Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons

Xu, Linqiang; Yu, Hua; Yin, Shaoping; Zhang, Ruixia; Zhou, Yudan; Li, Juan

doi:10.1007/s11051-015-3214-z

Cited by 22 publications

(17 citation statements)

References 51 publications

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“…Compound K-loaded liposomes modified with D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) (GCKT-liposomes) have enhanced solubility and show significant antitumor activity [ 139 ]. Among the three formulations of Rh2-loaded liposomes, i.e., Rh2-loaded normal liposome, Rh2-loaded cationic liposome, and Rh2-loaded methoxy poly(ethylene glycol)-polylactide (mPEG-PLA) liposome, the latter might be promising way to enhance the therapeutic index of anticancer agents [ 140 ]. Moreover, a liposomal formulation of Rg3 might improve anticancer activity [ 141 ].…”

Section: Prospects For Delivery and Clinical Study Of Ginseng Componementioning

confidence: 99%

Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study

et al. 2018

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Cognitive impairment is a state that affects thinking, communication, understanding, and memory, and is very common in various neurological disorders. Among many factors, age-related cognitive decline is an important area in mental health research. Research to find therapeutic medications or supplements to treat cognitive deficits and maintain cognitive health has been ongoing. Ginseng and its active components may have played a role in treating chronic disorders. Numerous preclinical studies have confirmed that ginseng and its active components such as ginsenosides, gintonin, and compound K are pharmacologically efficacious in different models of and are linked to cognitive impairment. Among their several roles, they act as an anti-neuroinflammatory and help fight against oxidative stress and modulate the cholinergic signal. These roles may be involved in enhancing cognition and attenuating impairment. There have been some clinical studies on the activity of ginseng in cognitive impairment, but many ginseng species and active compounds remain to be investigated. In addition, new formulations of active ginseng components such as nanoparticles and liposomes could be used for preclinical and clinical models of cognitive impairment. Here, we discuss the therapeutic potential of active ginseng components in cognitive impairment and their chemistry and pharmacokinetics and consider prospects for their delivery and clinical study with respect to cognitive impairment.

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Section: Prospects For Delivery and Clinical Study Of Ginseng Componementioning

confidence: 99%

Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study

et al. 2018

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“…There are some strategies for these purposes. A few studies reported some drug delivery systems by using natural or synthetic vehicles such as liposome and multicore noisome for enhancement of therapeutic indices of Rh2 15 – 17 . Application of liposome and multicore noisome as drug delivery system is limited by liposomal aggregation and drug leakage.…”

Section: Introductionmentioning

confidence: 99%

“…Application of liposome and multicore noisome as drug delivery system is limited by liposomal aggregation and drug leakage. These problems affected the quality of liposomal systems 17 . In between, nanotechnology and its related compounds have very suitable advantages for application as drug targeting systems.…”

Section: Introductionmentioning

confidence: 99%

New generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activity

Zare‐Zardini

Taheri‐Kafrani

Amiri

et al. 2018

Sci Rep

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In this study, Rh2–treated graphene oxide (GO-Rh2), lysine-treated highly porous graphene (Gr-Lys), arginine-treated Gr (Gr-Arg), Rh2–treated Gr-Lys (Gr-Lys-Rh2) and Rh2–treated Gr-Arg (Gr-Arg-Rh2) were synthesized. MTT assay was used for evaluation of cytotoxicity of samples on ovarian cancer (OVCAR3), breast cancer (MDA-MB), Human melanoma (A375) and human mesenchymal stem cells (MSCs) cell lines. The percentage of apoptotic cells was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The hemolysis and blood coagulation activity of nanostructures were performed. Interestingly, Gr-Arg, Gr-Lys, Gr-Arg-Rh2, and Gr-Lys-Rh2 were more active against cancer cell lines in comparison with their cytotoxic activity against normal cell lines (MSCs) with IC50 values higher than 100 μg/ml. The results of TUNEL assay indicates a significant increase in the rates of TUNEL positive cells by increasing the concentrations of nanomaterials. Results were also shown that aggregation and changes of RBCs morphology were occurred in the presence of GO, GO-Rh2, Gr-Arg, Gr-Lys, Gr-Arg-Rh2, and Gr-Lys-Rh2. Note that all the samples had effect on blood coagulation system, especially on PTT. All nanostrucure act as antitumor drug so that binding of drugs to a nostructures is irresolvable and the whole structure enter to the cell as a drug.

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“…Due to their small size, charge and the possibility for modification and inclusion of targeting moieties, liposomes can be ideal candidates for improved targeting and delivery to the target tissue . Indeed, liposomes can accommodate a wide range of specific adhesion molecules and polymers on their surface, which can aid adhesion to vascular cells . Furthermore, it has been demonstrated that liposomes exhibit enhanced permeability and retention in certain areas of the vasculature, which suggests that it is possible to influence the distribution of liposomes in the cardiovascular system .…”

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confidence: 99%

Integrin Targeting and Toxicological Assessment of Peptide‐Conjugated Liposome Delivery Systems to Activated Endothelial Cells

Kermanizadeh

Villadsen

Østrem

et al. 2017

Basic Clin Pharma Tox

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Utilization of functionalized liposomes as the means of targeted delivery of therapeutics may enhance specific transport of biologically active drugs to target tissues, while avoiding or reducing undesired side effects. In the present investigation, peptide‐conjugated cationic liposomes were constructed with the aim of targeting integrins (i.e. vitronectin and/or fibronectin receptors) on activated endothelial cells. The peptide‐conjugated liposomes induced only cytotoxicity at the highest concentration in non‐activated or activated endothelial cells, as well as in co‐culture of endothelial cells and macrophages. There was unaltered secretion of cytokines after exposure of peptide‐conjugated liposomes to endothelial cells, indicating that the materials were not inflammogenic. Liposomes with a peptide targeting the fibronectin receptor (integrin α5β1) were more effective in targeting of activated endothelial cells, as compared to a liposome with a peptide that targeted both the fibronectin and vitronectin receptors, as well as liposomes with a control peptide. The liposome targeted to the fibronectin receptor also displayed uptake in endothelial cells in co‐culture with activated macrophages. Therefore, this study demonstrates the feasibility of constructing a peptide‐conjugated cationic liposome, which displays targeting to activated endothelial cells at concentrations that are not cytotoxic or inflammogenic to the cells.

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Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons

Cited by 22 publications

References 51 publications

Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study

Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study

New generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activity

Integrin Targeting and Toxicological Assessment of Peptide‐Conjugated Liposome Delivery Systems to Activated Endothelial Cells

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