Liposomes for the sustained drug release in vivo

Blume, G.; Cevc, Gregor

doi:10.1016/0005-2736(90)90440-y

Cited by 660 publications

(295 citation statements)

References 16 publications

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“…This property has found an immediate application in liposome-mediated drug delivery for it dramatically enhanced the circulation times of the vesicles (Blume & Cevc, 1990;Papahadjopoulos et al, 1991), but has also been very useful in the study of lipid-protein interactions, as in the case of phospholipase C-induced liposome fusion (Basafiez et al, 1997).…”

Section: Membrane Permeabilization and Vesicle Aggregation Can Be Sepmentioning

confidence: 99%

Interaction of wheat α‐thionin with large unilamellar vesicles

Caaveiro

Molina

Rodrı́guez-Palenzuela

et al. 1998

Protein Science

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The interaction of the wheat antibacterial peptide a-thionin with large unilamellar vesicles has been investigated by means of fluorescence spectroscopy. Binding of the peptide to the vesicles is followed by the release of vesicle contents, vesicle aggregation, and lipid mixing. Vesicle fusion, i.e., mixing of the aqueous contents, was not observed. Peptide binding is governed by electrostatic interactions and shows no cooperativity. The amphipatic nature of wheat a-thionin seems to destabilize the membrane bilayer and trigger the aggregation of the vesicles and lipid mixing. The presence of distearoylphosphatidylethanolamine-poly(ethy1ene glycol 2000) (PEG-PE) within the membrane provides a steric barrier that inhibits vesicle aggregation and lipid mixing but does not prevent leakage. Vesicle leakage through discrete membrane channels is unlikely, because the release of encapsulated large fluorescent dextrans is very similar to that of 8-arninonaphthalene-l,3,6,trisulfonic acid (ANTS). A minimum number of 700 peptide molecules must bind to each vesicle to produce complete leakage, which suggests a mechanism in which the overall destabilization of the membrane is due to the formation of transient pores rather than discrete channels.

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Section: Membrane Permeabilization and Vesicle Aggregation Can Be Sepmentioning

confidence: 99%

Interaction of wheat α‐thionin with large unilamellar vesicles

Caaveiro

Molina

Rodrı́guez-Palenzuela

et al. 1998

Protein Science

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“…Such lipid anchors have been realized artificially, e.g. for poly(oxyethylene) also known as polyethylene glycol (PEG) [11][12][13], These anchors are also used in biological systems, for example in order to attach cell adhesion molecules (such as N-CAM 120) to cell membranes [9,10]. For such anchors, the whole polymer chain is located on one side of the membrane.…”

Section: Polymers With Anchorsmentioning

confidence: 99%

Flexible membranes with anchored polymers

Lipowsky

1997

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Compound systems are considered which consist of flexible membranes and polymers. The polymer chains are attached to the membrane surfaces via anchor segments. The non-anchored segments of the polymers, on the other hand, may be repelled from or attracted toward the membranes which leads to desorbed mushrooms or adsorbed pancakes, respectively. These anchored polymers change the local curvature of the membranes. In addition, they can act as adhesive stickers between membranes, a mechanism which underlies the adhesion of biomembranes. © 1997 Elsevier Science B.V.

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“…Liposomes containing either monosialoganglioside G M1 (Allen et al, 1989) or polyethylene glycol (PEG) derivatives (Blume and Cevc, 1990;Klibanov et al, 1990;Allen et al, 1991;Maruyama et al, 1992;Woodle and Lasic, 1992;Yuda et al, 1996) are not readily taken up by the macrophages in reticuloendothelial system (RES), and hence remain in the blood circulation for a relatively long period of time. Particularly, PEG-modified liposomes (PEG liposomes) have been utilized as a particulate carrier for anti-tumor therapy due to their long circulation time.…”

Section: Introductionmentioning

confidence: 99%

Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats

Yokoe

Sakuragi

Yamamoto

et al. 2008

International Journal of Pharmaceutics

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To evaluate the effect of coupling of recombinant human serum albumin (rHSA) onto the surface of poly(ethylene glycol)-modified liposome (PEG liposome) on the in-vivo disposition characteristics of liposomal doxorubicin (DXR), the pharmacokinetics and tissue distribution of DXR were evaluated after intravenous administration of rHSA-modified PEG (rHSA/PEG) liposomal DXR into tumor-bearing rats.rHSA/PEG liposome prepared using a hetero-bifunctional cross-linker, N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP), efficiently encapsulated DXR (over 95%). rHSA/PEG liposomal DXR showed longer blood-circulating property than PEG liposomal DXR and the hepatic and splenic clearances of rHSA/PEG liposomal DXR were significantly smaller than those of PEG liposomal DXR. It was also demonstrated that the disposition of DXR to the heart, one of the organs for DXR-related side-effects, was significantly smaller than free DXR. Furthermore, the tumor accumulation of rHSA/PEG liposomal DXR was significantly larger than that of PEG liposomal DXR. The "therapeutic index", a criterion for therapeutic outcome, for rHSA/PEG liposomal DXR was significantly higher than PEG liposomal DXR. These results clearly indicate that rHSA-conjugation onto the surface of PEG liposome would be a useful approach to increase the effectiveness and safety of PEG liposomal DXR.

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Liposomes for the sustained drug release in vivo

Cited by 660 publications

References 16 publications

Interaction of wheat α‐thionin with large unilamellar vesicles

Interaction of wheat α‐thionin with large unilamellar vesicles

Flexible membranes with anchored polymers

Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats

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