Liposomes Containing Nickel–Bis(dithiolene) Complexes for Photothermal Theranostics

Ciancone, Mathieu; Bellec, Nathalie; Cammas‐Marion, Sandrine; Dolet, Aneline; Vray, Didier; Varray, François; Goff-Gaillard, Catherine Le; Goff, Xavier Le; Arlot‐Bonnemains, Yannick; Camerel, Franck

doi:10.1021/acs.langmuir.9b01296

Cited by 12 publications

(12 citation statements)

References 61 publications

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“…The photoacoustic signal coming from the nickel‐bis(dithiolene) complex is easily detected and its intensity is directly proportional to the concentration of complex and to the laser energy (Figure ). These last results show that this class of complexes can also be used as exogenous contrast agents for photoacoustic bioimaging …”

Section: Nanoparticlesmentioning

confidence: 77%

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(Photo)Thermal Stimulation of Functional Dithiolene Complexes in Soft Matter

Camerel

Fourmigué

2020

Eur J Inorg Chem

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Square‐planar bis(dithiolene) complexes are characterized with a planar delocalized structure and a strong and tunable near infrared (NIR) absorption; they are highly stable under laser irradiation, and their conversion efficiency (light to heat) reaches up to 40–50 %. Their involvement in soft matter, namely liquid crystals, gels, and nanoparticles, opens many possibilities to control the actual state of a material, particularly under light irradiation. Thus, liquid crystalline phases can easily be modified, (i) with temperature to modulate the extended magnetic interactions of paramagnetic complexes, or (ii) under laser irradiation to unravel these remarkable photothermal properties, toward the development of light‐responsive materials. Dithiolene complexes can be also functionalized to produce very effective gelation agents, while the photothermal effect can be used to destabilize at will their supramolecular organization. Besides photothermal therapy, new therapeutic agents were also developed for photo‐controlled drug delivery and bioimaging, combining chemotherapy and phototherapy. Hydrophobic complexes were accordingly designed for their encapsulation in block copolymer nanoparticles for photothermal therapy and photo‐controlled drug delivery under laser irradiation. This class of complexes can be also used as exogenous contrast agents for photoacoustic bioimaging.

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Section: Nanoparticlesmentioning

confidence: 77%

“…Photoacoustic signal detected depending on the power of laser pulses and on the liposome concentration in DMEM + 10 % FBS medium (standard deviations calculated on 20 images). Reproduced from ref . Copyright (2019), with permission from the American Chemical Society.…”

Section: Nanoparticlesmentioning

confidence: 99%

(Photo)Thermal Stimulation of Functional Dithiolene Complexes in Soft Matter

Camerel

Fourmigué

2020

Eur J Inorg Chem

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“…), which can be modified with necessary moieties (drug, diagnostic agent, vector etc . ). − Because of aforementioned catalytic properties, MePs are often used in theranostics as drugs, and PSs as contrast agents for MRI, positron emission tomography (PET), computer tomography (CT), and near-infrared (NIR) imaging.…”

Section: Theranosticsmentioning

confidence: 99%

Metalloporphyrins in Medicine: From History to Recent Trends

Faustova

Nikolskaya

Sokół

et al. 2020

ACS Appl. Bio Mater.

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The history of metalloporphyrins dates back more than 200 years ago. Metalloporphyrins are excellent catalysts, capable of forming supramolecular systems, participate in oxygen photosynthesis, transport, and used as contrast agents or superoxide dismutase mimetics. Today, metalloporphyrins represent complexes of conjugated π-electron system and metals from the entire periodic system. However, the effect of these compounds on living systems has not been fully understood, and researchers are exploring the properties of metalloporphyrins thereby extending their further application. This review provides an overview of the variety of metalloporphyrins that are currently used in different medicine fields and how metalloporphyrins became the subject of scientists’ interest. Currently, metalloporphyrins utilization has expanded significantly, which gave us an opprotunuty to summarize recent progress in metalloporphyrins derivatives and prospects of their application in the treatment and diagnosis of different diseases.

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“…Among MBD materials, nickel(II) dithiolene complexes have drawn much attention due to their good photothermal stability and strong NIR absorption, which can be adjusted through peripheral ligands . Recently, several nickel(II) dithiolene complexes with high PCE and strong absorption in the NIR were reported. − Mebrouk et al prepared a PEGylated NiBD with great solubility in water and used it as a photothermal agent to induce cell death for the first time . Soon afterward, they encapsulated NiBDs by biocompatible liposomes to release a drug via photothermal control .…”

Section: Introductionmentioning

confidence: 99%

“…Actually, Ciancone et al had found that the MBDs generate ultrasonic signals after being irradiated by lasers. 28 Some MBDs have strong absorption in the NIR region and do not cause photobleaching under long-term NIR irradiation. In addition, they have low cytotoxicity and can be used in bioimaging and therapy.…”

Section: ■ Introductionmentioning

confidence: 99%

Tunable NIR Absorption Property of a Dithiolene Nickel Complex: A Promising NIR-II Absorption Material for Photothermal Therapy

Chen

Fang

Zhang

et al. 2021

ACS Appl. Bio Mater.

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Exogenous photothermal agents absorbing in the second near-infrared optical window (NIR-II, 1000−1700 nm) have received much attention due to their use in noninvasive photothermal therapy. A small quantity of organic NIR-II photothermal agents have been exploited, and the development of organic NIR-II photothermal materials is an urgent need for biological applications. In this study, we designed and synthesized three dithiolene nickel(II) complexes with different ligands bis(phenyl) dithiolene for NiBD-Ph, bis(fluorenyl) dithiolene for NiBD-Fl, and bis(carbazolyl) dithiolene for NiBD-Czand investigated their photophysical properties. These complexes exhibited ligand-dependent NIR absorption performance, centered at 854 nm for NiBD-Ph, 942 nm for NiBD-Fl, and 1010 nm for NiBD-Cz, respectively. NiBD-Cz is wrapped in ethylene oxide/propylene oxide block copolymer (F-127) through a hydrophilic− hydrophobic interaction to form water-soluble NiBD-Cz/F-127 nanoparticles (NiBD-Cz NPs), and the absorption peak of NiBD-Cz NPs are red-shifted to 1036 nm. NiBD-Cz NPs exhibit good dispersibility in water, robust photostability, and a high photothermal conversion efficiency (PCE) of 63.6% under 1064 nm laser irradiation, which is the highest PCE among metal bis(dithiolene) complexes up to now. The high PCE makes it possible to achieve better photothermal treatment effects even at low concentrations and under low-power laser irradiation.

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Liposomes Containing Nickel–Bis(dithiolene) Complexes for Photothermal Theranostics

Cited by 12 publications

References 61 publications

(Photo)Thermal Stimulation of Functional Dithiolene Complexes in Soft Matter

(Photo)Thermal Stimulation of Functional Dithiolene Complexes in Soft Matter

Metalloporphyrins in Medicine: From History to Recent Trends

Tunable NIR Absorption Property of a Dithiolene Nickel Complex: A Promising NIR-II Absorption Material for Photothermal Therapy

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