Liquid-solid phase transition alloy as reversible and rapid molding bone cement

Long, Yi; Jin, Chao; Wang, Lei; Jing, Liu

doi:10.1016/j.biomaterials.2014.08.048

Cited by 111 publications

(104 citation statements)

References 77 publications

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“…2e,f). The low LM toxicity was also demonstrated by many researchers in both in vitro 10 and in vivo 101718 studies. Given such high biocompatibility, we believe that LM nanocapsules would be appropriate for biomedical applications.…”

Section: Resultsmentioning

confidence: 65%

“…The next logical step is to test these new chemical functionalized LMs in a variety of biological applications10. Indeed, there is currently great interest in understanding and achieving biomedical approaches of LMs in physiological environments, related to health recovery, imaging or biocompatibility animal evaluation of LMs10161718. Analyses of the biocompatibility, multifunctionalization with bioactive molecules and spatiotemporal control of activities of the chemically modified LM nanocomplexes will be also a milestone for integrating these new materials with numerous biological applications.…”

mentioning

confidence: 99%

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Light-driven liquid metal nanotransformers for biomedical theranostics

et al. 2017

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Room temperature liquid metals (LMs) represent a class of emerging multifunctional materials with attractive novel properties. Here, we show that photopolymerized LMs present a unique nanoscale capsule structure characterized by high water dispersibility and low toxicity. We also demonstrate that the LM nanocapsule generates heat and reactive oxygen species under biologically neutral near-infrared (NIR) laser irradiation. Concomitantly, NIR laser exposure induces a transformation in LM shape, destruction of the nanocapsules, contactless controlled release of the loaded drugs, optical manipulations of a microfluidic blood vessel model and spatiotemporal targeted marking for X-ray-enhanced imaging in biological organs and a living mouse. By exploiting the physicochemical properties of LMs, we achieve effective cancer cell elimination and control of intercellular calcium ion flux. In addition, LMs display a photoacoustic effect in living animals during NIR laser treatment, making this system a powerful tool for bioimaging.

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Section: Resultsmentioning

confidence: 65%

mentioning

confidence: 99%

Light-driven liquid metal nanotransformers for biomedical theranostics

et al. 2017

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“…More importantly, the biosafety of the liquid metal has been discussed thoroughly in some former researches. For example, the liquid-solid phase transition alloy was demonstrated as reversible and rapid molding bone cement [33], and the liquid metal tested as reconnection agent for peripheral nerve injury [34].…”

Section: Introductionmentioning

confidence: 99%

Implantable liquid metal-based flexible neural microelectrode array and its application in recovering animal locomotion functions

Guo

Liu

2017

J. Micromech. Microeng.

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With significant advantages in rapidly restoring the nerve function, electrical stimulation of nervous tissue is a crucial treatment of peripheral nerve injuries leading to common movement disorder. However, the currently available stimulating electrodes generally based on rigid conductive materials would cause a potential mechanical mismatch with soft neural tissues which thus reduces long-term effects of electrical stimulation. Here, we proposed and fabricated a flexible neural microelectrode array system based on the liquid metal GaIn alloy (75.5% Ga and 24.5% In by weight) and via printing approach. Such an alloy with a unique low melting point (10.35 °C) owns excellent electrical conductivity and high compliance, which are beneficial to serve as implantable flexible neural electrodes. The flexible neural microelectrode array embeds four liquid metal electrodes and stretchable interconnects in a PDMS membrane (500 µm in thickness) that possess a lower elastic modulus (1.055 MPa), which is similar to neural tissues with elastic moduli in the 0.1-1.5 MPa range. The electrical experiments indicate that the liquid metal interconnects could sustain over 7000 mechanical stretch cycles with resistance approximately staying at 4 Ω. Over the conceptual experiments on animal sciatic nerve electrical stimulation, the dead bullfrog implanted with flexible neural microelectrode array could even rhythmically contract and move its lower limbs under the electrical stimulations from the implant. This demonstrates a highly efficient way for quickly recovering biological nerve functions. Further, the good biocompatibility of the liquid metal material was justified via a series of biological experiments. This liquid metal modality for neural stimulation is expected to play important roles as biologic electrodes to overcome the fundamental mismatch in mechanics between biological tissues and electronic devices in the coming time.

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“…And upon endocytosis, the nanocarriers would fuse with each other in the mildly acidic endosome microenvironment, leading to drug release. [108] Copyright 2014, Elsevier. a) Liquid metal flexible mechanical joint for human exoskeleton (left) and illastration on its use (right).…”

Section: Drug Deliverymentioning

confidence: 99%

“…This material is proven to be nontoxic in the biocompatible tests and can be easily shaped into various forms at low temperature to fit for various shapes of defects. [108]…”

Section: Bone Substitute Materialsmentioning

confidence: 99%

Preparations, Characteristics and Applications of the Functional Liquid Metal Materials

2017

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As new generation functional materials, the recently emerging low-melting liquid metals have displayed many unconventional properties superior to traditional materials. Various methods, such as alloying, oxidizing, adding metals, or non-metallic materials and so on, have been developed to prepare desirable functional materials based on the gallium or more other metals. These methods could not only change the form of the materials, but also endow the original liquid metals with rather diversified performances, which have further expanded the application range of the low-melting liquid metals to meet various needs. This article aims to review and summarize on the fabrication methods, characteristics, and applications of the functional liquid metal materials. Furthermore, the future outlook in this field, including challenges, routes, and related efforts, has also been illustrated and interpreted.

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Liquid-solid phase transition alloy as reversible and rapid molding bone cement

Cited by 111 publications

References 77 publications

Light-driven liquid metal nanotransformers for biomedical theranostics

Light-driven liquid metal nanotransformers for biomedical theranostics

Implantable liquid metal-based flexible neural microelectrode array and its application in recovering animal locomotion functions

Preparations, Characteristics and Applications of the Functional Liquid Metal Materials

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