2020
DOI: 10.3390/diagnostics10100784
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Liver Biopsy Hydroxyproline Content Is a Diagnostic for Hepatocellular Carcinoma in Murine Models of Nonalcoholic Steatohepatitis

Abstract: There is increasing evidence that nonalcoholic steatohepatitis (NASH) is a risk factor for hepatocellular carcinoma (HCC) in the absence of cirrhosis, a phenomenon termed noncirrhotic HCC. Early diagnosis of HCC is critical to a favorable prognosis. We tested the hypothesis that hydroxyproline content of liver biopsy samples is diagnostic for HCC in murine models of NASH induced by diet or by diet and chemicals. The training set comprised mice fed a standard diet or a fast-food diet with or without administrat… Show more

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Cited by 8 publications
(18 citation statements)
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“…In the present study, we tested the hypothesis that NASH with fibrosis is associated with upregulation of hepatic COL I and COL III, both of which are fibrillar collagens. Consistent with previous reports [ 4 , 5 , 6 ], livers from mice randomized to a FFD exhibited hallmark features of NASH with fibrosis, i.e., lipid deposition, inflammation, hepatocyte ballooning, increased serum AST and ALT, and matrix deposition. The novel finding in this study was increased hepatic col1a1, col1a2, and col3a1 accompanying NASH with fibrosis.…”
Section: Discussionsupporting
confidence: 91%
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“…In the present study, we tested the hypothesis that NASH with fibrosis is associated with upregulation of hepatic COL I and COL III, both of which are fibrillar collagens. Consistent with previous reports [ 4 , 5 , 6 ], livers from mice randomized to a FFD exhibited hallmark features of NASH with fibrosis, i.e., lipid deposition, inflammation, hepatocyte ballooning, increased serum AST and ALT, and matrix deposition. The novel finding in this study was increased hepatic col1a1, col1a2, and col3a1 accompanying NASH with fibrosis.…”
Section: Discussionsupporting
confidence: 91%
“…However, the risk associated with NAFLD is not merely limited to the need for transplantation but also includes the risk of developing HCC. In fact, a preponderance of experimental and clinical evidence suggests that increased scar deposition in the liver is associated with transformation of the liver to a cancerous phenotype [ 4 , 5 , 6 , 12 , 13 , 14 , 15 , 16 ]. In murine models of NASH, livers with the highest hydroxyproline content, a component of collagen, exhibited evidence of HCC [ 4 , 6 ].…”
Section: Discussionmentioning
confidence: 99%
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