Liposarcoma of soft tissue: MRI findings with pathologic correlation

Abstract

All tumors showed well-defined and mostly lobulated margins. The well-differentiated liposarcomas were composed mainly of fat with septations or nodules, were hyperintense on T2-weighted images, and demonstrated faint enhancement or no enhancement following intravenous contrast. Myxoid liposarcomas were homogeneous or mildly heterogeneous and a pseudocapsule was present in one case. Pleomorphic types showed a markedly heterogeneous internal structure. Both myxoid and pleomorphic lesions-showed moderate or marked heterogeneous enhancement after contrast administration. Well-differentiated liposarcomas may be differentiated from other types of the tumor by their largely lipomatous appearance. The malignancy grade increases in parallel with tumor heterogeneity and contrast enhancement.

Chemotherapy Influences the Pseudocapsule Composition in Soft Tissue Sarcomas

“…Because viable tumor cells can be found extending beyond the pseudocapsule, resection achieving a marginal surgical margin should be supplemented with radiation treatment to decrease local recurrence [2,6,8,15]. Since the original description of the STS pseudocapsule in a rat model, there have been several histological descriptions of the pseudocapsule in treated or untreated human STS and its response to adjuvant chemotherapy [9][10][11][12].…”

Orthopaedic Case of the Month: A Painless Right Knee Mass in a 55-year-old Woman

“…A well-differentiated liposarcoma is a low-grade sarcoma affecting predominantly middle-aged patients. It often present as a painless, slow-growing mass which may by locally aggressive but it rarely metastasizes [1,8]. The primary intraarticular liposarcoma is rare [14].…”

“…The primary intraarticular liposarcoma is rare [14]. The characteristic features of a well-differentiated liposarcoma on MR images are large lesion size, presence of thick septa, and presence of nonlipomatous soft tissue components with decreased percentage of fat composition [1,8]. However, contrary to a well-differentiated liposarcoma, an intraarticular lipoma manifests as a purely lipomatous lesion.…”

Surgical resection of a well-differentiated inflammatory liposarcoma of the middle mediastinum: a case report

“…The imaging findings of liposarcoma are quite different; however, they tend to show a clear border and lobular images on MRI. The contrast effect varies depending on the tumor's degree of differentiation; poorly differentiated tissue type tumors with higher malignancy tend to show greater contrast (5). Likewise, it is reported that liposarcomas with lower degrees of differentiation tend to show more nonuniform and higher CT values (6).…”