Live birth after in vitro fertilization and single embryo transfer in a kidney transplant patient: a case report and review of the literature

Abstract

Background To present a successful case of in vitro fertilization (IVF) and single embryo transfer (SET) in a kidney transplant (NTX) patient and review of the literature. Methods Case report and review of the literature. Setting IVF-Unit in a university medical center. Patient(s) A 31 year-old nulliparous woman with primary infertility and a history of two kidney transplants. Intervention(s) IVF-SET Main outcome measure(s) Live birth, renal transplant function. Results(s) IVF-SET resulted in a pregnancy with labor induction and cesarean delivery in the 37th week of gestation due to rising serum creatinine. There was no significant maternal or fetal morbidity.Conclusion(s) Successful IVF-SET is possible in NTX patients. To date, including this case, five cases of IVF in NTX patients have been reported in the literature without an apparently increased renal morbidity.

Pregnancy Outcomes for Kidney Transplant Recipients

“…The following patient parameters were recorded: age, weight, height, cause of ESKD, time since transplantation, ethnicity, source of transplanted kidney, smoking status and prepregnancy immunosuppression and creatinine. Immunosuppression details are not specifically recorded prior to, or following, pregnancy but are routinely collected at months 1, 2, 3 and 6 and at years 1,2,3,5,7,10,15,20,25,30 and 35 after transplantation. Reporting of in vitro fertilization (IVF) is optional.…”

An Overview on Fertility Outcome in Renal Transplant Recipients

“…There are reports on infertile renal transplant recipients who had undergone successful in vitro fertilization treatments [13][14][15]. Pregnancy in renal transplant recipient is a high-risk pregnancy, which can get more complicated with in vitro fertilization treatment due to the risk of multiple births [16].…”

Procriação Assistida em Mulheres Transplantadas: Experiência de uma Unidade de Medicina da Reprodução e Revisão da Literatura

“…Tabela 1 -Utilização com sucesso de técnicas de PMA em mulheres transplantadas (casos publicados) [3][4][5][6][7][8][9][10][11][12] 2. Doente do sexo feminino de 33 anos, com infertilidade primária (por factor masculino), polineuropatia amiloidótica familiar (PAF), transplantada hepática há três anos (com boa função do enxerto), em imunossupressão com tacrolimus 5 mg/dia.…”

“…Existem 18 casos publicados de utilização, com sucesso, de técnicas de procriação medicamente assistida (PMA) em mulheres transplantadas: 15 renais, duas hepá-ticas e uma reno-pancreática (Tabela 1). [3][4][5][6][7][8][9][10][11][12] CASOS CLÍNICOS (Tabela 2)…”