Lisosan G, a powder of grain, does not interfer with the drug metabolizing enzymes and has a protective role on carbon tetrachloride-induced hepatotoxicity

Abstract

Lisosan G is a powder of grain registered as an alimentary integrator. The treatment of rats for 4 days with 0.5 g Lisosan G/kg had no effect on various drug metabolizing enzymes. Experiments in vitro showed that Lisosan G had radical scavenger activity. A confirmation of the antioxidative property of Lisosan G was also confirmed when it was administered in vivo to carbon tetrachloride (CCl(4))-intoxicated rats. The toxicity caused by CCl(4)-treatment of rats was restored to the control levels when the rats were given Lisosan G for 4 days before CCl(4). Lisosan G thus does not interfere with drug metabolizing system but has antioxidant properties and protects against CCl(4)-induced hepatotoxicity.

The effects of fermented wheat powder (Lisosan G) on the blood lipids and oxidative status of healthy rabbits

“…However, the bilirubin level decreased slightly in the Lisosan G fed rabbits. The results on the lack of hepatoxicity of Lisosan G confirmed the results of a previous study on rats, in which a protective role of carbon tetrachlorideinduced hepatotoxicity was observed (Longo et al, 2007).…”

“…The antioxidant activity of Lisosan G was previously evaluated through in vitro and in vivo experiments (Longo et al, 2007;Frassinetti et al, 2012;La Marca et al, 2013;Longo et al, 2014). Frassinetti et al (2012) demonstrated that Lisosan G removed the free radicals that originated from a normal aerobic metabolism and increased CAT, glutathione peroxidase (GPX) and superoxide dismutase (SOD).…”

“…The main components of Lisosan G have already been reported in previous studies (Longo et al, 2007. The commercial rabbit diet was provided by Agri-zoo SNC (Miranda, Isernia, Italy); the ingredients and chemical composition of the diets are reported in Table 1.…”

“…When the fermentation has been completed, the product is dried and the resulting dry powder is Lisosan G (Longo et al, 2007). Lisosan G is rich in several bioactive compounds, such as polyphenols and especially flavonoids and flavonols, lipoic acid, tocopherols and polyunsaturated fatty acids.…”

“…In vivo, Lisosan G has been shown to protect against toxicity induced by cisplatin (Longo et al, 2011) and to present antioxidant activity that does not interfere with the drug-metabolizing system (Longo et al, 2007) of rats. In vitro, Lisosan G has been show to help to prevent microcirculatory dysfunction (Lubrano et al, 2012).…”