Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery

Basha, Sara Al; Salkho, Najla M; Dalibalta, Sarah; Husseini, Ghaleb A.

doi:10.2174/1389557519666190408155251

Cited by 14 publications

(5 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since tumor cells are known to overexpress receptors that participate in growth and survival pathways, such receptors make promising active targets. To this end, nanocarriers could be conjugated to the natural ligands of these receptors to ensure their accumulation and internalization at the tumor site [ 70 ]. Ideally, these receptors would be tumor neoantigens as these are overexpressed on tumor cells compared to healthy cells.…”

Section: Liposomal-based Smart Drug Deliverymentioning

confidence: 99%

Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

2023

View full text Add to dashboard Cite

To improve currently available cancer treatments, nanomaterials are employed as smart drug delivery vehicles that can be engineered to locally target cancer cells and respond to stimuli. Nanocarriers can entrap chemotherapeutic drugs and deliver them to the diseased site, reducing the side effects associated with the systemic administration of conventional anticancer drugs. Upon accumulation in the tumor cells, the nanocarriers need to be potentiated to release their therapeutic cargo. Stimulation can be through endogenous or exogenous modalities, such as temperature, electromagnetic irradiation, ultrasound (US), pH, or enzymes. This review discusses the acoustic stimulation of different sonosensitive liposomal formulations. Emulsion liposomes, or eLiposomes, are liposomes encapsulating phase-changing nanoemulsion droplets, which promote acoustic droplet vaporization (ADV) upon sonication. This gives eLiposomes the advantage of delivering the encapsulated drug at low intensities and short exposure times relative to liposomes. Other formulations integrating microbubbles and nanobubbles are also discussed.

show abstract

Section: Liposomal-based Smart Drug Deliverymentioning

confidence: 99%

Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

2023

View full text Add to dashboard Cite

show abstract

“…Its extension to Magnetic Resonance guided (MRg) FUS allows for highly accurate spatial localisation and is clinically used for precise ablative treatment of solid tumours and neurological disorders [4]. A less clinically investigated application is the use of MR-guided FUS hyperthermia for targeted drug delivery using thermoresponsive liposomes [5,6].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

MR-labelled liposomes and focused ultrasound for spatiotemporally controlled drug release in triple negative breast cancers in mice

et al. 2021

View full text Add to dashboard Cite

Rationale: Image-guided, triggerable, drug delivery systems allow for precisely placed and highly localised anti-cancer treatment. They contain labels for spatial mapping and tissue uptake tracking, providing key location and timing information for the application of an external stimulus to trigger drug release. High Intensity Focused Ultrasound (HIFU or FUS) is a non-invasive approach for treating small tissue volumes and is particularly effective at inducing drug release from thermosensitive nanocarriers. Here, we present a novel MR-imageable thermosensitive liposome (iTSL) for drug delivery to triple-negative breast cancers (TNBC). Methods: A macrocyclic gadolinium-based Magnetic Resonance Imaging (MRI) contrast agent was covalently linked to a lipid. This was incorporated at 30 mol% into the lipid bilayer of a thermosensitive liposome that was also encapsulating doxorubicin. The resulting iTSL-DOX formulation was assessed for physical and chemical properties, storage stability, leakage of gadolinium or doxorubicin, and thermal-or FUS-induced drug release. Its effect on MRI relaxation time was tested in phantoms. Mice with tumours were used for studies to assess both tumour distribution and contrast enhancement over time. A lipid-conjugated near-infrared fluorescence (NIRF) probe was also included in the liposome to facilitate the real time monitoring of iTSL distribution and drug release in tumours by NIRF bioimaging. TNBC (MDA-MB-231) tumour-bearing mice were then used to demonstrate the efficacy at retarding tumour growth and increasing survival. Results: iTSL-DOX provided rapid FUS-induced drug release that was dependent on the acoustic power applied. It was otherwise found to be stable, with minimum leakage of drug and gadolinium into buffers or under challenging conditions. In contrast to the usually suggested longer FUS treatment we identified that brief (~3 min) FUS significantly enhanced iTSL-DOX uptake to a targeted tumour and triggered near-total release of encapsulated doxorubicin, causing significant growth inhibition in the TNBC mouse model. A distinct reduction in the tumours' average T1 relaxation times was attributed to the iTSL accumulation. Conclusions: We demonstrate that tracking iTSL in tumours using MRI assists the application of FUS for precise drug release and therapy.

show abstract

“…Additionally, acoustic tweezers have no special requirements for materials and do not damage cell activity [20,21]. Due to the incomparable advantages in biological research [22], acoustic tweezers have great research value in applications such as precisely targeted drug delivery [23][24][25], the manipulation of living biological cells [26,27], and remote sample capture and separation [28,29].…”

Section: Introductionmentioning

confidence: 99%

Stable Acoustic Pulling in Two-Dimensional Phononic Crystal Waveguides Based on Mode Manipulation

Gao,

Cao,

Zhu

et al. 2023

Photonics

View full text Add to dashboard Cite

Acoustic manipulation is a set of versatile platforms with excellent manipulation capabilities. In recent years, researchers have increasingly achieved specific manipulations beyond the translation and capture of particles. Here, we focus on the acoustic field momentum mechanism that generates an acoustic radiation force (ARF). A phononic crystal (PC) waveguide is established to amplify the forward momentum of the acoustic beam through the mode conversion of the acoustic field. Based on the conservation of momentum, the object gains reverse momentum. Thus, acoustic pulling can be achieved through the mode conversion of the acoustic field. Furthermore, we analyze the ARFs of two identical objects. It turns out that they can be manipulated separately by opposing forces. Our study provides a new way to achieve stable long-range acoustic pulling, and will explore, beneficially, the interaction between acoustic waves and matter.

show abstract

Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery

Cited by 14 publications

References 101 publications

Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes

MR-labelled liposomes and focused ultrasound for spatiotemporally controlled drug release in triple negative breast cancers in mice

Stable Acoustic Pulling in Two-Dimensional Phononic Crystal Waveguides Based on Mode Manipulation

Contact Info

Product

Resources

About