2019
DOI: 10.3390/molecules24050846
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Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus

Abstract: Curcumin (CC) is known to have anti-inflammatory and anti-oxidative properties and has already been tested for its efficiency in different diseases including diabetes mellitus (DM). New formulations and route administration were designed to obtain products with higher bioavailability. Our study aimed to test the effect of intraperitoneal (i.p.) administration of liposomal curcumin (lCC) as pre-treatment in streptozotocin(STZ)-induced DM in rats on oxidative stress, liver, and pancreatic functional parameters. … Show more

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Cited by 48 publications
(48 citation statements)
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“…This will cause increased release of cardiac marker enzymes into the bloodstream, alternated ischemic electrocardiograph changes, accumulated lipid peroxides, and damaged cardiac function (6,7). Apart from oxidative stress, inflammation also plays an important role in the pathophysiology of AMI (8,9,10). The pathophysiological and morphologic alterations in the heart tissues of this drug-induced AMI experimental model are comparable with those taking place in human myocardial infarction (11,12).…”
Section: Introductionmentioning
confidence: 77%
“…This will cause increased release of cardiac marker enzymes into the bloodstream, alternated ischemic electrocardiograph changes, accumulated lipid peroxides, and damaged cardiac function (6,7). Apart from oxidative stress, inflammation also plays an important role in the pathophysiology of AMI (8,9,10). The pathophysiological and morphologic alterations in the heart tissues of this drug-induced AMI experimental model are comparable with those taking place in human myocardial infarction (11,12).…”
Section: Introductionmentioning
confidence: 77%
“…During the induction of diabetes, rats in the control group (n = 8) were intraperitoneally injected with a single dose of citric buffer solution (pH = 3.5), and rats in the STZ‐induced DM group (n = 32) were intraperitoneally injected with a single dose of STZ (15 mg/kg) freshly prepared in citric buffer solution (pH = 3.5). After 2 days of STZ injection, the serum glucose level of DM rats was monitored until the fasting serum glucose level was more than 20 mg/dL, and this was considered an STZ‐induced diabetic model . On the 36th day, control rats were treated with 1 mL phosphate‐buffered saline (PBS) per day for 10 days, and STZ‐induced DM rats were divided into 4 groups (n = 8 in each group).…”
Section: Methodsmentioning
confidence: 99%
“…After 2 days of STZ injection, the serum glucose level of DM rats was monitored until the fasting serum glucose level was more than 20 mg/dL, and this was considered an STZ-induced diabetic model. 22 On the 36th day, control rats were treated with 1 mL phosphate-buffered saline (PBS) per day for 10 days, and STZ-induced DM rats were divided into 4 groups (n = 8 in each group). The STZ-induced DM group rats were treated with 1 mL PBS per day for 10 days.…”
mentioning
confidence: 99%
“…The following doses were used: STZ-60 mg/100 g body weight (b.w.) [40]; EGCG in saline solution or in liposomal form were freshly prepared and were administrated i.p. in a dose of 2.5 mg/100 g b.w./day as pretreatment, two consecutive days before STZ administration [41].…”
Section: Experimental Modelmentioning
confidence: 99%