Liver Abscess Caused by Multidrug-resistant &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; Treated with Colistin; A Case Report and Review of the Literature

Yaita, Kenichiro; Sameshima, Ichiro; Takeyama, Haruko; Matsuyama, Shinpei; Nagahara, Chie; Hashiguchi, Ryo; Moronaga, Yukiko; Tottori, Nami; Komatsu, Masanari; Oshiro, Yusuke; Yamaguchi, Yoshiaki

doi:10.2169/internalmedicine.52.9296

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…In addition, diverse series have described the recent appearance of rarer multi-resistant germs such as K. pneumoniae or E. coli producers of beta-lactamases or multi-drug resistant Pseudomonas aeruginosa [10]. …”

Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological characteristics of pyogenic liver abscess in people 65 years or older versus people under 65: a retrospective study

et al. 2017

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BackgroundTo analyse the clinical, epidemiological, microbiological and prognostic differences of pyogenic liver abscess (PLA) in older (≥ 65 years of age) versus younger patients (< 65 years).MethodsMulticentre, retrospective cohort study in all patients with PLA admitted to two Spanish hospitals from January 2000 to January 2014. Cases were divided into two age groups (< 65 years and ≥65 years) for comparison of clinical, epidemiological and microbiological characteristics as well as treatment.ResultsOf 98 patients analysed, 40 patients were younger than 65, and 58 were aged 65 or older. Significant associations in the older group were found with female sex (adjusted odds ratio [ORa] 9.0; 95% CI 1.4, 56), non-cryptogenic origin (ORa 14.5; 95% CI 1.6, 129), absence of chronic liver disease (ORa 14; 95% CI 1.3, 155), Escherichia coli infection (ORa 7.7; 95% CI 1.03, 58), and incidence of complications (ORa 2.3; 95% CI 1.04, 5.4). Mortality was 8.2% overall, although all deaths occurred in the older group (8/58; 13.8%) (p = 0.02).DiscussionOur results are in consonance with other published studies. Older patients with PLA tend to present more anomalies in the biliary tract (Kai et. al, World J Gastroenterol 18: 2948-295, 2012, Rahimian et. al, Clin Infect Dis 39:1654-9, 2004, Seeto, Medicine (Baltimore) 75:99-113, 1996, Kao et.al, Aliment Pharmacol Ther 36:467-76, 2012, Lai et. al, Gastroenterology 146:129-37, 2014), while younger patients are more often male and present more commonly with previous liver disease (especially related to alcohol) and cryptogenic PLA.ConclusionIn patients aged 65 or older, PLA was more common in women and in those with a history of biliary disease, and E. coli was the most frequent bacterium. Mortality was also higher in the older group.

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Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological characteristics of pyogenic liver abscess in people 65 years or older versus people under 65: a retrospective study

et al. 2017

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“…Streptococcus milleri, Escherichia coli, Streptococcus fecalis, Klebsiella pneumoniae and Proteus vulgaris infections arising through the biliary tract are the most common cause of liver abscesses. Clinical conditions such as complicated diverticular disease, appendicitis, peritonitis and pancreatitis may cause portal vein pyaemia leading to pyogenic liver abscesses [8,9] . Symptoms include pyrexia, right upper quadrant pain, malaise and anorexia, and in some cases tender hepatomegaly.…”

Section: Pyogenic Liver Abscessmentioning

confidence: 99%

“…Serum biochemistry shows elevation in bilirubin, alkaline phosphatase and transaminases. The available chemotherapy includes appropriate analgesics, antibiotic therapy and drainage of the abscess [8,9] .…”

Section: Pyogenic Liver Abscessmentioning

confidence: 99%

Bacterial Infection of Liver: A Bird’s Eye View

Parvez

Niyazi

2016

Journal of Gastroenterology and Hepatology Research

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The gastrointestinal tract is colonized by trillions of bacteria and, any injury of the gut barrier causes their translocation to liver and pathogenesis, directly or indirectly. The bacterial infections manifest as liver abscess, acute hepatitis, granulomatous hepatitis, hepatic tuberculosis, spontaneous peritonitis, spontaneous empyema, syphilitic hepatitis, and hepatic brucellosis. The diagnosis includes standard assays for stool and blood culture, biochemistry of liver function and radiology. Chemotherapy with antibiotics as per international guidelines is the treatment option.

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“…7 S. aureus, P. aeruginosa, and K. pneumoniae have been implicated in liver abscess. 8 P. aeruginosa is one of the most common causes of bacteraemia in liver transplant recipients. K. pneumoniae of high virulence (hvKP) has also been reported to lead to liver abscess in apparently healthy young adults.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization and antibiotic sensitivity testing of bacteria in blood cultures of Hepatitis B virus infected subjects

Anibijuwon

Ayanwale

Ayanda

2019

Sri Lankan J Infec Dis

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Introduction: Hepatitis B virus is one of the most common infections worldwide. Many infected people are at risk of developing liver complications. Screening for common pathogenic bacterial infections that could contribute to complications is important for early diagnosis and appropriate management. Methods: A cross sectional study was carried out on subjects aged 20-75 years for a period of 6 months (November 2016 to April 2017). Blood cultures and HBsAg rapid tests were performed on all 122 blood samples collected in Ilorin Metropolis. The screening was carried out on 92 HbsAg positive patients who presented with fever, and 30 apparently healthy HbsAg positive donors from the blood bank. Results: Of 92 symptomatic patients, 44 (47.8%) had postive blood cultures and of the 30 HBV positive blood donors, 9 (30%) had positive blood cultures. The prevalence of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae in Hepatitis B positive subjects was 5.7% (n=7), 5.7% (n=7), 23.8% (n=29) and 9.8% (n=12) respectively. In the apparently healthy HbsAg positive blood donor group, only 9 samples showed positive bacterial growth of P. aeruginosa. All the bacterial isolates were resistant to amoxycillin-clavulanic acid, erythromycin, ceftriaxone, ceftazidime, cefuroxime, and ciprofloxacin. On PCR, Nuc, Stx2, Pf and PSUE genes were demostrated in E. coli, S. aureus, P. aeruginosa and K. pneumoniae respectively. Conclusion: This study showed a high percentage (45.1%) of bacteraemia in HBV infection. Early screening and treatment of HBV infection and concomitant bacterial infection is recommended to prevent complications.

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Liver Abscess Caused by Multidrug-resistant <i>Pseudomonas aeruginosa</i> Treated with Colistin; A Case Report and Review of the Literature

Cited by 11 publications

References 22 publications

Clinical and epidemiological characteristics of pyogenic liver abscess in people 65 years or older versus people under 65: a retrospective study

Clinical and epidemiological characteristics of pyogenic liver abscess in people 65 years or older versus people under 65: a retrospective study

Bacterial Infection of Liver: A Bird’s Eye View

Molecular characterization and antibiotic sensitivity testing of bacteria in blood cultures of Hepatitis B virus infected subjects

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