Lipoprotein Changes after Burn Injury in Man

Coombes, E J; Shakespeare, P.G.; Batstone, G.F.

doi:10.1097/00005373-198011000-00012

Cited by 76 publications

(35 citation statements)

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“…This study confirms other reports of reduced PL and CE levels following burn injury (5,(21)(22)(23)(24)(25) and expands existing knowledge by demonstrating that n-6, particularly 20:4n-6, and n-3 fatty acids are reduced in the early post-burn period in plasma and erythrocytes. Reduced amounts of essential fatty acids in plasma suggest decreased availability from the diet or an increase in their utilization by the tissues.…”

Section: Discussionsupporting

confidence: 91%

Fatty acid content of plasma lipids and erythrocyte phospholipids are altered following burn injury

Pratt

Tredget

Clandinin

et al. 2001

Lipids

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The objective of this study was to examine compositional and quantitative changes in fatty acids of plasma components and red blood cell phospholipids (PL) immediately following and during recovery from burn injury. Subjects (n = 10) with >10% total body surface area burn had blood drawn at specific timepoints (0 to >50 d) following burn injury. Fatty acid composition of red blood cell PL and plasma PL, cholesteryl esters (CE), and triglycerides was determined using gas-liquid chromatography after separating each fraction from extracted lipids by thin-layer chromatography. Total plasma PL and CE in burn patients were lower than in healthy control subjects with reduced 20:4n-6, n-6, and n-3 fatty acids and higher levels of monounsaturated and saturated fatty acids early after burn. CE levels remained half that of healthy control values up to 50 d post-burn. Red blood cell PL had decreased 20:4n-6 content and profiles similar to that of an essential fatty acid deficiency early after burn. These results suggest an impairment in lipoprotein and polyunsaturated fatty acid metabolism in the early post-burn period. Lower levels of 20:4n-6 and n-3 fatty acids in every plasma fraction suggest increased use of these fatty acids for wound healing and immune function following burn injury. Further work is needed to determine the ability of burn patients to utilize essential fatty acids in order to design nutritional intervention that promotes wound healing and immunological functions consistent with recovery in these patients.

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Section: Discussionsupporting

confidence: 91%

Fatty acid content of plasma lipids and erythrocyte phospholipids are altered following burn injury

Pratt

Tredget

Clandinin

et al. 2001

Lipids

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“…It was quite possible that lipoproteins including Lp (a) were similarly changed due to denaturation. 2) In the immediate period following CPB all lipid, lipoprotein and apolipoprotein concentrations except Lp (a) remained significantly lower than the preoperative concentrations, in close agreement with results previously reported for major surgery, 2,6) infections, 2,7) burn injuries, 2,8) and myocardial infarction. 2,9) In that respect, CPB did not differ from major surgery and the effect of extracorporeal circulation and hemodilution on lipid metabolism several hours after the operation was minimal.The striking result of their study was the rise in Lp (a) levels at the initial period and throughout CPB.…”

supporting

confidence: 89%

“…The lipid and lipoprotein values, except Lp (a), remained significantly lower than the preoperative values in the early postoperative period, in close agreement with the results previously reported for major surgery and other conditions. 2,[7][8][9] Paradoxically, Lp (a) levels increased at onset, doubled (or 60% increase) during CPB and remained elevated postoperatively in both of these groups. At the onset and during CPB a rapid and significant rise in Lp (a) was found to be statistically significant for the two groups (p<0.001 in 80 patients).…”

Section: Discussionmentioning

confidence: 99%

Effect of Cardiopulmonary Bypass on Plasma Levels of Lipoprotein (a) in Hypercholesterolemic Patients.

et al. 2001

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SUMMARYIncrements of lipoprotein (a) (Lp (a)) concentration during cardiopulmonary bypass (CPB) have not been justified in the literature yet. We have investigated whether Lp (a) levels remain constant or increase during CPB and if high plasma levels of low density lipoprotein (LDL; containing apolipoprotein (apo) B) in hypercholesterolemic patients affect the assembly of Lp (a) (containing apoB: Apo (a)).In this study, the change in plasma lipid and lipoprotein levels of 40 patients with hypercholesterolemia and 40 patients who have normal cholesterol values were determined and compared during CPB, and in the postoperative early stage. In our study, lipid and lipoproteins, except Lp (a), showed a falling trend and paradoxically, Lp (a) statistically showed a significant rising trend, like the acute phase reactant in two groups (p=0.011 for LDL, p=0.016 for high density lipoprotein (HDL) and p<0.001 for the others, in 80 patients). Concentrations of Lp (a) in plasma increased more sharply in the hypercholesterolemic group than the normocholesterolemic group during CPB. This difference was significant at the 60 th minute of cardiopulmonary bypass with a nonparametric test (p<0.05 Mann-Whitney U test). High density lipoprotein values showed more decline in the hypercholesterolemic group patients than in the normocholesterolemic group patients (p<0.05). In conclusion, lipoprotein (a) levels increased more pronounced in patients with hypercholesterolemia during CPB. On the other hand, high LDL levels in hypercholesterolemic patients accelareted Lp (a) formation in the acute phase. (Jpn Heart J 2001; 42: 563-574) Key words: Lipoprotein (a) (Lp(a)), Low density lipoprotein (LDL), Cardiopulmonary bypass (CPB), Acute phase reactant, Hypercholesterolemia, Lipids and lipoproteins, Coronary artery bypass grafting (CABG) PREVIOUS studies have shown a decrease in plasma concentrations of total cholesterol, HDL and LDL-cholesterol following major surgical operations without using extracorporeal circulation and hemodilution.1-4) Decreases in apoAI and apoB have also been reported with concomitant increases in acute phase proteins such as oromucoid, α-1 antitrypsin, ceruloplasmin and C-reactive protein, following surgical procedures. 2,5) On the other hand, in the study of Maeda, et al Lp From

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“…2, 5). Others have reported that whereas total phospholipid levels decline somewhat in critically ill or infected patients (10,(36)(37)(38), they do not decline as precipitously as do total cholesterol levels, which are lost from both HDL and LDL fractions. In keeping with our observations, these studies found that the loss of HDL phospholipids accounted for most of the decline in total phospholipids, whereas little decrease occurred in LDL and no phospholipids were lost from VLDL.…”

Section: Discussionmentioning

confidence: 99%

Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins

Kitchens

Thompson

Munford

et al. 2003

Journal of Lipid Research

113

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Lipoprotein Changes after Burn Injury in Man

Cited by 76 publications

References 0 publications

Fatty acid content of plasma lipids and erythrocyte phospholipids are altered following burn injury

Fatty acid content of plasma lipids and erythrocyte phospholipids are altered following burn injury

Effect of Cardiopulmonary Bypass on Plasma Levels of Lipoprotein (a) in Hypercholesterolemic Patients.

Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins

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