Atherosclerosis

1999

DOI: 10.1016/s0021-9150(98)00298-6

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Lipoprotein (a) level in the population in Taiwan: relationship to sociodemographic and atherosclerotic risk factors

Kuo–Liong Chien

¹

,

²

,

Fung‐Chang Sung

³

et al.

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Measurement Of Biochemical Markers1

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Cited by 33 publications

(41 citation statements)

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“…Positive correlations of Lp(a) with apo B and LDL cholesterol in Roma and Caucasian children, respectively, corresponded with previous data, including our own, showing higher Lp(a) levels in subjects with hypercholesterolemia [19,24,28]. The fact that Lp(a) and LDL have a common synthetic pathway is likely to be an explanation for the positive association of Lp(a) and LDL cholesterol.…”

Section: Discussionsupporting

confidence: 90%

“…In contrast, an early shortlived rise, a comparable decline, and a subsequent rise during puberty (only in Caucasians) was found in females. Observed no significant gender difference in Lp(a) levels is consistent with findings reported by several studies [23][24][25], but not by others demonstrating significantly higher Lp(a) values in females [19,22,26]. Further research is required to link the evidence concerning the effect of sex hormones on the Lp(a) metabolism in prepubertal and pubertal children.…”

Section: Discussionsupporting

confidence: 89%

“…Apo B and LDL cholesterol, sometimes triglycerides, insulin resistance, and smoking, but not daily income, are often listed as independent variables in predicting Lp(a) concentration [19,20,24]. It is possible that the relationship between Lp(a) and daily income, observed in our study, may be a random cohort-effect phenomenon.…”

Section: Discussionmentioning

confidence: 74%

“…Socioeconomic status is a major determinant of health, lifestyle and health-related behaviour, sufficient quantities of food and quality of nutrition, and opportunities for education [11]. In one from a few Asian studies, the socioeconomic status did not have a consistent influence on the Lp(a) levels in evenly earner stratificated ethnic Chinese Taiwan population [24].…”

Section: Discussionmentioning

confidence: 99%

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Lipoprotein(a) in Children of Asian Indian Descendants and Their Caucasian Neighbors: The Slovak Lipid Community Study

¹

,

²

2012

Ind J Clin Biochem

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To elucidate a higher rate of premature cardiovascular disease (CVD) in Asian Indian descendants (Roma) in Slovakia, we investigated frequency distribution, correlates and relationship of lipoprotein(a) [Lp(a)] to family CVD risk factors in Roma children and their Caucasian neighbors. The study sample consisted of 607 healthy children aged 7-18 years (55% Roma, 48% male) as part of the biracial (Roma-Caucasian) Slovak Lipid Community Study. Overall, frequency distribution data of Lp(a) were highly skewed to low concentrations, with markedly higher Lp(a) levels in Roma than in Caucasian children (median and range, mg/dL: 14.5; 0-159.2 vs 6.2; 0-112.3, P \ 0.001), regardless of age and gender. Lp(a) was positively correlated with apo B (0.159, P = 0.004) in Roma, and LDL cholesterol (0.170, P = 0.005) in Caucasian children. In addition, daily income of the family was negatively related with Lp(a) in Roma (-0.134, P = 0.036) while positively in Caucasians (0.136, P = 0.047). For both race groups, no significant association was found between Lp(a) and age, body mass index, mean arterial pressure, smoking, and physical activity. Also, no significant relationships were examined between serum Lp(a) levels [30 mg/dL in children and family CVD risk factors, except for diabetes mellitus in parents of Caucasian origin (OR 4.46;. In a multivariate analysis, daily income, LDL cholesterol or apo B explained *7% of the variance of Lp(a). This study suggests a significantly higher serum Lp(a) levels in Roma than in Caucasian children and a small effect, in general, of relevant CVD risk factors on the variation of Lp(a) levels in childhood.

“…Positive correlations of Lp(a) with apo B and LDL cholesterol in Roma and Caucasian children, respectively, corresponded with previous data, including our own, showing higher Lp(a) levels in subjects with hypercholesterolemia [19,24,28]. The fact that Lp(a) and LDL have a common synthetic pathway is likely to be an explanation for the positive association of Lp(a) and LDL cholesterol.…”

Section: Discussionsupporting

confidence: 90%

“…In contrast, an early shortlived rise, a comparable decline, and a subsequent rise during puberty (only in Caucasians) was found in females. Observed no significant gender difference in Lp(a) levels is consistent with findings reported by several studies [23][24][25], but not by others demonstrating significantly higher Lp(a) values in females [19,22,26]. Further research is required to link the evidence concerning the effect of sex hormones on the Lp(a) metabolism in prepubertal and pubertal children.…”

Section: Discussionsupporting

confidence: 89%

“…Apo B and LDL cholesterol, sometimes triglycerides, insulin resistance, and smoking, but not daily income, are often listed as independent variables in predicting Lp(a) concentration [19,20,24]. It is possible that the relationship between Lp(a) and daily income, observed in our study, may be a random cohort-effect phenomenon.…”

