were insignificantly higher in prediabetic individuals with HbA1c level (5.8-6.4%) and fasting glucose level (100-125 mg/dl) than those with lower levels. Conclusions: Prediabetic individuals exhibited a notably elevated average level of Lp(a), as well as increased mean ApoB/ApoA1 ratio and mean LDL-C/HDL-C ratio compared to individuals who were apparently healthy.

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Lipoprotein (a) Level Among Patients with Type 2 Diabetes Mellitus and Prediabetes in Comparison with Healthy Controls

Cited by 4 publications

References 37 publications

التنبؤ المبكر بالاعتلال الكلوي لمرضى عراقين مصابين بالسكري النوع الثاني بدلالة تقييم بعض العوامل البيوكيمائية ذات الصلة

التنبؤ المبكر بالاعتلال الكلوي لمرضى عراقين مصابين بالسكري النوع الثاني بدلالة تقييم بعض العوامل البيوكيمائية ذات الصلة

Evaluation of Thyroid Function Markers in Type 2 Diabetic Patients in Relation to Insulin Resistance

Association of Lipoprotein and Apolipoprotein Ratios With Glycemic Levels in Individuals With Prediabetes: A Case-Control Study

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