Liposomes containing nanoparticles: preparation and applications

Leo, Vincenzo De; Maurelli, Anna Maria; Giotta, Livia; Catucci, Lucia

doi:10.1016/j.colsurfb.2022.112737

Cited by 82 publications

(34 citation statements)

References 174 publications

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“…This medicinal form exerted a more expressed and longer effect than other forms (Gutyj et al, 2017). Liposomes play the role of socalled containers for the delivery of medicinal substances, preventing their losses during transportation (De Leo et al, 2022). Therefore, liposomes allow the drug to access the regions of the animal organism which other drug delivery carriers cannot enter (Shahid et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Gutyj

Martyshuk

Парченко

et al. 2022

Regul. Mech. Biosyst.

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The balance between anti- and prooxidants in animal organisms in general and in each cell in particular is responsible for the regulation of many metabolic processes that provide immunocompetence, growth, development and protection of animals from oxidative stress, related to inflow of cadmium and plumbum. Therefore, the objective of our study was the influence of a liposomal drug based on interferon and milk thistle (Silybum marianum (L.) Gaertn.) on the antioxidative status of the organism of bulls in the conditions of cadmium and plumbum loading. The experiments were performed on six-months-old Black Motley dairy cattle. The fodders in the farm were determined to contain high levels of plumbum and cadmium. The liposomal drug Lipointersyl inhibited the lipid peroxidation processes in the bulls. The drug components promoted the decrease in the level of intermediate and end products of lipid peroxidation, in particular 22% decrease in the level of diene conjugates and 20% decrease in TBA-active products. Intramuscular injection of the liposomal drug to bulls of the experimental group strengthened the antioxidant protection of their organism. On the 30th day of the experiment, blood from experimental group animals was seen to have a 9.8% increase in reduced glutathione. Assay of the enzymatic link of the glutathione system revealed that the activity of glutathione peroxidase and glutathione reductase in the blood of the animals that had been injected the liposomal drug Lipointensyl had increased by 24.0% and 27.7% respectively by the 30th day of the experiment. The experiments conducted on young cattle demonstrated that intermuscularly injected the Lipointensyl liposomal drug – against the background of cadmium and plumbum loading – promoted the activation of the glutathione system of antioxidant protection as a result of increase in the activity of its enzymatic and non-enzymatic links. The study of catalase and superoxide dismutase activities revealed that on the 30th and 40th days of the experiment, the activity of those enzymes varied within the physiological norms. Therefore, the analyzed Silybum marianum-based liposomal drug has antioxidant properties, it is recommended for young cattle in the conditions of contamination with heavy metals in order to prevent the development of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Gutyj

Martyshuk

Парченко

et al. 2022

Regul. Mech. Biosyst.

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“…The development of drug carriers is of great significance for clinical translation, and exosomes and liposomes have shown great potential. First, they have a phospholipid bilayer surface that facilitates phagocytosis by target cells; second, they are structurally stable and have some targeting ability; more importantly, they are highly plastic and can be modified to enhance immune evasion and targeting, making them well suited as drug delivery vehicles ( 131 , 132 ). Excitingly, recently, Li et al.…”

Section: Targeting Strategies Worth Considering For Novel Immunomodul...mentioning

confidence: 99%

Immune cells drive new immunomodulatory therapies for myocardial infarction: From basic to clinical translation

Nian

Huang

2023

Front. Immunol.

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The high incidence of heart failure secondary to myocardial infarction (MI) has been difficult to effectively address. MI causes strong aseptic inflammation, and infiltration of different immune cells and changes in the local inflammatory microenvironment play a key regulatory role in ventricular remodeling. Therefore, the possibility of improving the prognosis of MI through targeted immunity has been of interest and importance in MI. However, previously developed immune-targeted therapies have not achieved significant success in clinical trials. Here, we propose that the search for therapeutic targets from different immune cells may be more precise and lead to better clinical translation. Specifically, this review summarizes the role and potential therapeutic targets of various immune cells in ventricular remodeling after MI, especially monocytes/macrophages and neutrophils, as a way to demonstrate the importance and potential of immunomodulatory therapies for MI. In addition, we analyze the reasons for the failure of previous immunomodulatory therapies and the issues that need to be addressed, as well as the prospects and targeting strategies of using immune cells to drive novel immunomodulatory therapies, hoping to advance the development of immunomodulatory therapies by providing evidence and new ideas.

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“…The efficient incorporation of the nanoparticles and the stability of the hybrid system will depend on the intrinsic properties of the nanoparticles, the method of preparation of the lipid system, and the mode of incorporation into the lipid system-incorporated into the lipid phase, incorporated into the aqueous phase, or surface-associated. For example, large hydrophobic nanoparticles incorporated into the liposome bilayer can destabilize the hybrid system [ 71 , 72 ]. The methods for preparing the hybrid system will be according to one of several methods for preparing lipid nanosystems.…”

Section: Techniques For Fabrication Of Hybrid Lipid-magnetic Nanopart...mentioning

confidence: 99%

Hybrid Magnetic Lipid-Based Nanoparticles for Cancer Therapy

et al. 2023

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Cancer is one of the major public health problems worldwide. Despite the advances in cancer therapy, it remains a challenge due to the low specificity of treatment and the development of multidrug resistance mechanisms. To overcome these drawbacks, several drug delivery nanosystems have been investigated, among them, magnetic nanoparticles (MNP), especially superparamagnetic iron oxide nanoparticles (SPION), which have been applied for treating cancer. MNPs have the ability to be guided to the tumor microenvironment through an external applied magnetic field. Furthermore, in the presence of an alternating magnetic field (AMF) this nanocarrier can transform electromagnetic energy in heat (above 42 °C) through Néel and Brown relaxation, which makes it applicable for hyperthermia treatment. However, the low chemical and physical stability of MNPs makes their coating necessary. Thus, lipid-based nanoparticles, especially liposomes, have been used to encapsulate MNPs to improve their stability and enable their use as a cancer treatment. This review addresses the main features that make MNPs applicable for treating cancer and the most recent research in the nanomedicine field using hybrid magnetic lipid-based nanoparticles for this purpose.

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Liposomes containing nanoparticles: preparation and applications

Cited by 82 publications

References 174 publications

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Immune cells drive new immunomodulatory therapies for myocardial infarction: From basic to clinical translation

Hybrid Magnetic Lipid-Based Nanoparticles for Cancer Therapy

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