Liquid-Liquid Phase Separation for Analyte Enrichment in Coacervates for Ultra-Sensitive Biosensing
Chaofeng Cen,
Xudong Ma,
Xi Lu
et al.
Abstract:Efficient isolation and concentration of biomolecules are foundational for rapid diagnostics. Traditional methods, often reliant on solid surfaces, necessitate complex and labor-intensive procedures. Liquid-liquid phase separation (LLPS) systems emerged as promising due to their ability to extract biomolecules via the partition effect. Inspired by the biomolecular compartmentalization observed in cellular organelles, we form coacervates via associative LLPS for concentrating a diverse range of biomolecules, si… Show more
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