Liquid phantom for investigating light propagation through layered diffusive media

Bianco, Samuele Del; Martelli, Fabrizio; Cignini, Fabio; Zaccanti, Giovanni; Pifferi, Antonio; Torricelli, Alessandro; Bassi, Andrea; Taroni, Paola; Cubeddu, Rinaldo

doi:10.1364/opex.12.002102

Cited by 26 publications

(19 citation statements)

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“…It is worth to stress that for the purposes of this work, as we have previously demonstrated by means of comparisons between measurements on optical calibrated liquid phantoms and MC simulations [29,30], the MC results reproduce correctly the results of calibrated phantom measurements. This evidence strengthens the validity of the presented results.…”

Section: Discussionsupporting

confidence: 72%

“…Experiments measuring the AC and PH contrast on semi-infinite and slab geometries are achievable using calibrated liquid phantoms as those in [29,30]. It is worth to stress that for the purposes of this work, as we have previously demonstrated by means of comparisons between measurements on optical calibrated liquid phantoms and MC simulations [29,30], the MC results reproduce correctly the results of calibrated phantom measurements.…”

Section: Discussionsupporting

confidence: 68%

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Depth sensitivity of frequency domain optical measurements in diffusive media

Binzoni¹,

Sassaroli²,

Torricelli³

et al. 2017

Biomed. Opt. Express

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Abstract:The depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Furthermore, solutions for the relative contrast of AC, PH and DC signals when a totally absorbing plane is placed at a fixed depth of the slab have also been obtained. The solutions have been validated by comparisons with gold standard Monte Carlo simulations. The obtained results show that the AC signal, for modulation frequencies < 200 MHz, has a depth sensitivity with similar characteristics to that of the continuous-wave (CW) domain (source modulation frequency of zero). Thus, the depth probed by such a signal can be estimated by using the formula of penetration depth for the CW domain (Sci. Rep. 6, 27057 (2016)). However, the PH signal has a different behavior compared to the CW domain, showing a larger depth sensitivity at shallow depths and a less steep relative contrast as a function of depth. These results mark a clear difference in term of depth sensitivity between AC and PH signals, and highlight the complexity of the estimation of the actual depth probed in tissue spectroscopy.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 68%

Depth sensitivity of frequency domain optical measurements in diffusive media

Binzoni¹,

Sassaroli²,

Torricelli³

et al. 2017

Biomed. Opt. Express

View full text Add to dashboard Cite

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“…Depth selectivity. A two layered liquid phantom (upper layer thickness: 10 mm, lower layer thickness: 40 mm) was prepared [40] and absorption changes were produced alternatively into the two layers, adding known amounts of black ink. In Fig.…”

Section: Neuropt Protocolmentioning

confidence: 99%

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Re¹,

Contini²,

Turola³

et al. 2013

Biomed. Opt. Express

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Abstract:We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the wavelength space multiplexing approach to reduce wavelength cross-talk and increase signal-to-noise ratio. System performances have been tested on homogeneous and heterogeneous tissue phantoms following specifically designed protocols for photon migration instruments. Preliminary in vivo measurements have been performed to validate the instrument capability to monitor hemodynamic parameters changes in the arm muscle during arterial occlusion and in the adult head during a motor task experiment. ©2013 Optical Society of America

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“…Discrepancies were within the standard deviation of MC results, even when a large number of trajectories (10 8 ) was simulated, and the relative error was as small as 0.01%. The MC program was also previously compared versus experimental results obtaining excellent agreements [28].…”

Section: Monte Carlo Simulationsmentioning

confidence: 99%

Heuristic model for ballistic photon detection in collimated transmittance measurements

Martelli

Binzoni

2018

Opt. Express

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An heuristic model for ballistic photon detection in continuous-wave measurements of collimated transmittance through a slab is presented. The model is based on the small angle approximation and the diffusion equation and covers all the ranges of optical thicknesses of the slab from the ballistic to the diffusive regime. The performances of the model have been studied by means of comparisons with the results of gold standard Monte Carlo simulations for a wide range of optical thicknesses and two types of scattering functions. For a non-absorbing slab and field of view of the receiver less than 3 • the model shows errors less than 15% for any value of the optical thickness. Even for an albedo value of 0.9, and field of view of the receiver less than 3 • the model shows errors less than 20%. These results have been verified for a large set of scattering functions based on the Henyey-Greenstein model and Mie theory for spherical scatterers. The latter has also been used to simulate the scattering function of Intralipid, a diffusive material widely used as reference standard for tissue simulating phantoms. The proposed model represents an effective improvement compared to the existing literature.

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Liquid phantom for investigating light propagation through layered diffusive media

Cited by 26 publications

References 0 publications

Depth sensitivity of frequency domain optical measurements in diffusive media

Depth sensitivity of frequency domain optical measurements in diffusive media

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Heuristic model for ballistic photon detection in collimated transmittance measurements

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