Liquid crystalline pharmacogel based enhanced transdermal delivery of propranolol hydrochloride

Namdeo, Alok; Jain, Narendra Kumar

doi:10.1016/s0168-3659(02)00106-2

Cited by 54 publications

(24 citation statements)

References 20 publications

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“…To support the above fact we performed turbidity measurement studies. Elastic liposomal formulations were prepared at five different concentration levels (5,10,15,20, and 25% w/w of PC) and turbidity was measured in a nephalometer (Superfit, India) taking PBS pH 6.5 as blank. The results of the turbidity measurement studies support the fact of micelles formation at higher concentration of surfactant as turbidity increases with increasing the surfactant concentration whereas at low (15% w/w) concentration of surfactant partition coefficient favors the lipid phase and causes expansion of lipid bilayers resulting in increased turbidity of vesicle dispersion (Tab.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Elastic Liposomes Mediated Transdermal Deliveryof an Anti-Hypertensive Agent: Propranolol Hydrochloride

Mishra

Garg

Dubey

et al. 2007

Journal of Pharmaceutical Sciences

107

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Section: Resultsmentioning

confidence: 99%

“…3,4 The weak intrinsic ability of propranolol hydrochloride to cross the skin has been partially improved using prodrugs, micellar solubilization, and chemical penetration enhancers. [5][6][7] However, all these approaches are not successful in improving the transdermal flux to desired level.…”

Section: Introductionmentioning

confidence: 99%

Elastic Liposomes Mediated Transdermal Deliveryof an Anti-Hypertensive Agent: Propranolol Hydrochloride

Mishra

Garg

Dubey

et al. 2007

Journal of Pharmaceutical Sciences

107

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“…Further addition of water resulted in swelling of the lipid bilayer due to interaction of water with polar groups of surfactants and above a limiting concentration of solvent, the bilayers formed spherical structures randomly giving rise to vesicular structures. 14,21 Morphological characterization of the protransfersomes as well as existence of their vesicular structure after hydration was confirmed by TEM ( Figure 2). Entrapment efficiency of the PTG formulation was high (maximum 96.9 ± 0.4 for PTDF-I 3 ) because of the lipophilic nature of the drug.…”

Section: Preparation and In Vitro Characterization Of Formulationsmentioning

confidence: 87%

Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: Development, characterization, and performance evaluation

et al. 2005

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The present investigation aimed at formulation, performance evaluation, and stability studies of new vesicular drug carrier system protransfersomes for transdermal delivery of the contraceptive agent, levonorgestrel. Protransfersome gel (PTG) formulations of levonorgestrel were prepared and characterized for vesicle shape, size, entrapment efficiency, turbidity, and drug permeation across rat skin and were evaluated for their stability. The system was evaluated in vivo for biological assay of progestational activity including endometrial assay, inhibition of the formation of corpora lutea, and weight gain of uterus. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized PTG formulation showed enhanced in vitro skin permeation flux of 15.82 ± 0.37 μg/cm 2 /hr as compared to 0.032 ± 0.01 μg/cm 2 /hr for plain drug solution. PTG also showed good stability and after 2 months of storage there was no change in liquid crystalline nature, drug content, and other characteristic parameters. The peak plasma concentration of levonorgestrel (0.139 ± 0.05 μg/mL) was achieved within 4 hours and maintained until 48 hours by a single topical application of optimized PTG formulation. In vivo performance of the PTG formulation showed increase in the therapeutic efficacy of drug. Results indicated that the optimized protransfersomal formulation of levonorgestrel had better skin permeation potential, sustained release characteristic, and better stability than proliposomal formulation.

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“…At CGC, these fibers formed a 3D networked skeleton which helped in the immobilization of the MO and GO. [30,31] The formation of the networked structure may be attributed to the apolar-apolar interactions amongst the fatty acyl chains of gelator and oil molecules. Higher hydrophobic interactions amongst the gel components improved the stability of the organogels.…”

Section: Microscopic Studiesmentioning

confidence: 99%

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

Satapathy

Sagiri

Pal

et al. 2013

Designed Monomers and Polymers

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The present study deals with the development and characterization of sorbitan monopalmitate (SM) organogels using mustard oil (MO) and groundnut oil (GO) as the apolar phase. In both the cases, the organogels containing ≥ 20% (w/w) SM were found to be stable for prolonged period. The microscopic studies showed the presence of aggregates of tubular shaped gelator fibers in the gel architecture. Fourier transform infrared spectroscopy indicated formation of intermolecular hydrogen bonding amongst the oil and gelator molecules. Differential scanning colorimetry studies indicated that the thermal stability of GO organogels was found to be more than the MO organogels. Gels showed pseudoplastic flow, with shear thinning and thixotropic behavior. The drug release from the organogels followed Higuchian kinetics with non-Fickian diffusion. The pH values of organogels were found to be near the human skin pH and highly hemocompatible. Metronidazole loaded organogels have shown good antimicrobial activity against Bacillus subtilis. Based on the preliminary studies, the developed organogels may be tried as drug carriers.

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Liquid crystalline pharmacogel based enhanced transdermal delivery of propranolol hydrochloride

Cited by 54 publications

References 20 publications

Elastic Liposomes Mediated Transdermal Deliveryof an Anti-Hypertensive Agent: Propranolol Hydrochloride

Elastic Liposomes Mediated Transdermal Deliveryof an Anti-Hypertensive Agent: Propranolol Hydrochloride

Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: Development, characterization, and performance evaluation

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

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