Liver disease in ulcerative colitis: an epidemiological and follow up study in the county of Stockholm.

Abstract

In an epidemiological study of the incidence of ulcerative colitis (UC) in the county of Stockholm between 1955Stockholm between and 1979Stockholm between , 1274 (p<O-OOOl). The number of patients with UC who developed PSC remained constant during the study period. Thus, although evidence of abnormal liver function is a common finding in UC, a spontaneous return to normal levels is common. In this study, which did not have a selection bias, the median time of survival among PSC patients was far longer than previously described although development of PSC among patients with UC does significantly reduce the estimated median time of survival.

Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease

“…In the late 1990s, patients with IBD were considered to be at risk of HCV and HBV infection, probably due to previous surgery or blood transfusions. [1][2][3][4][5] Prevalence of HBV infection Some relatively 'old' studies have reported a significantly higher prevalence of HBV infection in IBD patients than in controls. For example, Biancone et al 2 reported that 11% of IBD patients had antibodies to hepatitis B core protein (anti-HBc), a statistically significantly higher figure than in controls.…”

Primary sclerosing cholangitis

“…The median reported survival in patients with PSC is 10 to 12 years from the time of diagnosis, 42,74,75 although an active search for PSC in screening programs may lead to the identification of patients in an early stage of disease who can expect a significantly longer survival. 47,76 The disease, however, generally follows a progressive course, and most asymptomatic patients eventually develop symptoms of chronic cholestasis and biliary cirrhosis with its consequent complications. 2 Several variables such as older age; serum levels of bilirubin, albumin, and aspartate aminotransferase; hepatosplenomegaly; variceal bleeding; presence of IBD; and histological stage have been identified as independent risk factors for predicting a poor prognosis.…”

Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença

“…A incidência de manifestações hepáticas em pacientes com DII varia de 5-95% (7,29,35,46,47,48,49). Em nossa casuística encontramos uma incidência de 14,9%, sendo 13,2% para RCU e 16,9% para DC.…”

“…Bargiggia et al(2003) evidenciaram anormalidades ultra-sonográficas em 55,1% dos pacientes com DII investigados sistematicamente(DC-54,3% e RCU-55,9%) (48).…”