Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces–an uncontrolled pilot study

Zawar, Vijay; Pawar, Manoj; Reddy, R Raghunatha; Chuh, Antonio

doi:10.1016/j.jaad.2017.10.016

Cited by 6 publications

(9 citation statements)

References 3 publications

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“…To the Editor: We read the pilot study entitled ''Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces-an uncontrolled pilot study,'' published in the May 2018 issue, with keen interest. 1 We found the study flawed. We have the following reservations and comments about this study.…”

mentioning

confidence: 99%

Comment on “Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces-an uncontrolled pilot study”

Tabassum

Rahman

Rashid

2018

Journal of the American Academy of Dermatology

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confidence: 99%

Comment on “Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces-an uncontrolled pilot study”

Tabassum

Rahman

Rashid

2018

Journal of the American Academy of Dermatology

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“…Sample size was calculated using the formula= 4PQ 𝑑 2 Where P is the percentage of side effects observed and 𝑄 = 1 − 𝑃…”

Section: Sample Sizementioning

confidence: 99%

“…There are various topical antifungal therapies available, but they all fail to treat the recurrence and chronicity of the disease. 2 The use of liquid nitrogen cryotherapy in CI helps in removal of macerated hyperkeratotic tissue in web spaces by formation of intracellular ice crystals, causing changes in cellular organelles and disrupting the candida infected cells. 3,4 So far only limited studies are done on this treatment modality which is published.…”

mentioning

confidence: 99%

Cryotherapy with liquid nitrogen for chronic and recalcitrant intertrigo of toe webspaces

Sowmya

Sorake

2021

Int J Res Dermatol

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Background: The inflammation of the toe web spaces is known as foot intertrigo. Most commonly caused by candida. Important predisposing factors such as diabetes mellitus, obesity and immunosuppression lead to persistence and recurrence. Cryotherapy is a promising, safe, cost-effective, easily available therapeutic approach to treat recalcitrant intertrigo compared to available topical medications. Aim of the study was to observe the clinical improvement and therapeutic response of recalcitrant intertrigo and to observe treatment response based on photographs.Methods: A total of 30 patients who were clinically diagnosed with chronic candida intertrigo (CI) who fulfilled the inclusion and exclusion criteria were enrolled. Cryotherapy was administered with 3 cycles of freeze and thaw of 30 seconds each, every 2 weeks for a maximum of 3 treatment sessions. Follow-up of patients were done for 4 months.Results: Among 30 patients treated, 21 patients showed excellent clinical response, 6 patients showed good response. Only 2 patients showed poor response. Minimal side effects were observed, of which transient pain at the cryotherapy site is the most common. Diabetes was the most common comorbidity with poor response to treatment and recurrence.Conclusions: Cryotherapy can be used as a safe modality of treatment for recalcitrant CI cases unresponsive to topical therapy by providing faster therapeutic response and improving the quality of life in these patients.

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“…3 We have already detailed how we confirmed the diagnosis of CI in paragraph 3. 2 However, we appreciate the concerns of Tabassum et al…”

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confidence: 92%

“…After the cryotherapy, we advised the patients to apply mupirocin in the treated parts to prevent secondary infection. 2 It is a standard practice to prescribe topical antibiotics after cryotherapy. 3 We have already detailed how we confirmed the diagnosis of CI in paragraph 3.…”

mentioning

confidence: 99%

Reply to: “Comment on ‘Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces-an uncontrolled pilot study’”

Zawar¹,

Pawar²,

Reddy³

et al. 2018

Journal of the American Academy of Dermatology

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Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces–an uncontrolled pilot study

Cited by 6 publications

References 3 publications

Comment on “Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces-an uncontrolled pilot study”

Comment on “Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces-an uncontrolled pilot study”

Cryotherapy with liquid nitrogen for chronic and recalcitrant intertrigo of toe webspaces

Reply to: “Comment on ‘Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe spaces-an uncontrolled pilot study’”

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