Lipoprotein detection: Hybrid deep classification model with improved feature set

Abstract

Patients with chronic liver diseases typically experience lipid profile problems, and mortality from cirrhosis complicated by portal vein thrombosis (PVT) is very significant. A lipoprotein (Lp) is a bio-chemical assemblage with the main job of moving fat molecules in water that are hydrophobic. Lipoproteins are present in all eubacterial walls. Lipoproteins are of tremendous interest in the study of spirochaetes’ pathogenic mechanisms. Since spirochaete lipobox sequences are more malleable than other bacteria, it’s proven difficult to apply current prediction methods to new sequence data. The major goal is to present a Lipoprotein detection model in which correlation features, enhanced log energy entropy, raw features, and semantic similarity features are extracted. These extracted characteristics are put through a hybrid model that combines a Gated Recurrent Unit (GRU) and a Long Short-Term Memory (LSTM). Then, the outputs of GRU and LSTM are averaged to obtain the output. Here, GRU weights are optimized via the Selfish combined Henry Gas Solubility Optimization with cubic map initialization (SHGSO) model.

Advances in Henry Gas Solubility Optimization: A Physics-Inspired Metaheuristic Algorithm With Its Variants and Applications

“…Kathavate et al [121] introduced a novel model for detecting lipoproteins, addressing lipid profile challenges in patients with chronic liver diseases, particularly those complicated by portal vein thrombosis (PVT). The proposed model employs a hybrid approach, integrating semantic similarity features, raw features, enhanced log energy entropy, and correlation features.…”