Lithium-Containing Bioactive Glasses for Bone Regeneration

Durand, Luis; Vargas, Gabriela E.; Gramajo, Fátima Cecilia Gómez; Mesones, Rosa Vera; Pacheco, Valentina Miguez; Boccaccını, Aldo R.; Alonso, Alejandro Adrian Gorustovich

doi:10.1016/b978-0-08-102196-5.00007-0

Cited by 7 publications

(8 citation statements)

References 57 publications

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“…Sodium is involved in the generation of nerve impulses and maintaining electrolyte and fluid balances while lithium can affect the behavior of neurons, several enzymes and signaling pathways as well as contributing to angiogenic effects. 16,22 LP can be added to hydrogels as inorganic filler to form hydrogel nanocomposites, which usually provide superior properties, especially mechanical ones, viscoelasticity and positive effects on cell-material interactions for numerous applications. 4,16,17,23 Li et al 19 illustrated that the addition of LP into alginate gels can not only raise drug encapsulation efficiency but also promotes the release efficiency of methylene blue in acidic conditions compared with pure alginate gels.…”

Section: Introductionmentioning

confidence: 99%

Potential of Laponite® incorporated oxidized alginate–gelatin (ADA‐GEL) composite hydrogels for extrusion‐based 3D printing

2020

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The concept of adding inorganic fillers into hydrogels to form hydrogel nanocomposites often provides advantageous properties which can be exploited for successful 3D biofabrication. In this study, a new composite hydrogel combining oxidized alginate-gelatin (ADA-GEL) hydrogel and Laponite ® nanoclay as inorganic nanofiller was successfully developed and characterized. The results showed that the addition of 0.5% (wt/vol) Laponite ® nanoplatelets improved the printability of ADA-GEL hydrogels enabling the fabrication of detailed structures since a low effect of material spreading and reduced tendency to pore closure appeared. Furthermore, a comparison of different needle types (cylindrical and conical; same inner diameter of 250 μm) in filament fusion test showed that the pattern dispensed by cylindrical tip has enhanced printing accuracy and pattern fidelity when compared with the pattern from conical tip. A glass flip test determined a processing window of 1-2 h after composite ink preparation. Overall, Laponite ® /ADA-GEL hydrogel composites are confirmed as promising inks for 3D bioprinting.

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Section: Introductionmentioning

confidence: 99%

Potential of Laponite® incorporated oxidized alginate–gelatin (ADA‐GEL) composite hydrogels for extrusion‐based 3D printing

2020

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“…In Figure 8 it can be observed that the band at approximately 510 cm −1 (45S5_0h, 45S5_1h, 45S5_2h, 45S5_4h) was split into two bands, approximately at about 520 and 460 cm −1 (45S5_8h, 45S5_16h). These bands were assigned to the bending vibrations of -O-Si-Oand (Si)O-Si-O(Si), respectively [1][2][3][4]. In the analyzed glass-ceramic materials (45S5_8h and 45S5_16h) these were characteristic bands for Na6Ca3(Si6O18) cyclosilicate [37].…”

Section: Structure Studymentioning

confidence: 96%

“…Since 1969, 45S5 Bioglass ® has been the first and the best know bioactive glass and it is widely used as a bone and tissue replacement because of its excellent biocompatibility [1][2][3]. It is classified as a class A bioactive glass, which means that this material is osteoconductive and osteoproductive and exhibits the highest rate of hydroxyapatite (HA) formation in vitro and in vivo that are necessary for tissue engineering applications [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Crystallization Kinetics and Structural Properties of the 45S5 Bioactive Glass and Glass-Ceramic Fiber Doped with Eu3+

et al. 2020

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An investigation of the crystallization kinetics of 45S5 Bioglass® using differential scanning calorimetry is presented in this paper. Thermal analysis was performed using the Friedman method. The activation energy and the Avrami index were calculated. The glass samples were subjected to additional controlled heat treatment at 620 °C in order to obtain bioactive glass-ceramics with enhanced mechanical properties. X-ray powder diffraction (XRD) measurements indicated the formation of the glass-ceramic structures of three cyclosilicates: Na4Ca4(Si6O18) or Na6Ca3(Si6O18) or Na16Ca4(Si12O36). Based on middle infrared region (MIR) results, it can be concluded that the crystalline phase present in the tested materials was Na6Ca3(Si6O18) (combeite). Material was doped with Eu3+ ions, which act as a spectroscopic probe for monitoring the structural changes in the glass matrix. The decreasing value of the fluorescence intensity radio parameter indicated symmetry around the europium ions and, thus, the arrangement of the glass structure. The bioactive properties of the examined glass-ceramics were also determined. The bioactive glass fibers doped with Eu3+ were manufactured using two different methods. Its structural and luminescent properties were examined.

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“…An advantage of BGs is the inclusion of various ions to their structure to improve their performance. In recent years, one of the ions added to the structure of BG is Li; Li-BG is commonly used in bone regeneration and osteochondral repair [ 205 ]. For instance, a study investigated the biocompatibility and bioactivity of 45S5 Li-BG that was prepared by a melt quenching method.…”

Section: Lithium-doped Bioceramics In Regenerative Medicinementioning

confidence: 99%

“…Exposure to 45S5.5 Li-BG ionic dissolution products improved angiogenesis by increasing integrin αvβ3 subunit β3 expression and vascular density in quail embryo CAMs. The ionic dissolution products of 45S5.5 Li-doped BGs can be considered inorganic angiogenic agents, which can be used in place of expensive and potentially harmful growth factors [ 205 , 228 , 229 ]. It has also been claimed that Si and Li-ions have synergistic effects on the activation of the WNT/β-catenin canonical pathway and the production of proangiogenic cytokines (insulin growth factor 1 (IGF1) and TGF- β) [ 205 , 230 ].…”

Section: Lithium-doped Bioceramics In Regenerative Medicinementioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

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Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

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Lithium-Containing Bioactive Glasses for Bone Regeneration

Cited by 7 publications

References 57 publications

Potential of Laponite® incorporated oxidized alginate–gelatin (ADA‐GEL) composite hydrogels for extrusion‐based 3D printing

Potential of Laponite® incorporated oxidized alginate–gelatin (ADA‐GEL) composite hydrogels for extrusion‐based 3D printing

Crystallization Kinetics and Structural Properties of the 45S5 Bioactive Glass and Glass-Ceramic Fiber Doped with Eu3+

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

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