Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats

Wang, Yilong; An, Xiaohu; Zhang, Xiaoqing; Liu, Jianhui; Wang, Jianwei; Yang, Zeyong

doi:10.1002/2211-5463.12779

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…In contrast, all of these gene expressions reduced significantly in LiCl treated cells. Similar results were also observed in the study of the antiviral effects of LiCl on coxsackie virus [26] and Sendai virus [27]. This result suggests that the anti-viral effect of LiCl on MDV might not depend on the expression of interferon and interferon-related factors.…”

Section: Discussionsupporting

confidence: 87%

Antiviral Effect of Lithium Chloride on Replication of Marek’s Disease Virus in Chicken Embryonic Fibroblasts

Qiao

et al. 2021

IJMS

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To investigate the antiviral effect of lithium chloride (LiCl) on the replication of Marek’s disease virus (MDV) in chicken embryonic fibroblast (CEF) cells, real-time PCR, Western blotting, plaque counting, and indirect immunofluorescence experiments were performed at different time points of LiCl treated CEF cells with virus infection. The results demonstrated that LiCl could affect multiple steps of virus replication and inhibit viral gene expression and protein synthesis in a dose- and time-dependent manner. Moreover, LiCl could directly affect viral infectivity as well. In addition, LiCl significantly affected the gene expression of IFN-β related genes in virus-infected cells. These results indicate that LiCl significantly inhibits MDV replication and proliferation in CEF cells and it has the potential to be used as an antiviral agent against MDV.

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Section: Discussionsupporting

confidence: 87%

Antiviral Effect of Lithium Chloride on Replication of Marek’s Disease Virus in Chicken Embryonic Fibroblasts

Qiao

et al. 2021

IJMS

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“…It is interesting to note that we found a significant increase in NLGN clusters upon lithium treatment despite plasma levels falling just below the clinically relevant therapeutic range. It is tempting to speculate that the synaptogenic effects of Li do not underlie the improvement in the core BD symptoms of mania and depression, which are the main clinical measures to assess treatment efficacy in BD, but rather contribute to some therapeutic benefit of Li that is less well established such as reducing cognitive decline 65 . However, more work is needed to understand the exact implications of these results for the effect of treatment in BD.…”

Section: Implications For Human Studiesmentioning

confidence: 99%

Contrasting effects of chronic lithium, haloperidol and olanzapine exposure on synaptic clusters in the rat prefrontal cortex

Halff

Cotel

Natesan

et al. 2020

Preprint

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The pathophysiology of the majority of neuropsychiatric disorders, including schizophrenia and mood disorders, involves synaptic dysfunction and/or loss, manifesting as lower levels of several presynaptic and postsynaptic marker proteins. Whether chronic exposure to antipsychotic drugs may contribute to this pattern of synaptic loss remains controversial. In contrast, the mood stabiliser lithium has shown to exhibit neurotrophic actions and is thought to enhance synapse formation. Whilst these data are not unequivocal, they suggest that antipsychotic drugs and lithium have contrasting effects on synapse density. We therefore investigated the effect of chronic exposure to lithium and to two different antipsychotics, haloperidol and olanzapine, on presynaptic Synaptic Vesicle glycoprotein 2A (SV2A) and postsynaptic Neuroligin (NLGN) clusters in the rat frontal cortex. Chronic exposure (28 days) to haloperidol (0.5 mg/kg/d) or olanzapine (7.5 mg/kg/d) had no effect on either SV2A or NLGN clusters and no overall effect on synaptic clusters. In contrast, chronic lithium exposure (2 mmol/L eq./d) significantly increased NLGN cluster density as compared to vehicle, but did not affect either SV2A or total synaptic clusters. These data are consistent with and extend our prior work, confirming no effect of either antipsychotics or lithium on SV2A clustering, but suggest contrasting effects of these drugs on the post-synapse. Although caution needs to be exerted when extrapolating results from animals to patients, these data provide clarity with regard to the effect of antipsychotics and lithium on synaptic markers, thus facilitating discrimination of drug from illness effects in human studies of synaptic pathology in psychiatric disorders.

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“…Because anaesthetic choice can be effectively managed by anaesthesiologists, it is important to determine the role of anaesthetic choice in POCD. Propofol and sevoflurane are common general anaesthetics used in clinical anaesthesia, and animal experiments have also shown that propofol and sevoflurane can cause the occurrence of POCD ( 15 , 16 ). The choice of anaesthetic may affect cognitive outcome after the operation, but the results from clinical research have always been contradictory.…”

Section: Introductionmentioning

confidence: 99%

Propofol Versus Sevoflurane General Anaesthesia for Selective Impairment of Attention Networks After Gynaecological Surgery in Middle-Aged Women: A Randomised Controlled Trial

et al. 2022

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PurposeAttention is an essential component of cognitive function that may be impaired after surgery with anaesthesia. Propofol intravenous anaesthesia and sevoflurane inhalational anaesthesia are frequently used in gynaecological surgery. However, which type of anaesthetic has fewer cognitive effects postoperatively remains unclear. We compared the differences in attention network impairment after surgery in women receiving propofol versus sevoflurane general anaesthesia.Patients and MethodsEighty-three patients with gynaecological diseases who were 40–60 years of age were involved in the study. All patients underwent elective gynaecological surgery under either total intravenous anaesthesia or sevoflurane inhalational anaesthesia, depending on randomisation. The efficiencies of the three attention networks were captured using the attention network test preoperatively and on the 1st and 5th postoperative days.ResultsBoth groups of patients showed differences in impairments on the 1st and 5th postoperative days. Pairwise comparisons indicated that the alerting and orienting networks of patients in the propofol group were impaired to a greater extent than those of patients in the sevoflurane group on the 1st postoperative day, while the executive control network was impaired to a lesser extent. On the 5th postoperative day, the alerting networks of both groups recovered to the baseline level. Patients in the propofol group still showed impairment of the orienting network, while patients in the sevoflurane group recovered to baseline. For the executive control network, patients in the sevoflurane group still exhibited more severe impairment than those in the propofol group.ConclusionIn middle-aged women, propofol impaired orienting and alerting networks more than sevoflurane, while sevoflurane showed more residual impairment of the executive control network.

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Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats

Cited by 7 publications

References 39 publications

Antiviral Effect of Lithium Chloride on Replication of Marek’s Disease Virus in Chicken Embryonic Fibroblasts

Antiviral Effect of Lithium Chloride on Replication of Marek’s Disease Virus in Chicken Embryonic Fibroblasts

Contrasting effects of chronic lithium, haloperidol and olanzapine exposure on synaptic clusters in the rat prefrontal cortex

Propofol Versus Sevoflurane General Anaesthesia for Selective Impairment of Attention Networks After Gynaecological Surgery in Middle-Aged Women: A Randomised Controlled Trial

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