Liposomal Recombinant Human Superoxide Dismutase for the Treatment of Peyronie's Disease: A Randomized Placebo-Controlled Double-Blind Prospective Clinical Study

Riedl, Claus R.; Sternig, Peter; Gallé, G.; Langmann, Florian; Vcelar, Brigitta; Vorauer, Karola; Wagner, Alexandra; Katinger, Hermann; Pflüger, Heinz

doi:10.1016/j.eururo.2005.04.011

Cited by 60 publications

(40 citation statements)

References 21 publications

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“…A second RCT with human recombinant superoxide dismutase using a crossover design suggests some benefit, including pain relief. 45 The very short (12 week) observation period and small sample size (39 patients) limited this study's power to detect significant differences.…”

Section: Iontophoresismentioning

confidence: 93%

Peyronie's disease: a critical appraisal of current diagnosis and treatment

2008

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Peyronie's disease is a fibrotic disorder of the tunica albuginea of the penis resulting in varying degrees of penile curvature and sexual dysfunction. Diagnosis of the disorder is made by detailed sexual history and focused physical examination. A wide range of medical treatments has been employed to treat the disorder. Verapamil treatment administered by intraplaque injection is supported by generally consistent randomized controlled trials (RCT). Some RCT evidence exists to support the use of colchicine, potaba, L-carnitine and liposomal superoxide dismutase. Future studies of medical efficacy should focus on improving RCT design, implementation and results reporting to improve the quality of evidence generated by each study. The surgical treatment of Peyronie's disease is a viable and recommended alternative for men with compromised sexual function due to severe curvature or lesions causing penile instability. The choice of corrective procedure should be tailored to each patient after a detailed evaluation of disease severity and sexual function.

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Section: Iontophoresismentioning

confidence: 93%

Peyronie's disease: a critical appraisal of current diagnosis and treatment

2008

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“…L'étude est randomisée, en double insu, et les résultats montrent une très bonne efficacité sur la douleur (p = 0,017) et il n'y a plus de progression de la maladie dans le groupe traité [33].…”

Section: Gel à Base De Liposomes Superoxyde Dismutaseunclassified

Maladie de La Peyronie: connaissances validées et hypothèses en physiopathologie, épidémiologie, diagnostic et thérapeutique

et al. 2007

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Objet : La maladie de La Peyronie est décrite depuis plus de deux cents ans, mais elle demeure encore mal comprise. Cela explique le foisonnement d'hypothèses étiopathogéniques, même si aujourd'hui un certain consensus émerge.Mé thodes : Les grandes études reconnues et les conférences sur le sujet ont servi de base pour décrire la maladie de La Peyronie. Une revue systématique et presque exhaustive de la littérature depuis 2004 a été réalisée et a permis, avec l'expérience du service, de dégager les tendances actuelles.Résultats : Sur le plan étiopathogénique, l'hypothèse des microtraumatismes reste d'actualité mais n'est pas suffisante et les hypothèses auto-immune, génétique et vasculaire semblent actuellement valables. Il n'y a pas d'examens complémentaires nécessaires en pratique courante. Les traitements médicaux sont très nombreux et ont surtout fait la preuve de leur efficacité sur la douleur. On retiendra la vitamine E, la colchicine ainsi que les injections intraplaques de corticoïdes ou de vérapamil. Des traitements prometteurs par inhibiteurs de la phosphodiestérase de type 5 ou par injection d'interféron B doivent être validés. Les traitements chirurgicaux de correction de la courbure et des troubles de l'érection ne seront proposés que si la courbure est stabilisée depuis six mois. La qualité des érections, la taille de la verge, l'importance de la courbure et les souhaits du patient seront les éléments permettant de prendre la bonne décision thérapeutique. La correction de la courbure par la technique de Nesbit reste la technique de référence. En cas de plaque très importante et de troubles de l'érection, la section de la plaque avec greffe veineuse et prothèse gonflable est actuellement la meilleure technique. On citera la technique de Leriche, la mise en place d'implants souples et la lithotritie extra-corporelle comme possibles techniques d'avenir. Mots clés : La Peyronie -Chirurgie -Courbure -VergeDouleurPeyronie's disease: evidence-based knowledge and hypotheses in its pathophysiology, epidemiology, diagnosis and treatment Abstract: Subject: Although still poorly understood, La Peyronie's disease has been described for two hundred years. This lack of solid knowledge explains the existence of so many etiopathogenic hypotheses, despite the current emerging consensus.Method: We performed an exhaustive review of the major studies and conference reports on La Peyronie's disease since 2004 to determine present thinking on this condition.Results: The microtrauma hypothesis remains valid today but is not comprehensive enough to fully explain aetiology; explanations touching on autoimmunity, genetics and the vascular system are necessary to better understand the disease. Clinical examination suffices for establishing diagnosis. Medical treatment has mostly succeeded in managing pain. Vitamin E, colchicine, steroid and intraplaque verapamil injections are now accepted treatments. Further studies are needed to determine the efficacy of treatment with phosphodiesterase type 5 or beta interferon intraplaque...

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“…The level was lowest in subjects of category III tuberculosis. [14,[25][26][27][28] The toxic radicals produced by activated phagocytes during reaction cause maximal damage to membrane because they are active in a lipid phase. Lipid peroxide is obviously more polar than anything that should be present in the hydrophobic interior of biological membrane.…”

Section: Tuberculosis Lipid Peroxidation Tissue Injury Dna Damage mentioning

confidence: 99%

“…[14] Superoxide dismutase, and catalase constitute a mutually supportive team of defense against ROS. [23][24][25][26][27][28][29] Superoxide dismutase is a metalloprotein and is the first enzyme involved in the anti-oxidant defense by lowering the steady-state level of O 2 -. The insertion of superoxide dismutase genes into an individual's cells and tissues to treat disease.…”

Section: Tuberculosis Lipid Peroxidation Tissue Injury Dna Damage mentioning

confidence: 99%

“…Superoxide dismutase, by scavenging of free oxygen radicals, might interrupt inflammatory cascades and thereby limit further disease progression. [5] Manganese superoxide dismutase gene therapy could be applied in combination with other therapies, as chemotherapy a dual therapy achieving synergetic action for rapid breakdown of superoxide anions is needed to minimize overall tissue damage. Extracellular superoxide dismutase gene therapy, anti-inflammatory and anti-proliferative genes were found to be effective in decreasing neointimal formation.…”

Section: Introductionmentioning

confidence: 99%

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