Liquid marbles with in-flows and out-flows: characteristics and performance limits

Bajwa, Abdullah U.; Xu, Yuhao; Hashmi, Ali; Leong, Matthew; Ho, Ly; Xu, Jie

doi:10.1039/c2sm26748a

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…The mechanical robustness of LM surprisingly allow procedures such as inject and extract liquid from the LM core without destroy them . Bajwa et al reported a deeply study to characterize the behavior and the operational limits of LM upon liquid exchange via external inflow and outflow . They reported that with the liquid injection a swirl motion on the marble surface occurred.…”

Section: Liquid Marblesmentioning

confidence: 99%

“…It was also reported that the liquid can be removed and re‐injected from the LM core and the marbles regained their spherical shape and non‐wetting behavior. With these extraction‐injection cycles, the LM were weakening and disrupted after three cycles . Finally, the authors showed be possible simultaneously inject and extract the liquid from the LM, being possible to use the marbles for perfusion experiments at low flow rates.…”

Section: Liquid Marblesmentioning

confidence: 99%

“…We propose the development of an advanced high‐throughput system for cytotoxic analysis of drugs and materials. The system may incorporate the several steps for this kind of assessment: production of magnetic LM with cells; incubation of cells for the formation of single cell spheroids or 3D cell/microparticle aggregates or co‐culture spheroids (see Figure ); optical morphology assessment of the 3D cell structures; drug/material supply by injection or direct access to the LM core; cellular response assessment by colorimetric methods or electrochemical measurements; by on‐line analysis of results, the sorting of LM can be performed; then using the selected LM, the cells can be maintained in culture on the same platform or moved for other environment by LM burst; cells from the selected conditions can also be used in more powerful methods for cellular evaluation such as flow cytometry . We believe that almost all of these processes can be fully automatized on the proposed device.…”

Section: Critical Analysis: the Potential Of Liquid Marbles For Biomementioning

confidence: 99%

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The Potential of Liquid Marbles for Biomedical Applications: A Critical Review

Oliveira

Reis

Mano

2017

Adv Healthcare Materials

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Liquid marbles (LM) are freestanding droplets covered by micro/nanoparticles with hydrophobic/hydrophilic properties, which can be manipulated as a soft solid. The phenomenon that generates these soft structures is regarded as a different method to generate a superhydrophobic behavior in the liquid/solid interface without modifying the surface. Several applications for the LM have been reported in very different fields, however the developments for biomedical applications are very recent. At first, the LM properties are reviewed, namely shell structure, LM shape, evaporation, floatability and robustness. The different strategies for LM manipulation are also described, which make use of magnetic, electrostatic and gravitational forces, ultraviolet and infrared radiation, and approaches that induce LM self-propulsion. Then, very distinctive applications for LM in the biomedical field are presented, namely for diagnostic assays, cell culture, drug screening and cryopreservation of mammalian cells. Finally, a critical outlook about the unexplored potential of LM for biomedical applications is presented, suggesting possible advances on this emergent scientific area.

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Section: Liquid Marblesmentioning

confidence: 99%

Section: Liquid Marblesmentioning

confidence: 99%

Section: Critical Analysis: the Potential Of Liquid Marbles For Biomementioning

confidence: 99%

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The Potential of Liquid Marbles for Biomedical Applications: A Critical Review

Oliveira

Reis

Mano

2017

Adv Healthcare Materials

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“…dry water or liquid marbles. However, this type of structures has been obtained by using hydrophobic particles [360,361]. Figure 11 shows an idealized picture of the correlations between the contact angle and the curvature of the interface in relation to a water/vapour interface.…”

Section: Beyond the Physico-chemistry: A Brief Perspective To The Pot...mentioning

confidence: 99%

Particle-laden fluid/fluid interfaces: physico-chemical foundations

Guzmán¹,

Abelenda-Núñez²,

Maestro³

et al. 2021

J. Phys.: Condens. Matter

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Particle-laden fluid/fluid interfaces are ubiquitous in academia and industry, which has fostered extensive research efforts trying to disentangle the physico-chemical bases underlying the trapping of particles to fluid/fluid interfaces as well as the properties of the obtained layers. The understanding of such aspects is essential for exploiting the ability of particles on the stabilization of fluid/fluid interface for the fabrication of novel interface-dominated devices, ranging from traditional Pickering emulsions to more advanced reconfigurable devices. This review tries to provide a general perspective of the physico-chemical aspects associated with the stabilization of interfaces by colloidal particles, mainly chemical isotropic spherical colloids. Furthermore, some aspects related to the exploitation of particle-laden fluid/fluid interfaces on the stabilization of emulsions and foams will be also highlighted. It is expected that this review can be used for researchers and technologist as an initial approach to the study of particle-laden fluid layers.

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“…137 In the context of bioreactors and perfusion for long term cell culture, but also more general microuidic requirements, in-ow and outow of liquid into liquid marbles and its effect on marble stability has been studied. 138 Taking advantage of the gas permeable nature of the shell liquid marbles have also been used for culturing aerobic microorganisms. 139 It is also interesting to note a recent report that ips the idea from using liquid marbles as reactors to using them for cryopreservation of mammalian cell lines.…”

Section: Miniature and Micro-bioreactorsmentioning

confidence: 99%

Liquid marbles: topical context within soft matter and recent progress

2015

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The study of particle stabilized interfaces has a long history in terms of emulsions, foams and related dry powders. The same underlying interfacial energy principles also allow hydrophobic particles to encapsulate individual droplets into a stable form as individual macroscopic objects, which have recently been called "Liquid Marbles". Here we discuss conceptual similarities to superhydrophobic surfaces, capillary origami, slippery liquids-infused porous surfaces (SLIPS) and Leidenfrost droplets. We provide a review of recent progress on liquid marbles, since our earlier Emerging Area article (Soft Matter, 2011, 7, 5473-5481), and speculate on possible future directions from new liquid-infused liquid marbles to microarray applications. We highlight a range of properties of liquid marbles and describe applications including detecting changes in physical properties (e.g. pH, UV, NIR, temperature), use for gas sensing, synthesis of compounds/composites, blood typing and cell culture.

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Liquid marbles with in-flows and out-flows: characteristics and performance limits

Cited by 8 publications

References 52 publications

The Potential of Liquid Marbles for Biomedical Applications: A Critical Review

The Potential of Liquid Marbles for Biomedical Applications: A Critical Review

Particle-laden fluid/fluid interfaces: physico-chemical foundations

Liquid marbles: topical context within soft matter and recent progress

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