2018
DOI: 10.1159/000494411
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Liquid Biopsy for the Management of Patients with Colorectal Cancer

Abstract: Background: Liquid biopsy is a collective term that refers to the analysis of tumor-derived biomarkers isolated from biological fluids of cancer patients. Recently, many authors reported the usefulness of liquid biopsy for the management of malignancy. Summary and Key Messages: The peripheral blood of cancer patients is a pool of cells and/or cell products derived from the primary or metastatic tumor, including circulating tumor cells (CTCs), circulating free (cf) DNA or RNA, and exosomes containing proteins, … Show more

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Cited by 60 publications
(52 citation statements)
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“…The few metastatic cases in the cohort following an early dissemination model (and similarly cases that incurred polyclonal seeding of the metastasis) can make it difficult to design effective therapeutic strategies using a single biopsy or limited regions, thus warranting the use of additional clinical intervention, such as liquid biopsies (including circulating cell-free tumour DNA profiling) for early detection and metastasis prevention [ 38 ]. However, these exceptional cases must not overshadow the importance of screening methods for early detection and the excision of the primary tumour, as suitable ways to reduce CRC mortality in most cases.…”
Section: Discussionmentioning
confidence: 99%
“…The few metastatic cases in the cohort following an early dissemination model (and similarly cases that incurred polyclonal seeding of the metastasis) can make it difficult to design effective therapeutic strategies using a single biopsy or limited regions, thus warranting the use of additional clinical intervention, such as liquid biopsies (including circulating cell-free tumour DNA profiling) for early detection and metastasis prevention [ 38 ]. However, these exceptional cases must not overshadow the importance of screening methods for early detection and the excision of the primary tumour, as suitable ways to reduce CRC mortality in most cases.…”
Section: Discussionmentioning
confidence: 99%
“…20,21 Recently, cancer has been considered to be a more heterogeneous disease than previously thought, 22 and discordance between primary and metastatic tumors has been reported. 23 Thus, the detection of spatial and temporal heterogeneity using liquid biopsy will have a great impact, 24 and the present study shows the potential of analyzing both ccfDNA and ctcDNA using combination liquid biopsy.…”
Section: Discussionmentioning
confidence: 67%
“…Tumour cells release cfNAs into the blood stream, urine, ascites, and pleural effusion. Because they contain important information about the parent tumour cells, the analysis of these circulating tumour nucleic acids has the potential to replace tumour‐tissue biopsies in certain diagnostic applications …”
Section: Circulating Tumour Nucleic Acids As Targets For Liquid Biopsymentioning
confidence: 99%