Liquid lens with adjustable focus for ultrasonic imaging

Li, Zhaoxi; Guo, Rong; Fei, Chunlong; Li, Di; Chen, Dongdong; Zheng, Chenxi; Wu, Ruizhi; Feng, Wei; Yang, Yanchao

doi:10.1016/j.apacoust.2020.107787

Cited by 21 publications

(9 citation statements)

References 29 publications

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“…The laboratory multi-function ultrasonic testing system based on LabView software was a high precision test platform ( Li et al, 2021a , c ). Based on the platform, the emission acoustic fields of ultrasonic transducers with different structures were measured at 400 kHz.…”

Section: Methods and Resultsmentioning

confidence: 99%

An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation

Hou

Fei

et al. 2022

Front. Neurosci.

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Transcranial ultrasound stimulation (TUS) is a young neuromodulation technology, which uses ultrasound to achieve non-invasive stimulation or inhibition of deep intracranial brain regions, with the advantages of non-invasive, deep penetration, and high resolution. It is widely considered to be one of the most promising techniques for probing brain function and treating brain diseases. In preclinical studies, developing miniaturized transducers to facilitate neuromodulation in freely moving small animals is critical for understanding the mechanism and exploring potential applications. In this article, a miniaturized transducer with a half-concave structure is proposed. Based on the finite element simulation models established by PZFlex software, several ultrasound transducers with different concave curvatures were designed and analyzed. Based on the simulation results, half-concave focused ultrasonic transducers with curvature radii of 5 mm and 7.5 mm were fabricated. Additionally, the emission acoustic fields of the ultrasonic transducers with different structures were characterized at their thickness resonance frequencies of 1 MHz using a multifunctional ultrasonic test platform built in the laboratory. To verify the practical ability for neuromodulation, different ultrasound transducers were used to induce muscle activity in mice. As a result, the stimulation success rates were (32 ± 10)%, (65 ± 8)%, and (84 ± 7)%, respectively, by using flat, #7, and #5 transducers, which shows the simulation and experimental results have a good agreement and that the miniaturized half-concave transducer could effectively converge the acoustic energy and achieve precise and effective ultrasonic neuromodulation.

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Section: Methods and Resultsmentioning

confidence: 99%

An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation

Hou

Fei

et al. 2022

Front. Neurosci.

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“…With the help of COMSOL software, Peng et al [ 45 ] proposed an ultrafast ultrasound imaging system for capturing mobile microbubbles, as shown in Figure 6 C, which could be used to control drugs in an accurate location for clinical use. Similarly, Li et al [ 46 ] designed and fabricated an acoustic liquid lens using COMSOL software for a PUT and improved the imaging performance, as shown in Figure 6 D. The results showed that the acoustic liquid lens combined with a 6.8 MHz PUT had a tunable focus, which made accurate imaging in different conditions possible.…”

Section: Traditional Optimization Design Methods For a Putmentioning

confidence: 93%

“… Efficient optimization design software should be developed by integrating the predictive models and intelligent optimization algorithms. Most optimization design methods are developed for a low-frequency PUT [ 28 , 36 , 37 , 40 , 46 ], therefore, an efficient optimization design method for a high-frequency PUT should be proposed and developed in the future. …”

Section: Discussionmentioning

confidence: 99%

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Recent Development and Perspectives of Optimization Design Methods for Piezoelectric Ultrasonic Transducers

et al. 2021

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A piezoelectric ultrasonic transducer (PUT) is widely used in nondestructive testing, medical imaging, and particle manipulation, etc., and the performance of the PUT determines its functional performance and effectiveness in these applications. The optimization design method of a PUT is very important for the fabrication of a high-performance PUT. In this paper, traditional and efficient optimization design methods for a PUT are presented. The traditional optimization design methods are mainly based on an analytical model, an equivalent circuit model, or a finite element model and the design parameters are adjusted by a trial-and-error method, which relies on the experience of experts and has a relatively low efficiency. Recently, by combining intelligent optimization algorithms, efficient optimization design methods for a PUT have been developed based on a traditional model or a data-driven model, which can effectively improve the design efficiency of a PUT and reduce its development cycle and cost. The advantages and disadvantages of the presented methods are compared and discussed. Finally, the optimization design methods for PUT are concluded, and their future perspectives are discussed.

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“…There is an unconventional, but very interesting lens, as shown in Supplementary Figure S14. It can flexibly change the focus point by injecting liquid to control the curvature of the lens (Li et al, 2021b;Li et al, 2021c). It is hard to apply in UHF ultrasonic devices, but some special occasions may play a miraculous effect.…”

Section: Adjustable Focusmentioning

confidence: 99%

A Review of UltraHigh Frequency Ultrasonic Transducers

et al. 2022

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The ultrahigh-frequency (UHF) ultrasonic transducers are active in various fields, including nondestructive evaluation in the semiconductor industry, microscopic biological organization imaging in biomedicine, particle manipulation, and so on. In these fields ultrahigh-frequency (UHF) ultrasonic transducers play a critical role in the performance of related equipment. This article will focus on the topic of ultrahigh-frequency ultrasonic transducers’ preparation, and reviews three aspects: material selection, focus design, and acoustic energy transmission matching. Provides a summary of the current research status, and puts forward some views on the future development of UHF ultrasound devices.

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Liquid lens with adjustable focus for ultrasonic imaging

Cited by 21 publications

References 29 publications

An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation

An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation

Recent Development and Perspectives of Optimization Design Methods for Piezoelectric Ultrasonic Transducers

A Review of UltraHigh Frequency Ultrasonic Transducers

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