Liquorice for pain?

Bell, Rae Frances; Moreira, Vânia M.; Kalso, Eija; Yli‐Kauhaluoma, Jari

doi:10.1177/20451253211024873

Cited by 15 publications

(9 citation statements)

References 88 publications

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“…ex DC. has the highest concentration of flavonoids [98]. Licorice constituents such as glycyrrhizin (28, GLA, Figure 20) and its derivatives (29)(30)(31)(32)(33), and other licorice-derived compounds, such as glabridin and isoliquiritigenin exert these effects via a range of mechanisms, including HMGB1 inhibition, gap junction blockade, and α2 A -adrenoceptor antagonist.…”

Section: Glycyrrhizin Carbenoxolone Licochalcone a Isoliquiritigenin ...mentioning

confidence: 99%

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Turnaturi,

Piana,

Spoto

et al. 2024

Molecules

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Pain is associated with many health problems and a reduced quality of life and has been a common reason for seeking medical attention. Several therapeutics are available on the market, although side effects, physical dependence, and abuse limit their use. As the process of pain transmission and modulation is regulated by different peripheral and central mechanisms and neurotransmitters, medicinal chemistry continues to study novel ligands and innovative approaches. Among them, natural products are known to be a rich source of lead compounds for drug discovery due to their chemical structural variety and different analgesic mechanisms. Numerous studies suggested that some chemicals from medicinal plants could be alternative options for pain relief and management. Previously, we conducted a literature search aimed at identifying natural products interacting either directly or indirectly with opioid receptors. In this review, instead, we have made an excursus including active ingredients derived from plants whose mechanism of action appears from the literature to be other than the modulation of the opioid system. These substances could, either by themselves or through synthetic and/or semi-synthetic derivatives, be investigated in order to improve their pharmacokinetic characteristics and could represent a valid alternative to the opioid approach to pain therapy. They could also be the basis for the study of new mechanisms of action in the approach to this complex and disabling pathology.

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Section: Glycyrrhizin Carbenoxolone Licochalcone a Isoliquiritigenin ...mentioning

confidence: 99%

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Turnaturi,

Piana,

Spoto

et al. 2024

Molecules

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“…Glycyrrhizin, its metabolite glycyrrhetic (glycyrrhetinic) acid and other liquorice‐derived compounds such as isoflavonoids and trans ‐chalcones exert potent antiinflammatory effects via a wide range of mechanisms including high mobility group box 1 protein (HMGB1) inhibition, gap junction blockade, and α 2A ‐adrenoceptor antagonism. These properties, together with an increasing body of preclinical studies and a long history of use in herbal medicine, suggest that liquorice constituents may be useful for pain managemen (Bell, Moreira, Kalso, & Yli‐Kauhaluoma, 2021).…”

Section: Findingmentioning

confidence: 99%

An overview of the effect of medicinal herbs on pain

Yousofvand

Moloodi

2022

Phytotherapy Research

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This paper is typically intended to carefully collect and properly review the antinociceptive activities of medicinal plants. In this review article, by searching keywords of medicinal plants, pain, herbal medicine, antinociceptive, phytotherapy in databases of Web of Science, Scopus, Google Scholar, Springer, Wiley, Proquest, PubMed, Nature, Magiran, Emerald, SID, ISI, and some other indexing cites, or traditional books, desired articles were obtained until 2021. The title of medicinal plants was searched diligently in Persian and English. Ultimately, 270 articles were studied. The findings possibly indicated that several medicinal plants are among the most valuable plants that have antinociceptive activities. There efficiently are various antinociceptive compounds in medicinal plants. The antinociceptive activity of these specific compounds may be through their peculiar effects on the opioid system, cholinergic pathways, and stimulation of GABA receptors, with the peripheral and central antinociceptive mechanism. Antiinflammatory processes, inhibition of the synthesis, and the release of arachidonic acid, prostaglandins, phospholipase, nitric oxide, and cyclooxygenase‐2 have been reported as analgesic mechanisms of some herbs. In a reasonable conclusion, our review thoughtfully provides a comprehensive summary of present data from some scientific studies on the common herbs with antinociceptive and antiinflammatory activities.

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“…Licorice is also used as a natural sweetener for food and confectionery. The accumulated data on biological activity suggest that licorice exerts antibacterial, antiviral, anti-inflammatory, anticancer, antioxidant, liver protection, neuroprotection, skin whitening, hypoglycemic, memory-enhancing, and other biological activities [ 68 , 69 , 70 , 71 ].…”

Section: Preparation Of the Immunoaffinity Column With Mabs Against Bioactive Natural Compounds And One-step Separation Of Natural Compoumentioning

confidence: 99%

Immunological Separation of Bioactive Natural Compounds from Crude Drug Extract and Its Application for Cell-Based Studies

et al. 2021

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In this study, we present a review on a useful approach, namely, immunoaffinity column coupled with monoclonal antibodies (MAbs), to separate natural compounds and its application for cell-based studies. The immunoaffinity column aids in separating the specific target compound from the crude extract. The column capacity was stable even after more than 10 purification cycles of use under the same conditions. After applying the crude extract to the column, the column was washed with washing buffer and eluted with elution buffer. The elution fraction contained the target compound bound to MAb, whereas the washing fraction was the crude extract, which contained all compounds except a group of target compounds; therefore, the washing fraction was referred to as a knockout (KO) crude extract. Cell-based studies using the KO extract revealed the actual effects of the natural compounds in the crude extract. One-step separation of natural compounds using the immunoaffinity column coupled with MAbs may help in determining the potential functions of natural compounds in crude extracts.

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Liquorice for pain?

Cited by 15 publications

References 88 publications

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

An overview of the effect of medicinal herbs on pain

Immunological Separation of Bioactive Natural Compounds from Crude Drug Extract and Its Application for Cell-Based Studies

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