Listerial myocarditis as a complication of Listerial meningoencephalitis

Strnadel, Matěj; Hnátek, Tomáš; Havlicek, Roman; Krčová, Eva; Malý, Martin; Zavoral, Miroslav

doi:10.1016/j.crvasa.2017.02.004

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…(e.g . S. aureus ) Oligopeptides, thiolactone, PlcR, Npr, and PapR (autoinducing peptides) [166,167, 168] Endocarditis (Fernández Guerrero et al 2007 ; Guerrero et al 2009 ; Thomas et al 2012 ; Ferrand et al 2013 ; Lamond et al 2021 ); myocarditis (McGee et al 2018 ; Strnadel et al 2018 ) Gram-negative bacteria Escherichia coli Autoinducer (AI)-3 (Zhou et al 2016 ) Endocarditis (Quiring and Burke 2021 ) Stenotrophomonas Maltophilia (Xanthomonas maltophilia and Pseudomonas maltophilia), X. campestris Homologue of farnesoic acid: cis-11-methyl-2-dodecenoic acid, α,β unsaturated fatty acid (diffusible signal factor, DSF) [178,179] Endocarditis (Mehta et al 2000 ) Acinetobacter sp . (A. baumannii), Aeromonas hydrophyla, Pseudomonas sp ., Serratia marcescens, and Yersinia sp .…”

Section: Emerging Role Of Cardiac Bitter Taste Receptors In Cardiac I...mentioning

confidence: 99%

Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases

2022

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Heart diseases and related complications constitute a leading cause of death and socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic mechanisms of these diseases, the underlying cellular and molecular mechanisms are yet to be completely understood. Several lines of evidence indicate a critical role of inflammatory and oxidative stress responses in the development and progression of heart diseases. Nevertheless, the molecular machinery that drives cardiac inflammation and oxidative stress is not completely known. Recent data suggest an important role of cardiac bitter taste receptors (TAS2Rs) in the pathogenetic mechanism of heart diseases. Independent groups of researchers have demonstrated a central role of TAS2Rs in mediating inflammatory, oxidative stress responses, autophagy, impulse generation/propagation and contractile activities in the heart, suggesting that dysfunctional TAS2R signalling may predispose to cardiac inflammatory and oxidative stress disorders, characterised by contractile dysfunction and arrhythmia. Moreover, cardiac TAS2Rs act as gateway surveillance units that monitor and detect toxigenic or pathogenic molecules, including microbial components, and initiate responses that ultimately culminate in protection of the host against the aggression. Unfortunately, however, the molecular mechanisms that link TAS2R sensing of the cardiac milieu to inflammatory and oxidative stress responses are not clearly known. Therefore, we sought to review the possible role of TAS2R signalling in the pathophysiology of cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases. Potential therapeutic significance of targeting TAS2R or its downstream signalling molecules in cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction is also discussed.

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