Section: Discussionmentioning

confidence: 74%

“…Socioeconomic status is a major determinant of health, lifestyle and health-related behaviour, sufficient quantities of food and quality of nutrition, and opportunities for education [11]. In one from a few Asian studies, the socioeconomic status did not have a consistent influence on the Lp(a) levels in evenly earner stratificated ethnic Chinese Taiwan population [24].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Lipoprotein(a) in Children of Asian Indian Descendants and Their Caucasian Neighbors: The Slovak Lipid Community Study

¹

,

²

2012

Ind J Clin Biochem

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To elucidate a higher rate of premature cardiovascular disease (CVD) in Asian Indian descendants (Roma) in Slovakia, we investigated frequency distribution, correlates and relationship of lipoprotein(a) [Lp(a)] to family CVD risk factors in Roma children and their Caucasian neighbors. The study sample consisted of 607 healthy children aged 7-18 years (55% Roma, 48% male) as part of the biracial (Roma-Caucasian) Slovak Lipid Community Study. Overall, frequency distribution data of Lp(a) were highly skewed to low concentrations, with markedly higher Lp(a) levels in Roma than in Caucasian children (median and range, mg/dL: 14.5; 0-159.2 vs 6.2; 0-112.3, P \ 0.001), regardless of age and gender. Lp(a) was positively correlated with apo B (0.159, P = 0.004) in Roma, and LDL cholesterol (0.170, P = 0.005) in Caucasian children. In addition, daily income of the family was negatively related with Lp(a) in Roma (-0.134, P = 0.036) while positively in Caucasians (0.136, P = 0.047). For both race groups, no significant association was found between Lp(a) and age, body mass index, mean arterial pressure, smoking, and physical activity. Also, no significant relationships were examined between serum Lp(a) levels [30 mg/dL in children and family CVD risk factors, except for diabetes mellitus in parents of Caucasian origin (OR 4.46;. In a multivariate analysis, daily income, LDL cholesterol or apo B explained *7% of the variance of Lp(a). This study suggests a significantly higher serum Lp(a) levels in Roma than in Caucasian children and a small effect, in general, of relevant CVD risk factors on the variation of Lp(a) levels in childhood.

“…[20][21] Briefly, all venous blood samples drawn after a 12-h overnight fast were immediately refrigerated and transported within 6 h to the National Taiwan University Hospital. Serum samples were then stored at -70 1C before batch assay for levels of total cholesterol, triglycerides and high-density lipoprotein cholesterol.…”

Section: Measurement Of Biochemical Markersmentioning

confidence: 99%

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

¹

,

²

,

³

et al. 2010

J Hum Hypertens

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Prediction model for hypertension risk in Chinese is still lacking. We aimed to propose prediction models for new-onset hypertension for ethnic Chinese based on a prospective cohort design on community, which recruited 2506 individuals (50.8% women) who were not hypertensive at the baseline . Total 1029 cases of new-onset hypertension developed during a median of 6.15 (interquartile range, 4.04-9.02) years of followup. In the clinical model, gender (2 points), age (8 points), body mass index (10 points), systolic blood pressure (19 points) and diastolic blood pressure (7 points) were assigned. The biochemical measures, including white blood count (3 points), fasting glucose (1 point), uric acid (3 points), additional to above clinical variables, were constructed. The areas under the receiver operative characteristic curves (AUCs) were 0.732 (95% confidence interval (CI), 0.712-0.752) for the point-based clinical model and 0.735 (95% CI, 0.715-0.755) for the point-based biochemical model. The coefficient-based models had a good performance (AUC, 0.737-0.741). The point-based clinical model had a similar net reclassification improvement as the coefficient-based clinical model (P ¼ 0.30), and had a higher improvement than the point-based biochemical model (P ¼ 0.015). We concluded that the point-based clinical model could be considered as the first step to identify high-risk populations for hypertension among Chinese.

Oxidized lipoprotein(a) and cardio-ankle vascular index (CAVI) in hypertensive subjects

¹

,

³

et al. 2012

Heart Vessels

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While oxidized lipoprotein(a) (oxLp(a)) has been indicated to be involved in atherogenesis more than native lipoprotein(a) (Lp(a)), there is still a need to elucidate the associations among oxLp(a), hypertension, and atherosclerosis. The cardio-ankle vascular index (CAVI) is a recently developed index used to assess arterial stiffness that is independent of blood pressure components. The present study investigated the correlation between oxLp(a) and the CAVI among hypertensive subjects. Clinical data, including general atherosclerotic risk factors, in addition to Lp(a), oxLp(a), and the CAVI, were collected from 72 non-smoking, asymptomatic, and untreated female subjects (mean age: 64.3 years). Correlations between the CAVI and Lp(a) or oxLp(a) were examined in a hypertensive group (n = 34) and a non-hypertensive control group (n = 38). There was a significant and positive correlation between the CAVI and subject age in the control group, while there was a significant and positive correlation between the CAVI and subject age, systolic blood pressure, and oxLp(a) (r = 0.38, p < 0.05) in the hypertensive group. A stepwise multiple linear regression analysis identified the oxLp(a) to be correlated independently, significantly, and positively with the CAVI (β = 0.30, p < 0.05) in the hypertensive group, while this correlation was not significant in the control group. These findings suggest that the oxidative modification of Lp(a) may be associated with arterial stiffness in hypertensive, but not non-hypertensive, female subjects.

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