Little things with significant impact: miRNAs in hepatocellular carcinoma

Li, Jiehan; Bao, Haolin; Huang, Ziyue; Liang, Zixin; Wang, Mei; Lin, Ning; Ni, Chunjie; Xu, Yi

doi:10.3389/fonc.2023.1191070

Cited by 8 publications

(6 citation statements)

References 145 publications

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“…The combination of the two often has a synergistic effect and improves the prognosis of HCC patients. During the use of these systems for treatment, changes in miRNA expression profiles and levels in HCC patients may have important value in predicting drug efficacy, drug-related adverse events and prognosis[ 66 ].…”

Section: Discussionmentioning

confidence: 99%

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

Zhang,

Chen,

Wei

et al. 2024

World J Clin Oncol

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BACKGROUND Emerging research suggests that microRNAs (miRNAs) play an important role in the development of hepatocellular carcinoma (HCC). A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further studies. AIM To make a comprehensive analysis of recent studies concerning miRNAs in HCC. METHODS All relevant publications were retrieved from the Web of Science Core Collection database. Bibliometrix software, VOSviewer software and CiteSpace software were used to visually analyze the distribution by time, countries, institutions, journals, and authors, as well as the keywords, burst keywords and thematic map. RESULTS A total of 9426 publications on this topic were found worldwide. According to the keywords analysis, we found that the studies of miRNAs focused on their expression level, effects, and mechanisms on the biological behaviour of HCC. Keywords bursting analysis showed that in the early years (2013–2017), “microRNA expression”, “gene expression”, “expression profile”, “functional polymorphism”, “circulating microRNA”, “susceptibility” and “mir 21” started to attract attention. In the latest phase (2018–2022), the hot topics turned to “sorafenib resistance”, “tumor microenvironment” and so on. CONCLUSION This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric analysis. The hotspots in this field focus on miRNAs expression level, effects, and mechanisms on the biological behavior of HCC. The frontiers turned to sorafenib resistance, tumor microenvironment and so on.

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Section: Discussionmentioning

confidence: 99%

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

Zhang,

Chen,

Wei

et al. 2024

World J Clin Oncol

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“…Furthermore, chemotherapy induces the translation of circMRPS35, amplifying the malignant progression while simultaneously developing chemotherapeutic resistance. In another paper by Jiehan et al, miRNA-130b-3p expression was shown to be significantly increased in HCC and downregulated its expression by directly targeting (Homeobox protein Hox-A5), which further activated the PI3K/AKT/mTORpathway, thereby stimulating HCC cells to induce capillary tube formation, endothelial cell migration, and proliferation ( Li et al, 2023 ).…”

Section: Roles Of Microrna In the Livermentioning

confidence: 99%

Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges

El Hayek,

Alnaser-Almusa,

Alsalameh

et al. 2024

Front. Mol. Biosci.

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Exosomal microRNAs (miRNAs) have great potential in the fight against hepatocellular carcinoma (HCC), the fourth most common cause of cancer-related death worldwide. In this study, we explored the various applications of these small molecules while analyzing their complex roles in tumor development, metastasis, and changes in the tumor microenvironment. We also discussed the complex interactions that exist between exosomal miRNAs and other non-coding RNAs such as circular RNAs, and show how these interactions coordinate important biochemical pathways that propel the development of HCC. The possibility of targeting exosomal miRNAs for therapeutic intervention is paramount, even beyond their mechanistic significance. We also highlighted their growing potential as cutting-edge biomarkers that could lead to tailored treatment plans by enabling early identification, precise prognosis, and real-time treatment response monitoring. This thorough analysis revealed an intricate network of exosomal miRNAs lead to HCC progression. Finally, strategies for purification and isolation of exosomes and advanced biosensing techniques for detection of exosomal miRNAs are also discussed. Overall, this comprehensive review sheds light on the complex web of exosomal miRNAs in HCC, offering valuable insights for future advancements in diagnosis, prognosis, and ultimately, improved outcomes for patients battling this deadly disease.

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“…At the same time, by similarly acting, specific related lncRNAs and sncRNAs have been demonstrated to be actively involved in cancer-related chemoresistance processes, representing potential tools to optimize therapeutic approaches even in HCC management [72]. Based on this, in the last few decades, various encouraging results have emerged from the dramatic amount of research exploring potential ncRNA HCC-therapeutic targets [182,183].…”

Section: Potential Ncrna Applications In Hcc Treatment: a Close-to-ex...mentioning

confidence: 99%

Role of Non-Coding RNAs in Hepatocellular Carcinoma Progression: From Classic to Novel Clinicopathogenetic Implications

Romeo,

Dallio,

Scognamiglio

et al. 2023

Cancers

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Hepatocellular carcinoma (HCC) is a predominant malignancy with increasing incidences and mortalities worldwide. In Western countries, the progressive affirmation of Non-alcoholic Fatty Liver Disease (NAFLD) as the main chronic liver disorder in which HCC occurrence is appreciable even in non-cirrhotic stages, constitutes a real health emergency. In light of this, a further comprehension of molecular pathways supporting HCC onset and progression represents a current research challenge to achieve more tailored prognostic models and appropriate therapeutic approaches. RNA non-coding transcripts (ncRNAs) are involved in the regulation of several cancer-related processes, including HCC. When dysregulated, these molecules, conventionally classified as “small ncRNAs” (sncRNAs) and “long ncRNAs” (lncRNAs) have been reported to markedly influence HCC-related progression mechanisms. In this review, we describe the main dysregulated ncRNAs and the relative molecular pathways involved in HCC progression, analyzing their implications in certain etiologically related contexts, and their applicability in clinical practice as novel diagnostic, prognostic, and therapeutic tools. Finally, given the growing evidence supporting the immune system response, the oxidative stress-regulated mechanisms, and the gut microbiota composition as relevant emerging elements mutually influencing liver-cancerogenesis processes, we investigate the relationship of ncRNAs with this triad, shedding light on novel pathogenetic frontiers of HCC progression.

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Little things with significant impact: miRNAs in hepatocellular carcinoma

Cited by 8 publications

References 145 publications

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges

Role of Non-Coding RNAs in Hepatocellular Carcinoma Progression: From Classic to Novel Clinicopathogenetic Implications

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