Liposomes-enabled cancer chemoimmunotherapy

Zhang, Lele; Shi, Jiangpei; Zhu, Mao-Hua; Huang, Yanhu; Lu, Qin; Sun, Peng; Chen, Hong-Zhuan; Lai, Xing; Fang, Chao

doi:10.1016/j.biomaterials.2024.122801

Biomaterials

2025

DOI: 10.1016/j.biomaterials.2024.122801

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Liposomes-enabled cancer chemoimmunotherapy

Lele Zhang,

Jiangpei Shi,

Mao-Hua Zhu

et al.

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A pan‐cancer analysis of the oncogenic and immunological roles of THOC3 in human cancer

Zhang,

Zhao,

Zhao

et al. 2024

Preprint

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Background: There is a limited number of studies on THO Complex Subunit 3 (THOC3) in tumors. The purpose of this study is to conduct a comprehensive analysis of various types of tumors to determine the role of THOC3 in tumor progression and to investigate its impact on immunity. Methods. Retrieved THOC3 expression data from various cancers in the TCGA database and analyzed it using R software (version 3.6.4) and its related packages; explored the differential expression of THOC3 in tumors, its correlation with prognosis, functional enrichment, and its relationship with tumor heterogeneity. The study also aimed to uncover the correlation between THOC3 and tumor immunity. Results. THOC3 is differentially expressed in various tumors and normal samples, and is correlated with overall survival and progression-free time. The study found that THOC3 expression is strongly associated with tumor mutational burden, microsatellite deletion, and immune response. The expression of THOC3 is significantly correlated with immune cell infiltration, and THOC3 can regulate transcription output and mRNA splicing. Therefore, we speculate that THOC3 could serve as a therapeutic target for future anticancer therapies. Conclusions. THOC3 may serve as a novel and specific biomarker for prognosis and immunotherapy.

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A pan‐cancer analysis of the oncogenic and immunological roles of THOC3 in human cancer

Zhang,

Zhao,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Liposomes-enabled cancer chemoimmunotherapy

Cited by 1 publication

References 111 publications

A pan‐cancer analysis of the oncogenic and immunological roles of THOC3 in human cancer

A pan‐cancer analysis of the oncogenic and immunological roles of THOC3 in human cancer

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