Liquid-liquid extraction as a simple tool to quickly quantify fourteen cytostatics in urban wastewaters and access their impact in aquatic biota

Gouveia, Teresa I.A.; Silva, Adrián M.T.; Ribeiro, Ana R.; Alves, Arminda; Santos, Mónica S.F.

doi:10.1016/j.scitotenv.2020.139995

Cited by 41 publications

(14 citation statements)

References 41 publications

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“…By solid addition method, the CoFe2O4@CMC/HZSM-5 point of zero charge (pHpzc) was evaluated. At first, 10 different pH (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) values, 100 mL of KCl solution (0.1 mol/L) was prepared. Then, 0.01 g of the magnetic nanobiocomposite was added to each solution.…”

Section: Adsorption Methodsmentioning

confidence: 99%

“…Removal of complex organic compounds such as antibiotics from water resources with conventional filtration methods due to their sustainability in the environment and nonbiodegradable structure is so difficult. Purification processes including ion exchange [6], membrane filtration [7], solvent extraction [8], electrochemical methods [9], chemical precipitation [10], biological methods [11], electrochemical oxidation [12], catalytic [13,14] and fenton oxidation [15,16] are used for water treatment.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of CoFe2O4@Carboxymethylcellulose/HZSM-5 as a Novel Nano Magnetic Adsorbent for Metronidazole Removal: Isotherm, Kinetic and Thermodynamic Study

Nasiri

Heidari

Javid

et al. 2021

Preprint

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In this research CoFe2O4@CMC/ HZSM-5 synthesized in the presence of Carboxymethylcellulose as a biopolymer in the green conditions as a new nanomagnetic adsorbent for metronidazole removal from aqueous media. Physical and chemical structure of adsorbent was investigated by FTIR, FESEM, EDS, Mapping, TEM, XRD, VSM, BET and TGA techniques. The results indicated that 94% of the metronidazole concentration removed by CoFe2O4@CMC/HZSM-5 in the optimal conditions including pH 6, temperature 20oC, metronidazole concentration 50 mg/L, contact time 60 min and adsorbent dose 2 g/L. The resulting data from adsorption experimental experiments had better correlated with the Freundlich isotherm and pseudo-second order kinetic. Also, the thermodynamic study demonstrated that the adsorption process was an endothermic process and had a physical mechanism. As well as, the achieved findings demonstrated that following six adsorption runs, the adsorbent chemical structure had no change and the nanomagnetic adsorbent efficiency in the removal process had a slight decrease. CoFe2O4@CMC/HZSM-5 magnetic nanocomposite had effective adsorption capacity for metronidazole removal.

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Section: Adsorption Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of CoFe2O4@Carboxymethylcellulose/HZSM-5 as a Novel Nano Magnetic Adsorbent for Metronidazole Removal: Isotherm, Kinetic and Thermodynamic Study

Nasiri

Heidari

Javid

et al. 2021

Preprint

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“…Their partial excretion by oncology patients and animals has led to their continuous discharge into the environment, particularly into the water courses due to their low volatility (Cui et al 2020 ; Ioele et al 2022 ). The presence of antineoplastic drugs in wastewaters and surface waters has been reported worldwide, as long as their inefficient elimination by conventional wastewater treatments currently applied in wastewater treatment plants (WWTPs) (Gouveia et al 2020 ; Khasawneh and Palaniandy 2021 ). Thus, additional treatments to implement in WWTPs, able to effectively remove antineoplastic drugs from wastewaters, is of utmost importance, mitigating their release and accumulation in the environment.…”

Section: Introductionmentioning

confidence: 99%

Theoretical rejection of fifty-four antineoplastic drugs by different nanofiltration membranes

Gouveia,

Alves,

Santos

2023

Environ Sci Pollut Res

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The rise of nanofiltration technologies holds great promise for creating more effective and affordable techniques aiming to remove undesirable pollutants from wastewaters. Despite nanofiltration’s promising potential in removing antineoplastic drugs from liquid matrices, the limited information on this topic makes it important to estimate the rejection rates for a larger number of compounds, particularly the emerging ones, in order to preview the nanofiltration performance. Aiming to have preliminary estimations of the rejection rates of antineoplastic drugs by nanofiltration, 54 antineoplastic drugs were studied in 5 nanofiltration membranes (Desal 5DK, Desal HL, Trisep TS-80, NF270, and NF50), using a quantitative structure-activity relationship (QSAR) model. While this methodology provides useful and reliable predictions of the rejections of compounds by nanofiltration, particularly for hydrophilic and neutral compounds, it is important to note that QSAR results should always be corroborated by experimental assays, as predictions were confirmed to have their limitations (especially for hydrophobic and charged compounds). Out of the 54 studied antineoplastic drugs, 29 were predicted to have a rejection that could go up to 100%, independent of the membrane used. Nonetheless, there were 2 antineoplastic drugs, fluorouracil and thiotepa, for which negligible removals were obtained (<21%). This study’s findings may contribute (i) to the selection of the most appropriate nanofiltration membranes for removing antineoplastic drugs from wastewaters and (ii) to assist in the design of effective treatment approaches for their removal.

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“…To the best of our knowledge, only two works have used other extraction techniques different from SPE for anthracyclines determination. Gouveia et al [23] developed a methodology based on liquid-liquid extraction (LLE) followed by LC-MS for the extraction of 14 antineoplastic compounds including DOX. They obtained a recovery ranging from 105-132% for DOX in sewage and an instrumental detection limit (IDL) of 6.47 ng•L −1 .…”

Section: Introductionmentioning

confidence: 99%

Fabric Phase Sorptive Extraction for the Determination of Anthracyclines in Sewage

et al. 2022

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Anthracyclines are a group of antineoplastic compounds used to treat acute leukemia and other cancers, and they are excreted after consumption by patients. These chemicals are often found in sewage at very low concentration levels. For this reason, the development of sensitive analytical methodologies capable of determining them at low concentrations is of prime importance. A simple, fast and sensitive analytical method using fabric phase sorptive extraction (FPSE) followed by ultra-high performance liquid chromatography with fluorescence detection (UHPLC-FD) has been developed and validated for the extraction of anthracyclines from sewage samples. FPSE is a green, cheap, simple, selective and rapid sample preparation technique. The different parameters that affect the performance of the FPSE process, including extraction time, eluting solvent, elution time and pH, were optimized. The developed method showed satisfactory reproducibility, with intraday and interday RSD values lower than 15% for all the compounds and limits of detection between 0.1–0.15 µg·L−1. The unique combination of sample preparation by this micro-extraction technique with fluorescence detector have resulted in the satisfactory extraction of highly polar anthracyclines, without any noticeable matrix effect, a very common shortcoming of exhaustive sample preparation technique such as solid phase extraction (SPE) and mass spectrometry.

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Liquid-liquid extraction as a simple tool to quickly quantify fourteen cytostatics in urban wastewaters and access their impact in aquatic biota

Cited by 41 publications

References 41 publications

Preparation of CoFe2O4@Carboxymethylcellulose/HZSM-5 as a Novel Nano Magnetic Adsorbent for Metronidazole Removal: Isotherm, Kinetic and Thermodynamic Study

Preparation of CoFe2O4@Carboxymethylcellulose/HZSM-5 as a Novel Nano Magnetic Adsorbent for Metronidazole Removal: Isotherm, Kinetic and Thermodynamic Study

Theoretical rejection of fifty-four antineoplastic drugs by different nanofiltration membranes

Fabric Phase Sorptive Extraction for the Determination of Anthracyclines in Sewage

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